Identification and characterization of the ribosome-associated protein, HrpA, of Bacillus Calmette-Guérin.

Abstract:

:HrpA was found as a ribosome-associated protein which appeared in heat-stressed Mycobacterium bovis Bacillus Calmette-Guérin. Here, we have studied the function of HrpA in vitro. HrpA is a heat shock protein belonging to a small heat shock protein family. The putative molecular mass was 17784.86 kDa. Recombinant HrpA formed large complexes of nonamer or dodecamer. HrpA prevented the aggregation of enzymes under heat shock conditions, and it formed stable complexes with partially denatured enzymes. HrpA was induced temporarily by oxygen repletion after anaerobic condition.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Tabira Y,Ohara N,Yamada T

doi

10.1006/mpat.2000.0384

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

213-22

issue

4

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(00)90384-X

journal_volume

29

pub_type

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