Modulation of the antibiotic activity against multidrug resistant strains of coumarins isolated from Rutaceae species.


:The first occurrences and dissemination of resistant microorganisms led to the inefficacy of many antibiotics, available in the market nowadays, therefore, the search for new substances with antimicrobial activity from natural sources has gained a great importance. The purpose of this work is to evaluate the antibacterial activity and modulation of drug resistance in Staphylococcus aureus by coumarins such as bergapten, xantotoxin, isopimpinellin and imperatorin obtained from two Rutaceae species (Metrodorea mollis and Pilocarpus spicatus). The antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC), using the microdilution method. The MIC was >256 g/mL for all coumarins tested. Regarding the modulation of drug resistance assay, the isopimpinellin reducted the MIC of erytromicin by 4 times, whereas imperatorin exhibited the best result, reducing the MIC of tetracycline (2 times), erytomicin (4 times) and norfloxacin (4 times). By reducing the MIC of ethidium bromide, the imperatorin is consider in fact, as a putative efflux pump inhibitor of bacteria.


Microb Pathog


Microbial pathogenesis


Madeiro SA,Borges NH,Souto AL,de Figueiredo PT,Siqueira-Junior JP,Tavares JF




Has Abstract


2017-03-01 00:00:00












  • Stable isotope labelling by amino acids in cell culture (SILAC) applied to quantitative proteomics of Edwardsiella tarda ATCC 15947 under prolonged cold stress.

    abstract::Edwardsiella tarda poses a threat to human health and has resulted in enormous economic losses in aquaculture. Low temperatures are usually applied to contain the growth of this microorganism. In this study, stable isotope labelling by amino acids in cell culture (SILAC) was used to conduct comparative proteomic quant...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Ma W,Jia J,Huang X,Xie W,Zhang X,Tang J,Lin C,Zhao L,Fang P

    更新日期:2018-12-01 00:00:00

  • Comparative analysis of Bacterial Vaginosis microbiota among pregnant and non-pregnant females and isolation of phages against Enterococcus faecalis, Enterococcus faecium, and Shigella flexneri strains.

    abstract:BACKGROUND AND OBJECTIVES:Bacterial vaginosis (BV) is the most common vaginal infection in women of reproductive age. It shifts the paradigms of the vagina from healthy, beneficial microbiota to facultative and strict anaerobes. BV remains one of the most arduous and controversial challenges in modern-day clinical micr...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Javed A,Manzoor S

    更新日期:2020-12-01 00:00:00

  • Principle component analysis (PCA) for investigation of relationship between population dynamics of microbial pathogenesis, chemical and sensory characteristics in beef slices containing Tarragon essential oil.

    abstract::Principle component analysis (PCA) was employed to examine the effect of the exerted treatments on the beef shelf life as well as discovering the correlations between the studied responses. Considering the variability of the dimensions of the responses, correlation coefficients were applied to form the matrix and extr...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Alizadeh Behbahani B,Tabatabaei Yazdi F,Shahidi F,Mortazavi SA,Mohebbi M

    更新日期:2017-04-01 00:00:00

  • Influence of mycobacterial virulence and culture condition on gamma delta T cell activation.

    abstract::Activation of human gamma delta T cells by culture supernatants of virulent and avirulent mycobacteria was examined. The stimulatory potential of mycobacteria was influenced by the type of culture media and independent from their virulence. Activation of gamma delta T cells by phagocytes infected with viable virulent ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Schoel B,Kaufmann SH

    更新日期:1998-03-01 00:00:00

  • Cloning and molecular analysis of genes encoding two immunodominant antigens of Ehrlichia risticii.

    abstract::Ehrlichia risticii, the causative agent of Potomac horse fever, is an obligate intracellular rickettsial organism. To understand the role of 55 and 51 kilodalton immunodominant antigens of E. risticii in strain variation, their genes from the 25-D and 90-12 strains were cloned, sequenced, and expressed in E. coli. Seq...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Vemulapalli R,Biswas B,Dutta SK

    更新日期:1998-06-01 00:00:00

  • Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora.

    abstract::Escherichia coli O157:H7 is a food-borne pathogen that can cause hemorrhagic colitis and, occasionally, hemolytic uremic syndrome, a sequela of infection that can result in renal failure and death. Here we sought to model the pathogenesis of orally-administered E. coli O157:H7 in BALB/c mice with an intact intestinal ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Mohawk KL,Melton-Celsa AR,Zangari T,Carroll EE,O'Brien AD

    更新日期:2010-03-01 00:00:00

  • Complete genome sequence analysis of the fish pathogen Flavobacterium columnare provides insights into antibiotic resistance and pathogenicity related genes.

