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A hemA mutation renders Salmonella typhimurium avirulent in mice, yet capable of eliciting protection against intravenous infection with S. typhimurium.

Abstract：

:The hemA mutation reduces the virulence of Salmonella typhimurium for mice by at least 10(7)-fold, as measured by change in LD50. The hemA mutation does not appear to affect killing of salmonella in mice. The salmonella with the hemA mutation persist in the spleen and liver for 2 to 3 weeks following intravenous injection. The most likely effect of the hemA mutation is to block, or retard, growth of S. typhimurium in an aerobic in vivo environment. Intravenous vaccination of susceptible ltys mice with hemA salmonella was able to elicit about 4 logs of protection against invasive infection with wild-type S. typhimurium 78 days after vaccination, at a time when the vaccine strain was no longer detectable in the spleen and liver.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Benjamin WH Jr,Hall P,Briles DE

doi

10.1016/0882-4010(91)90033-7

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

289-95

issue

4

eissn

0882-4010

issn

1096-1208

pii

0882-4010(91)90033-7

journal_volume

11

pub_type

杂志文章

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