Abstract：
:Streptococcus pneumoniae attach to human pharyngeal epithelial cells through the specific interaction of bacterial surface adhesins with glycoconjugate receptors. The present study defines the adhesin as a molecule bridging between an anchoring site in the bacterial cell wall and the epithelial cell receptor. The nature of the adhesin was defined in three ways: First, the attachment of whole bacteria was reduced by trypsin, periodate and heat. Second, heat treatment of whole bacteria was shown to release material, which was able to reconstitute the adherence. The heat extract bound to epithelial cells, as shown by fluorescence labelling, and agglutinated latex beads covalently coupled with receptor oligosaccharide. Active material could be extracted by heat from both high and low adhering strains, but could reconstitute only attaching strains. Third, the bacterial component binding the adhesin was localized to protoplasts and cell wall fractions obtained by mechanical or deoxycholate induced lysis of pneumococci. Isolated pneumococcal surface components, which did not inhibit attachment, included peptidoglycan, C polysaccharide, Forssmann antigen, capsular polysaccharide and a phenol extract produced in analogy to streptococcal lipoteichoic acid. The procedure used to extract the adhesin was previously used to prepare the competence factor. The competence deficient mutant RA7- attached poorly compared to the competent R6 parent. The possible relatedness of attachment to competence is discussed.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Andersson B,Beachey EH,Tomasz A,Tuomanen E,Svanborg-Edén Cdoi
10.1016/0882-4010(88)90087-3subject
Has Abstractpub_date
1988-04-01 00:00:00pages
267-78issue
4eissn
0882-4010issn
1096-1208journal_volume
4pub_type
杂志文章abstract：:Staphylococcus aureus (S. aureus) is one of several opportunistic microbial pathogens associated with many healthcare problems. In the present study, S. aureus was assessed for its biofilm-forming ability on materials routinely used in dental offices, including stainless steel (SS), polyethylene (PE), and polyvinyl ch...
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
pub_type： 杂志文章,评审
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更新日期：1994-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
doi：10.1016/j.micpath.2012.09.008
更新日期：2013-02-01 00:00:00
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journal_title：Microbial pathogenesis
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更新日期：2000-04-01 00:00:00
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journal_title：Microbial pathogenesis
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doi：10.1016/j.micpath.2017.09.034
更新日期：2017-10-01 00:00:00
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更新日期：2019-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Microbial pathogenesis
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更新日期：2007-08-01 00:00:00
abstract：:Salmonella spp. have been investigated as live vaccine vectors because they are heat stable and can elicit humoral, cellular, and secretory immune responses. However, the expression of some foreign antigens is toxic to bacterial vectors. We therefore studied an approach for the controlled expression of antigen in Salm...
journal_title：Microbial pathogenesis
pub_type： 杂志文章
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更新日期：1993-08-01 00:00:00
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更新日期：2017-03-01 00:00:00