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    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Zhang Y,Zhao L,Chen W,Huang Y,Yang L,Sarathbabu V,Wu Z,Li J,Nie P,Lin L

    更新日期:2017-10-01 00:00:00

  • Susceptibility of mouse mammary glands to murine gammaherpesvirus 72 (MHV-72) infection: evidence of MHV-72 transmission via breast milk.

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    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Raslova H,Berebbi M,Rajcani J,Sarasin A,Matis J,Kudelova M

    更新日期:2001-08-01 00:00:00

  • Treatment with 3'-deoxyadenosine and deoxycoformycin in mice infected by Trypanosoma cruzi and its side effect on purinergic enzymes.

    abstract::The aim of this study was to evaluate the efficacy of 3'-deoxyadenosine and deoxycoformycin combination in the treatment of mice infected by T. cruzi, as well as to verify the influence of the treatment on purinergic enzymes. Heart and serum samples were collected from 60 mice (30 infected and 30 uninfected) at day 12...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: do Carmo GM,Doleski PH,de Sá MF,Grando TH,Azevedo MI,Manzoni AG,Leal DBR,Gressler LT,Henker LC,Mendes RE,Baldissera MD,Monteiro SG,Stefani LM,Da Silva AS

    更新日期:2017-12-01 00:00:00

  • myc-related proteins and DNA sequences in Trypanosoma brucei.

    abstract::The cAMP content of Trypanosoma brucei increases in parallel with ascending mammalian parasitemia to very high levels just before differentiation of the long-slender to the short-stumpy bloodstream form. Because expression of myc oncogenes is required for vertebrate cells to interpret proliferation signals and decline...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Davis CE,Colmerauer ME,Kim CH,Matthews B,Guiney DG

    更新日期:1989-07-01 00:00:00

  • Molecular-genetic peculiarities of classical biotype Vibrio cholerae, the etiological agent of the last outbreak Asiatic cholera in Russia.

    abstract::Molecular-genetic properties of classical biotype Vibrio cholerae strains that caused the Asiatic cholera outbreak in 1942 in Russia have been investigated for the first time. Being characterized by high-level production of cholera toxin and toxin-coregulated adhesion pili both of which are the major virulence factors...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Smirnova NI,Cheldyshova NB,Zadnova SP,Kutyrev VV

    更新日期:2004-03-01 00:00:00

  • Reactivity of Haemophilus influenzae type b anti-pili antibodies.

    abstract::The reactivity of anti-pilus antibodies to native and denatured Haemophilus influenzae b (Hib) pili was studied using rabbit serum prepared against piliated H. influenzae b strain M43 (p+) and adsorbed with its non-piliated variant, strain M42 (p-). The specificity of the adsorbed serum for Hib pili was documented by ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Gilsdorf JR,Forney LJ,LiPuma JJ

    更新日期:1989-10-01 00:00:00

  • Elucidation of genetic relatedness of Magnaporthe grisea, an incitent of pearl millet blast disease by molecular markers associated with virulence of host differential cultivars.

    abstract::In recent years, blast disease caused by Magnaporthe grisea, an ascomycete fungus is becoming a serious threat to pearl millet crop in India and worldwide. Due to the increase in virulent races of pathogen, blast disease management strategies seemed to be very limited. Hence, unraveling the occurrence of blast isolate...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Adhikari S,Joshi SM,Athoni BK,Patil PV,Jogaiah S

    更新日期:2020-12-01 00:00:00

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    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Brogden KA,Engen RL,Songer JG,Gallagher J

    更新日期:1990-02-01 00:00:00

  • Polymicrobial antibiofilm activity of the membranotropic peptide gH625 and its analogue.

    abstract::This work illustrates a new role for the membranotropic peptide gH625 and its derivative gH625-GCGKKK in impairing formation of polymicrobial biofilms. Mixed biofilms composed of Candida and bacterial species cause frequently infections and failure of medical silicone devices and also show a major drug resistance than...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: de Alteriis E,Lombardi L,Falanga A,Napolano M,Galdiero S,Siciliano A,Carotenuto R,Guida M,Galdiero E

    更新日期:2018-12-01 00:00:00

  • Opsonization of Staphylococcus aureus with a fibronectin-binding protein antiserum induces protection in mice.

