Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease.


:Recent studies have been considered to symbiotic interactions of the human gastrointestinal microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota continuously stimulates the immune system against opportunistic and pathogen bacteria from infancy. Changes in gastrointestinal microbiota have been associated with numbers of human diseases such as allergic diseases, autoimmune encephalitis, atherosclerosis, colorectal cancer, obesity, diabetes etc. In this review article, we evaluate studies on the roles of human gastrointestinal microbiota and interference pathogenicity in allergic diseases, obesity, and diabetes. Several studies indicated association between allergic diseases and changes in bacterial balance such as increased of Clostridium spp., some species of Bifidobacterium spp., or decreased of Bacteroidetes phylum and some species of Bifiobacterium spp. and production of specific short-chain fatty acids due to food type, delivery modes of infant, infant evolvement environment and time of getting bacteria at an early-life age. In addition, obesity and diabetes are associated with food type, production of short chain fatty acids undergo fermentation of the intestinal microbiota, metabolic endotoxemia, endocannabinoid system and properties of the immune system. Well-characterized underlying mechanisms may provide novel strategies for using prebiotic and probiotic to prevent and treatment of allergic diseases, obesity, diabetes, and other lifestyle-related disorders.


Microb Pathog


Microbial pathogenesis


Gholizadeh P,Mahallei M,Pormohammad A,Varshochi M,Ganbarov K,Zeinalzadeh E,Yousefi B,Bastami M,Tanomand A,Mahmood SS,Yousefi M,Asgharzadeh M,Kafil HS




Has Abstract


2019-02-01 00:00:00












  • Worldwide prevalence of emerging parasite Blastocystis in immunocompromised patients: A systematic review and meta-analysis.

    abstract:BACKGROUND:Blastocystis is one of the most common pathogens of the human intestine, caused by an emerging parasite, which can lead to severe symptoms and even death in immunocompromised patients. We aimed to determine the global prevalence of Blastocystosis infection in people with immunodeficiency. A systematic litera...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Khorshidvand Z,Khazaei S,Amiri M,Taherkhani H,Mirzaei A

    更新日期:2020-11-24 00:00:00

  • Rational selection of broadly cross-reactive family 2 PspA molecules for inclusion in chimeric pneumococcal vaccines.

    abstract::Pneumococcal surface protein A (PspA) is a widely studied pneumococcal protein, exposed at the surface of all strains. It is an important virulence factor, preventing complement deposition as well as inhibiting the lytic effects of lactoferrin over pneumococci. Several studies have investigated the use of PspA as a ca...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Converso TR,Goulart C,Rodriguez D,Darrieux M,Leite LCC

    更新日期:2017-08-01 00:00:00

  • Cloning and molecular analysis of genes encoding two immunodominant antigens of Ehrlichia risticii.

    abstract::Ehrlichia risticii, the causative agent of Potomac horse fever, is an obligate intracellular rickettsial organism. To understand the role of 55 and 51 kilodalton immunodominant antigens of E. risticii in strain variation, their genes from the 25-D and 90-12 strains were cloned, sequenced, and expressed in E. coli. Seq...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Vemulapalli R,Biswas B,Dutta SK

    更新日期:1998-06-01 00:00:00

  • Yeasts isolated from Brazilian fermented foods in the protection against infection by pathogenic food bacteria.

    abstract::The consumption of probiotics has increased due to the reported health benefits, mainly in preventing or treating gastrointestinal pathology. This study investigated the antimicrobial capacity of yeasts, Saccharomyces cerevisiae and Pichia kluyveri, previously isolated from fermented foods (indigenous beverage, kefir ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Menezes AGT,Melo DS,Ramos CL,Moreira SI,Alves E,Schwan RF

    更新日期:2020-03-01 00:00:00

  • Recombinant C-terminal 311 amino acids of HapS adhesin as a vaccine candidate for nontypeable Haemophilus influenzae: A study on immunoreactivity in Balb/C mouse.

    abstract::Hap, an auto-transporter protein, is an antigenically conserved adhesion protein which is present on both typeable and nontypeable Haemophilus influenzae. This protein has central role in bacterial attachment to respiratory tract epithelial cells. A 1000bp C-terminal fragment of Hap passenger domain (HapS) from nontyp...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Tabatabaee Bafroee AS,Siadat SD,Mousavi SF,Aghasadeghi MR,Khorsand H,Nejati M,Sadat SM,Mahdavi M

    更新日期:2016-09-01 00:00:00

  • Species and strain specificity of Lactobacillus probiotics effect on weight regulation.

