当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > Resveratrol improves efficacy of oral amoxicillin against childhood fast breathing pneumonia in a randomized placebo-controlled double blind clinical trial.

Resveratrol improves efficacy of oral amoxicillin against childhood fast breathing pneumonia in a randomized placebo-controlled double blind clinical trial.

Abstract：

:Childhood pneumonia has been considered as a major cause of child morbidity and mortality worldwide. We aimed to investigate the effect of resveratral in synergizing with oral amoxicillin to improve the treatment outcome of oral amoxicillin administration against childhood fast breathing pneumonia. 647 children diagnosed fast breathing pneumonia were recruited and randomized to receive oral amoxicillin plus either resveratrol (AX + RV) or placebo (AX + placebo). The primary outcome was defined as treatment failure up to day 3, while the secondary outcome was defined as treatment failure at day 6 and 12 upon follow up. Incidences of treatment failure up to day 3 was significantly lower in the AX + RV group than the AX + placebo group. From day 6-12, the incidences of treatment failure were increased in both treatment groups. However, treatment failure cases were still much lower in the AX + RV group on both revisits. No serious adverse reaction to treatment drugs were found in either of the two groups. Resveratrol improves efficacy of oral amoxicillin against childhood fast breathing pneumonia, supporting the clincial potential of reseveratrol as a potent adjuvent of oral amoxicillin in the treatment of childhood pneumonia with no adverse effects.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Qiang L,Di Y,Jiang Z,Xu J

doi

10.1016/j.micpath.2017.11.062

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

209-212

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(17)31434-1

journal_volume

114

pub_type

杂志文章,随机对照试验

相关文献

MICROBIAL PATHOGENESIS文献大全
  • Identification of proteins involved in the adhesionof Candida species to different medical devices.

    abstract：:Adhesion is the first step for Candida species to form biofilms on medical devices implanted in the human host. Both the physicochemical nature of the biomaterial and cell wall proteins (CWP) of the pathogen play a determinant role in the process. While it is true that some CWP have been identified in vitro, little is...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.04.009

    authors： Núñez-Beltrán A,López-Romero E,Cuéllar-Cruz M

    更新日期：2017-06-01 00:00:00

  • In silico analysis of four structural proteins of aphthovirus serotypes revealed significant B and T cell epitopes.

    abstract：:Foot and Mouth disease (FMD) is economically devastating, highly contagious transboundry viral disease of livestock with 100% morbidity, rapid spread and severe production losses in animals. The FMDV has seven different serotypes. There is no vaccine that can protect animals from all serotypes. Hence, it is need of th...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.01.007

    authors： Raza S,Siddique K,Rabbani M,Yaqub T,Anjum AA,Ibrahim M,Azhar M,Jamil F,Rasheed MA

    更新日期：2019-03-01 00:00:00

  • Antimicrobial activity of crude fractions and morel compounds from wild edible mushrooms of North western Himalaya.

    abstract：:The antimicrobial properties of morel compounds from wild edible mushrooms (Morchella esculenta and Verpa bohemica) from Kashmir valley was investigated against different clinical pathogens. The butanol crude fraction of most popular or true morel M. esculenta showed highest 19 mm IZD against E.coli while as same frac...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.03.005

    authors： Shameem N,Kamili AN,Ahmad M,Masoodi FA,Parray JA

    更新日期：2017-04-01 00:00:00

  • Identification of putative virulence-associated genes among Haemophilus parasuis strains and the virulence difference of different serovars.

    abstract：:This study was aimed at determining virulence-associated genes among Haemophilus parasuis (H. parasuis) strains, and supplying for the Kielstein-Rapp-Gabrielson serotyping scheme. The subtractive fragments, obtained through suppression subtractive hybridization and reverse Southern blot hybridization, were found to en...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2014.10.001

    authors： Yu J,Wu J,Zhang Y,Du Y,Peng J,Chen L,Sun W,Cong X,Xu S,Shi J,Li J,Huang B,Zhu X,Wang J

    更新日期：2014-12-01 00:00:00

  • Identification of Synergistetes in endodontic infections.

    abstract：:The bacterial phylum Synergistetes consists of Gram-negative anaerobes. Oral Synergistetes are divided in two main clusters, namely A and B. Increasing evidence demonstrates their involvement in etiology of oral infections, including apical periodontitis. This condition causes bone loss around the apex of the tooth, s...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2014.05.001

    authors： Fernandes Cdo C,Rechenberg DK,Zehnder M,Belibasakis GN

    更新日期：2014-08-01 00:00:00

  • Isolation and characterization of the non-fimbrial adhesin NFA-4 from uropathogenic Escherichia coli O7:K98:H6.