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    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Mamo W,Jonsson P,Müller HP

    更新日期:1995-07-01 00:00:00

  • Microbial radiosensitization using combined treatments of essential oils and irradiation- part B: Comparison between gamma-ray and X-ray at different dose rates.

    abstract::Stored rice and rice products are prone to contamination by pathogenic fungi and bacteria such as Aspergillus niger, Bacillus cereus, and Paenibacillus amylolyticus. Treatment with antimicrobial essential oils (EOs) and irradiation are options to control spoilage organisms. Microbial samples with or without fumigation...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Shankar S,Follett P,Ayari S,Hossain F,Salmieri S,Lacroix M

    更新日期:2020-06-01 00:00:00

  • Stress tolerance of Staphylococcus aureus with different antibiotic resistance profiles.

    abstract::Staphylococcus aureus (S. aureus) is a zoonotic bacterium and is among the most important pathogens causing bacterial foodborne diseases. In recent years, disease caused by antibiotic-resistant S. aureus is a serious clinical problem that poses a great threat to public health. In this study, we examined the drug-resis...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Ma Y,Lan G,Li C,Cambaza EM,Liu D,Ye X,Chen S,Ding T

    更新日期:2019-08-01 00:00:00

  • Binding of enterotoxigenic Escherichia coli to isolated enterocytes and intestinal mucus.

    abstract::Binding of human enterotoxigenic Escherichia coli (ETEC) to the small intestine is a prerequisite for colonization and is mediated by colonization factor (CF) antigens. Coli surface antigen 6 (CS6) is considered a CF but binding to isolated enterocytes has not been established. In this study bacteria expressing CS6 we...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Helander A,Hansson GC,Svennerholm AM

    更新日期:1997-12-01 00:00:00

  • Salmonella Typhimurium induces cloacitis-like symptomsin zebrafish larvae.

    abstract::Pathogenic Salmonella strains have a set of virulence factors allowing them to generate systemic infections and damage in a variety of hosts. Among these factors, bacterial proteins secreted by specialized systems are used to penetrate the host's intestinal mucosa, through the invasion and destruction of specialized e...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Varas M,Ortíz-Severín J,Marcoleta AE,Díaz-Pascual F,Allende ML,Santiviago CA,Chávez FP

    更新日期:2017-06-01 00:00:00

  • Complete genome sequence of Bacillus licheniformis BL-010.

    abstract::The biodegradation of Aflatoxin B1 (AFB1) is an industry of increasing importance. Bacillus licheniformis BL-010 was isolated from the aflatoxin contaminated corn feed storage, and was shown to degrade AFB1 efficiently. Here we present the complete genome sequence of BL-010, the genome comprises 4,287,714 bp in a circ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: He S,Feng K,Ding T,Huang K,Yan H,Liu X,Zhang Z

    更新日期:2018-05-01 00:00:00

  • Biosynthesis of silver nanoparticles using a probiotic Bacillus licheniformis Dahb1 and their antibiofilm activity and toxicity effects in Ceriodaphnia cornuta.

    abstract::In the present study, we synthesized and characterized a probiotic Bacillus licheniformis cell free extract (BLCFE) coated silver nanoparticles (BLCFE-AgNPs). These BLCFE-AgNPs were characterized by UV-visible spectrophotometer, XRD, EDX, FTIR, TEM and AFM. A strong surface plasmon resonance centered at 422 nm in UV-v...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Shanthi S,Jayaseelan BD,Velusamy P,Vijayakumar S,Chih CT,Vaseeharan B

    更新日期:2016-04-01 00:00:00

  • Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant.