    abstract::Certain strains of Lactobacillus appear to have a reproducible effect on weight as a weight-gain effect in lean humans and animals or a weight-loss effect in overweight/obese humans and animals. These results are completely sufficient to capture the attention of the scientific community to assess the effect on the wei...

    journal_title:Microbial pathogenesis

    pub_type: 评论,信件


    authors: Million M,Raoult D

    更新日期:2013-02-01 00:00:00

  • Protective effect of SKB_Gutbiotic against castor oil and E.coli induced diarrhea in laboratory animals.

    abstract::The aim of this study is to evaluate antidiarrheal activity of SKB_Gutbiotic against Castor oil and E.coli induced diarrhea in Swiss albino mice and Sprague Dawley rats. In present study three doses of SKB_Gutbiotic were tested against castor oil induced diarrhea in mice. Its effect on co-administration with l-arginin...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Vanjari H,Mohan M,Saudagar P,Guthale G,Dalvi M

    更新日期:2020-06-01 00:00:00

  • Gut microbiome-based medical methodologies for early-stage disease prevention.

    abstract::Recent advancements highlight the important role of gut microbiome in human health. However, a variety of endogenous and exogenous factors, such as genes, foods, drugs, environmental pollutions, oxidative stress, etc., may interfere with the gut microbiome in vivo and increase risks of digestive system diseases, cardi...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章,评审


    authors: Wang JZ,Du WT,Xu YL,Cheng SZ,Liu ZJ

    更新日期:2017-04-01 00:00:00

  • Zinc-dependent cytoadherence of Legionella pneumophila to human alveolar epithelial cells in vitro.

    abstract::Microbial adherence to host cells is an early key step in the establishment of infection. During the course of Legionnaire's disease, Legionella interactions with host cells are best documented for resident macrophages. However, L. pneumophila can also replicate within type I and type II pneumocytes, which cover almos...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Yaradou DF,Raze D,Ginevra C,Ader F,Doléans-Jordheim A,Vandenesch F,Menozzi FD,Etienne J,Jarraud S

    更新日期:2007-11-01 00:00:00

  • Evaluation of antibacterial and modifying action of catechin antibiotics in resistant strains.

    abstract::Diseases caused by bacteria are today one of the great problems of present time. Access to over-the-counter medication, the indiscriminate use of antibacterials and high rates of hospitalization have contributed to the increase in cases. This picture has led to the search for new alternative drugs. Thus, secondary met...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Gomes FMS,da Cunha Xavier J,Dos Santos JFS,de Matos YMLS,Tintino SR,de Freitas TS,Coutinho HDM

    更新日期:2018-02-01 00:00:00

  • The role of Listeria monocytogenes cell wall surface anchor protein LapB in virulence, adherence, and intracellular replication.

    abstract::Lmof2365_2117 is a Listeria monocytogenes putative cell wall surface anchor protein with a conserved domain found in collagen binding proteins. We constructed a deletion mutation in lmof2365_2117 in serotype 4b strain F2365, evaluated its virulence, and determined its ability to adhere and invade colonic epithelial ce...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Reddy S,Akgul A,Karsi A,Abdelhamed H,Wills RW,Lawrence ML

    更新日期:2016-03-01 00:00:00

  • Expression of the Escherichia coli IrgA homolog adhesin is regulated by the ferric uptake regulation protein.

    abstract::The IrgA homolog adhesin (Iha) is an adherence-conferring outer membrane protein of Escherichia coli associated with enterohemorrhagic and uropathogenic strains. Here, we used primer extension analysis to identify iha promoters in O157:H7 and uropathogenic E. coli strains. Transcriptional fusions demonstrated that iha...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Rashid RA,Tarr PI,Moseley SL

    更新日期:2006-12-01 00:00:00

  • Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.

    abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) is acknowledged a fulminating infectious pathogen affecting the pig farming industry, and current vaccines and drugs could hardly inhibit this virus. The 2', 5'-oligoadenylate synthetase (OASs) have antiviral activities, but the role(s) played by porcine OAS2...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Zhao M,Wan B,Li H,He J,Chen X,Wang L,Wang Y,Xie S,Qiao S,Zhang G

    更新日期:2017-10-01 00:00:00

  • Adhesion, invasion and intracellular replication of Salmonella typhimurium in a murine hepatocyte cell line. Effect of cytokines and LPS on antibacterial activity of hepatocytes.

    abstract::Elimination of pathogenic microorganisms in the liver may be an important effector mechanism in host defenses. In this paper we describe the adhesion, invasion and multiplication of Salmonella typhimurium in a murine embryonic hepatocyte cell line (ATCC TIB-73). Monolayers of hepatocytes treated with recombinant IFN g...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Lajarin F,Rubio G,Galvez J,Garcia-Peñarrubia P

