Modulation of the antibiotic activity against multidrug resistant strains of coumarins isolated from Rutaceae species.

Abstract:

:The first occurrences and dissemination of resistant microorganisms led to the inefficacy of many antibiotics, available in the market nowadays, therefore, the search for new substances with antimicrobial activity from natural sources has gained a great importance. The purpose of this work is to evaluate the antibacterial activity and modulation of drug resistance in Staphylococcus aureus by coumarins such as bergapten, xantotoxin, isopimpinellin and imperatorin obtained from two Rutaceae species (Metrodorea mollis and Pilocarpus spicatus). The antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC), using the microdilution method. The MIC was >256 g/mL for all coumarins tested. Regarding the modulation of drug resistance assay, the isopimpinellin reducted the MIC of erytromicin by 4 times, whereas imperatorin exhibited the best result, reducing the MIC of tetracycline (2 times), erytomicin (4 times) and norfloxacin (4 times). By reducing the MIC of ethidium bromide, the imperatorin is consider in fact, as a putative efflux pump inhibitor of bacteria.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Madeiro SA,Borges NH,Souto AL,de Figueiredo PT,Siqueira-Junior JP,Tavares JF

doi

10.1016/j.micpath.2017.01.028

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

151-154

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(16)30853-1

journal_volume

104

pub_type

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