Abstract:
:The first occurrences and dissemination of resistant microorganisms led to the inefficacy of many antibiotics, available in the market nowadays, therefore, the search for new substances with antimicrobial activity from natural sources has gained a great importance. The purpose of this work is to evaluate the antibacterial activity and modulation of drug resistance in Staphylococcus aureus by coumarins such as bergapten, xantotoxin, isopimpinellin and imperatorin obtained from two Rutaceae species (Metrodorea mollis and Pilocarpus spicatus). The antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC), using the microdilution method. The MIC was >256 g/mL for all coumarins tested. Regarding the modulation of drug resistance assay, the isopimpinellin reducted the MIC of erytromicin by 4 times, whereas imperatorin exhibited the best result, reducing the MIC of tetracycline (2 times), erytomicin (4 times) and norfloxacin (4 times). By reducing the MIC of ethidium bromide, the imperatorin is consider in fact, as a putative efflux pump inhibitor of bacteria.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Madeiro SA,Borges NH,Souto AL,de Figueiredo PT,Siqueira-Junior JP,Tavares JFdoi
10.1016/j.micpath.2017.01.028subject
Has Abstractpub_date
2017-03-01 00:00:00pages
151-154eissn
0882-4010issn
1096-1208pii
S0882-4010(16)30853-1journal_volume
104pub_type
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