    更新日期:1996-11-01 00:00:00

  • Susceptibility of mouse mammary glands to murine gammaherpesvirus 72 (MHV-72) infection: evidence of MHV-72 transmission via breast milk.

    abstract::Murine gammaherpesvirus 72 (MHV-72) is a virus of wild rodents and serves as a convenient small animal model to understand the pathogenesis of Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV8) infection. In laboratory mice MHV-72 causes an acute infection of lung epithelial cells and establishes the latency in B...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Raslova H,Berebbi M,Rajcani J,Sarasin A,Matis J,Kudelova M

    更新日期:2001-08-01 00:00:00

  • Ultrastructure and phylogenetic characterization of the microsporidian parasite Heterosporis lessepsianus n. sp. (Microsporidia: Glugeidae) infecting the lizardfish Saurida lessepsianus (Pisces: Synodontidae) inhabiting the Red Sea.

    abstract::Heterosporosis is an increasingly important microsporidian disease distributed worldwide, impacting wild and farmed-raised fish in both fresh and marine water environments. Twenty three out of 130 (17.69%) of the lizardfish Saurida lessepsianus were found to be naturally infected with microsporidian parasites. The rat...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Al Quraishy S,Abdel-Gaber R,El Deeb N,Maher S,Al-Shaebi E,Abdel-Ghaffar F

    更新日期:2019-05-01 00:00:00

  • Deletion and overexpression studies on DacB2, a putative low molecular mass penicillin binding protein from Mycobacterium tuberculosis H(37)Rv.

    abstract::Mycobacterium tuberculosis genome encodes several high and low molecular mass penicillin binding proteins. One such low molecular mass protein is DacB2 encoded by open reading frame Rv2911 of M. tuberculosis which is predicted to play a role in peptidoglycan synthesis. In this study we have tried to gain an insight in...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Bourai N,Jacobs WR Jr,Narayanan S

    更新日期:2012-02-01 00:00:00

  • Chlamydia pneumoniae facilitates monocyte adhesion to endothelial and smooth muscle cells.

    abstract::Chlamydia pneumoniae has been linked to atherosclerotic heart disease. However, there is a limited knowledge by which C. pneumoniae gain access to atheromatous lesions. The adhesion of C. pneumoniae -infected circulatory component(s) to endothelium and smooth muscle cells represents the first step in an inflammatory r...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Kaul R,Wenman WM

    更新日期:2001-03-01 00:00:00

  • Balamuthia amoebic encephalitis: an emerging disease with fatal consequences.

    abstract::Balamuthia amoebic encephalitis (BAE), caused by the protozoan pathogen, Balamuthia mandrillaris, is a serious human disease with fatal consequences and a mortality rate of more than 95%. A key factor that contributes to the high mortality is the incomplete understanding of its pathogenesis and pathophysiology. The mo...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章,评审


    authors: Siddiqui R,Khan NA

    更新日期:2008-02-01 00:00:00

  • GroEL PCR- RFLP - An efficient tool to discriminate closely related pathogenic Vibrio species.

    abstract::Vibrio sp. are autochthonous to marine and estuarine waters. Several species of Vibrio are pathogens. It is of utmost importance to detect and discriminate the Vibrio sp. that are often involved in food and water borne infections. Since 16S rRNA based identification has limited utility in differentiating the closely r...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Silvester R,Alexander D,Antony AC,Hatha M

    更新日期:2017-04-01 00:00:00

  • Genome-wide identification of genes regulated by RcsA, RcsB, and RcsAB phosphorelay regulators in Klebsiella pneumoniae NTUH-K2044.

    abstract::Rcs phosphorelay system is a two-component signal transduction system, which can regulate the transcription of capsule polysaccharide and biofilm related genes in Enterobacteriaceae. In this study, microarray technology was used to investigate the overall genes regulated by RcsA, RcsB, and RcsAB and the regulation mec...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Su K,Zhou X,Luo M,Xu X,Liu P,Li X,Xue J,Chen S,Xu W,Li Y,Qiu J

    更新日期:2018-10-01 00:00:00

  • Molecular epidemiology of porcine reproductive and respiratory syndrome virus in Central China since 2014: The prevalence of NADC30-like PRRSVs.

    abstract::Porcine reproductive and respiratory syndrome (PRRS), characterized by respiratory disorders in piglets and reproductive failure in sows, is still the great threat of swine industry. Recently, Emergence of the novel NADC30-like PRRS viruses (PRRSVs) has caused widespread outbreaks of PRRS. To investigate the epidemic ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Wang LJ,Xie W,Chen XX,Qiao S,Zhao M,Gu Y,Zhao BL,Zhang G