    abstract::Actinobacillus pleuropneumoniae is the pathogen of porcine contagious pleuropneumonia causing great economic losses globally. LuxS is known to be involved in the interspecies quorum sensing by mediating the production of AI-2 signal molecule and play important roles in regulating various behaviors of bacteria. In this...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Li L,Zhou R,Li T,Kang M,Wan Y,Xu Z,Chen H

    更新日期:2008-09-01 00:00:00

  • Analyzing the adhesion mechanism of FnBPA, a surface adhesin from Staphylococcus aureus on its interaction with nanoparticle.

    abstract::Staphylococcus aureus expresses many Microbial Surface Recognizing Adhesive Matrix Molecules (MSCRAMM's) to recognize host extracellular matrix (ECM) molecules to initiate colonization. The MSCRAMM, fibronectin binding protein A (FnBPA), is an important adhesin for S. aureus infection. FnBPA also binds with fibrinogen...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Ponnuvel S,Sankar S,Ponnuraj K

    更新日期:2020-09-01 00:00:00

  • The fingerprint mapping and genotyping systems application on methicillin-resistant Staphylococcus aureus.

    abstract::As a typical Gram-positive microorganism, S. aureus was recognized as common foodborne pathogenic bacteria in food industry. To study their individuality and pathogenicity mechanism, thirty-three Staphylococci strains were applied to the investigation with the identification of MRSA by PCR targeting on S. aureus speci...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Miao J,Wang W,Xu W,Su J,Li L,Li B,Zhang X,Xu Z

    更新日期:2018-12-01 00:00:00

  • Opa (protein II) influences gonococcal organization in colonies, surface appearance, size and attachment to human fallopian tube tissues.

    abstract::Opa-expressing variants of Neisseria gonorrhoeae strain F62-SF and an Opa- variant, all non-piliated, were examined for differences in the interaction of the bacteria within colonies and in attachment to and damage of human fallopian tube mucosa. Expression of certain Opas was associated with the formation of transpar...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Dekker NP,Lammel CJ,Mandrell RE,Brooks GF

    更新日期:1990-07-01 00:00:00

  • Purified Pasteurella haemolytica leukotoxin induces expression of inflammatory cytokines from bovine alveolar macrophages.

    abstract::We obtained biologically active purified leukotoxin (Lkt) from Pasteurella haemolytica serotypel, strain 12296 using preparative sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Three species of Lkt of molecular masses 95, 100, and 104 kDa were obtained. Purity of all three species of Lkt was conf...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Yoo HS,Rajagopal BS,Maheswaran SK,Ames TR

    更新日期:1995-04-01 00:00:00

  • Mycoplasma pneumoniae-related hepatitis in children.

    abstract::Mycoplasma pneumoniae (M. pneumoniae) is a small bacterium characterized by the absence of cell wall. It is a human pathogen causing upper and lower respiratory infections, both in adults and children. However, it is also considered to be implicated in the pathogenesis of several types of extra-respiratory diseases, i...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Poddighe D

    更新日期:2020-02-01 00:00:00

  • Non-dystrophic 129 REJ mice are susceptible to i.p. infection with Listeria monocytogenes despite an ability to recruit inflammatory neutrophils to the peritoneal cavity.

    abstract::In this study we compared the host response to Listeria monocytogenes in 129 REJ mice with listeria-resistant (C57Bl/6j) and susceptible (Balb/c) mouse strains. In all experiments mice were inoculated by the i.p. route. 129 REJ mice and Balb/c mice were sensitive to listeriosis whilst C57Bl/6j mice were relatively res...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Gahan CG,Collins JK

    更新日期:1995-05-01 00:00:00

  • Amphotericin B-conjugated biogenic silver nanoparticles as an innovative strategy for fungal infections.

    abstract::New strategies are required to improve the efficacy of drugs and to treat the emerging microbial resistance. An effective strategy is to combine drugs with metal nanoparticles for the control of microbial infections and resistance. Keeping in view this fact, we developed a facile and eco-friendly protocol for the synt...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Ahmad A,Wei Y,Syed F,Tahir K,Taj R,Khan AU,Hameed MU,Yuan Q

    更新日期:2016-10-01 00:00:00