Abstract：
:Streptococcus suis is an important pathogen in swine, and it also represents an emerging zoonotic agent. Zebrafish as a model for the evaluation of virulence of S. suis has been demonstrated before. Here, an Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish injected with S. suis serotype 2 strain HA9801. The results showed that 189 genes were differentially expressed, of which 125 genes were upregulated and 64 genes were downregulated. Gene Ontology category and KEGG pathway were analyzed for differentially expressed genes. Upregulated genes were involved in response to bacterium, immune response, inflammatory response, complement activation, defense response. Three genes (encoding serum amyloid protein A, matrix metalloproteinase 9 and apoptosis-related cysteine protease) and genes involved in the regulation of IL-6 biosynthetic process, which have previously been implicated in the response to S. suis infection in other organisms, were also upregulated. Downregulated genes played roles in glycolysis, carbohydrate metabolic process, amino acids metabolism, behavior and muscle. The reliability of the data obtained from the microarray was verified by performing quantitative real-time PCR on 12 representative genes. The data may provide further validation of this model, which will contribute to understanding of S. suis pathogenic mechanisms.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Wu Z,Zhang W,Lu Y,Lu Cdoi
10.1016/j.micpath.2010.02.007subject
Has Abstractpub_date
2010-05-01 00:00:00pages
178-87issue
5eissn
0882-4010issn
1096-1208pii
S0882-4010(10)00035-5journal_volume
48pub_type
杂志文章abstract：:Opportunistic infections, due to disease-related immunosuppression, constitute the major cause of death in American visceral leishmaniasis (AVL). Sera from these patients (AVL sera) non-specifically inhibit the in vitro proliferative response of normal human lymphocytes to lectins or antigens. In the present work, the...
journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
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更新日期：1999-05-01 00:00:00
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journal_title：Microbial pathogenesis
pub_type： 杂志文章,评审
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更新日期：2019-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.micpath.2019.103902
更新日期：2020-02-01 00:00:00
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
doi：10.1016/j.micpath.2010.11.008
更新日期：2011-06-01 00:00:00
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doi：10.1016/j.micpath.2019.02.025
更新日期：2019-05-01 00:00:00
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
doi：10.1016/j.micpath.2006.08.005
更新日期：2008-02-01 00:00:00
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journal_title：Microbial pathogenesis
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更新日期：2018-12-01 00:00:00
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
doi：10.1016/j.micpath.2017.12.040
更新日期：2018-02-01 00:00:00
abstract：:A common feature of many chlamydial infections is that they are often asymptomatic and may persist for long periods of time if left untreated. In addition to the well recognized lytic stage of the chlamydial developmental cycle, evidence is now emerging to support a persistent phase in the cycle in which the reticulat...
journal_title：Microbial pathogenesis
pub_type： 杂志文章
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abstract：OBJECTIVES:This study focused on the comparative genomic analyses of two qnrVC6 carrying Pseudomonas spp. strains which might give us insights on the similarity and difference in the genomic contexts of qnrVC6 gene. METHODS:Comparative genomic analyses of the novel qnrVC6 carrying Pseudomonas spp. genomes with emphasi...
journal_title：Microbial pathogenesis
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doi：10.1016/j.micpath.2018.07.026
更新日期：2018-10-01 00:00:00
