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Superior antibacterial activity of ZnO-CuO nanocomposite synthesized by a chemical Co-precipitation approach.

Abstract：

:Synthesis of highly efficient antibacterial agents has become highly important due to emergence of antibiotic resistance. Herein, Pristine ZnO and ZnO-CuO nanocomposite has been synthesized by simple chemical co-precipitation method and characterized by X-ray diffraction (XRD), microscopic and spectroscopic techniques. The prepared ZnO-CuO nanocomposite is composed of two dimensional nanosheets consisting of hexagonal ZnO and monoclinic CuO crystal phases present in coexistence. Moreover, a minute presence of Cu5Zn8 cubic phase has been evident in the XRD pattern of ZnO-CuO nanocomposite. Fourier Transform Infrared Spectroscopy (FTIR) spectrum of the prepared nanocomposite has revealed the presence of vibrational modes related to both Zn-O and Cu-O. Photoluminescence (PL) investigations depicted the formation of huge amounts of surface defects in ZnO-CuO nanocomposite as compared to pristine ZnO nanostructures. The prepared ZnO-CuO nanocomposite has efficiently killed Methicillin resistant Staphylococus aureus (s. aureus) bacterium by producing 24 mm of zone of inhibition (ZOI) comparing to 8 mm ZOI produced by pristine ZnO. The superior antibacterial activity of ZnO-CuO nanocomposite has been attributed to oxidative stress generated by electron transfer pathway and reactive oxygen species (ROS) generation.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Jan T,Azmat S,Mansoor Q,Waqas HM,Adil M,Ilyas SZ,Ahmad I,Ismail M

doi

10.1016/j.micpath.2019.103579

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

103579

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(18)31645-0

journal_volume

134

pub_type

杂志文章

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