    更新日期:2017-08-01 00:00:00

  • Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models.

    abstract::Type VI secretion systems (T6SSs) have been identified recently in several Gram-negative organisms and have been shown to be associated with virulence in some bacterial pathogens. A T6SS of Yersinia pestis CO92 (locus YPO0499-YPO0516) was deleted followed by investigation of the phenotype of this mutation. We observed...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Robinson JB,Telepnev MV,Zudina IV,Bouyer D,Montenieri JA,Bearden SW,Gage KL,Agar SL,Foltz SM,Chauhan S,Chopra AK,Motin VL

    更新日期:2009-11-01 00:00:00

  • Development of inflammation and augmented chemotactic responsiveness of murine peritoneal macrophages following treatment with Entamoeba histolytica trophozoites.

    abstract::The accumulation of inflammatory cells in the peritoneal cavity of C57BL/6 mice was examined following intraperitoneal injection of Entamoeba histolytica trophozoites. Two different strains of E. histolytica were used: a virulent strain (IP:0682:1) and a non-virulent strain (DKB). Injection of 10(6) trophozoites of ei...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Ghadirian E,Stevenson MM

    更新日期:1987-09-01 00:00:00

  • Characterization of LIC11207, a novel leptospiral protein that is recognized by human convalescent sera and prevents apoptosis of polymorphonuclear leukocytes.

    abstract::We report the study of a predicted outer-membrane leptospiral protein encoded by the gene lic11207. This protein is conserved in several pathogenic leptospiral strains but is absent in the saprophyte Leptospira biflexa. This putative outer-membrane protein has a domain of unknown function (DUF) 1565 found in several p...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Pretre G,Lapponi MJ,Atzingen MV,Schattner M,Nascimento AL,Gómez RM

    更新日期:2013-03-01 00:00:00

  • Interaction of heat-stable enterotoxins with human colonic (T84) cells: modulation of the activation of guanylyl cyclase.

    abstract::Heat-stable enterotoxins (ST) activate guanylyl cyclase in T84 cells, rapidly and specifically. Activation is monitored by cGMP production and occurs at lower concentrations of ST than required for eliciting fluid accumulation in suckling mice. Atrial natriuretic factor (ANF) neither activates guanylyl cyclase nor mod...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Visweswariah SS,Shanthi G,Balganesh TS

    更新日期:1992-03-01 00:00:00

  • The chicken as a natural model for extraintestinal infections caused by avian pathogenic Escherichia coli (APEC).

    abstract::E. coli infections in avian species have become an economic threat to the poultry industry worldwide. Several factors have been associated with the virulence of E. coli in avian hosts, but no specific virulence gene has been identified as being entirely responsible for the pathogenicity of avian pathogenic E. coli (AP...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Antão EM,Glodde S,Li G,Sharifi R,Homeier T,Laturnus C,Diehl I,Bethe A,Philipp HC,Preisinger R,Wieler LH,Ewers C

    更新日期:2008-11-01 00:00:00

  • Microbial radiosensitization using combined treatments of essential oils and irradiation- part B: Comparison between gamma-ray and X-ray at different dose rates.

    abstract::Stored rice and rice products are prone to contamination by pathogenic fungi and bacteria such as Aspergillus niger, Bacillus cereus, and Paenibacillus amylolyticus. Treatment with antimicrobial essential oils (EOs) and irradiation are options to control spoilage organisms. Microbial samples with or without fumigation...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Shankar S,Follett P,Ayari S,Hossain F,Salmieri S,Lacroix M

    更新日期:2020-06-01 00:00:00

  • Effects of Pasteurella multocida lipopolysaccharides on bovine leukocytes.

    abstract::Lipopolysaccharide (LPS) is a major virulence factor of Gram-negative bacteria playing a major role in stimulating protective immune response in mammalian host. However, in many gram-negative bacterial infections, LPS also elicits immunopathology by inducing excessive inflammatory changes. P. multocida (Pm), a gram-ne...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Periasamy S,Praveena PE,Singh N

    更新日期:2018-06-01 00:00:00

  • Potential of Bacillus amyloliquefaciens for biocontrol of bacterial canker of tomato incited by Clavibacter michiganensis ssp. michiganensis.

    abstract::A total of 150 rhizobacteria and endorhizobacteria previously isolated from three different horticultural crops; strawberry, apple and apricot were screened for antagonistic activitiy against Clavibacter michiganensis ssp. michiganensis. Among them strain S1, exhibiting significantly higher antagonistic and plant grow...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Gautam S,Chauhan A,Sharma R,Sehgal R,Shirkot CK

    更新日期:2019-05-01 00:00:00