    abstract：:The non-fimbrial adhesin NFA-4 from uropathogenic Escherichia coli O7:K98:H6 mediates the agglutination of human red cells (RBC), notably of blood group MM. The adhesin can be separated from the bacteria by heat extraction and was purified to homogeneity by ammonium sulphate precipitation and anion exchange chromatogr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(89)90077-6

    authors： Hoschützky H,Nimmich W,Lottspeich F,Jann K

    更新日期：1989-05-01 00:00:00

  • Development of inflammation and augmented chemotactic responsiveness of murine peritoneal macrophages following treatment with Entamoeba histolytica trophozoites.

    abstract：:The accumulation of inflammatory cells in the peritoneal cavity of C57BL/6 mice was examined following intraperitoneal injection of Entamoeba histolytica trophozoites. Two different strains of E. histolytica were used: a virulent strain (IP:0682:1) and a non-virulent strain (DKB). Injection of 10(6) trophozoites of ei...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(87)90097-0

    authors： Ghadirian E,Stevenson MM

    更新日期：1987-09-01 00:00:00

  • Identification of 60 secreted proteins for Mycoplasma bovis with secretome assay.

    abstract：:Mycoplasma bovis is a risky pathogen mainly responsible for pneumonia and mastitis in cattle. Up to date, its pathogenesis is not clear. Since secreted proteins have a tricky role in M. bovis pathogenesis, this study was designed to systematically reveal M. bovis secretome and potential role in virulence of the pathog...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104135

    authors： Zubair M,Muhamed SA,Khan FA,Zhao G,Menghwar H,Faisal M,Zhang H,Zhu X,Rasheed MA,Chen Y,Marawan MA,Chen H,Guo A

    更新日期：2020-06-01 00:00:00

  • Morphological characterization and biocontrol effects of Vibrio vulnificus phages against Vibriosis in the shrimp aquaculture environment.

    abstract：:The re-emerging field of phage therapy is the potential biocontrol agents for the transfer of virulence factor and to kill their bacterial hosts. In this study, the lytic Vibrio vulnificus phages were studied to provide a better understanding of phage-host interactions and development of phage therapy. Four new V. vul...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.09.024

    authors： Srinivasan P,Ramasamy P

    更新日期：2017-10-01 00:00:00

  • Correlation between ability of biofilm formation with their responsible genes and MDR patterns in clinical and environmental Acinetobacter baumannii isolates.

    abstract：:Acinetobacter baumannii potential to form biofilm and exhibit multiple antibiotic resistances may be responsible in its survival in hospital environment. Accordingly, our study was aimed to determine the correlation between ability of biofilm formation and the frequency of biofilm related genes with antibiotic resista...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.04.039

    authors： Bardbari AM,Arabestani MR,Karami M,Keramat F,Alikhani MY,Bagheri KP

    更新日期：2017-07-01 00:00:00

  • Impact of QseBC system in c-di-GMP-dependent quorum sensing regulatory network in a clinical isolate SSU of Aeromonas hydrophila.

    abstract：:Our earlier studies showed that AhyRI- (AI-1) and LuxS-based (AI-2) quorum sensing (QS) systems were positive and negative regulators of virulence, respectively, in a diarrheal isolate SSU of Aeromonas hydrophila. Recently, we demonstrated that deletion of the QseBC two-component signal transduction system (AI-3 QS in...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2012.05.008

    authors： Kozlova EV,Khajanchi BK,Popov VL,Wen J,Chopra AK

    更新日期：2012-09-01 00:00:00

  • Fecal bacteria from Crohn's disease patients more potently activated NOD-like receptors and Toll-like receptors in macrophages, in an IL-4-repressible fashion.

    abstract：:Crohn's disease (CD) is characterized by a pathogenic intestinal inflammation mediated by a Th1-skewed immune system and a dysregulated intestinal mucosal community. In this study, we investigated the role of bacteria on the activation and function of monocytes, and its association with CD pathogenesis. To this end, f...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.05.009

    authors： Gu J,Liu G,Xing J,Song H,Wang Z

    更新日期：2018-08-01 00:00:00

  • Intracellular changes of a swine tracheal cell line infected with a Mycoplasma hyopneumoniae pathogenic strain.

    abstract：:Mycoplasma hyopneumoniae is the etiological agent of enzootic pneumonia (EP), a widespread disease that causes major economic losses to the pig industry. The swine host response plays an important role in the outcome of M. hyopneumoniae infections. The whole proteome of newborn pig trachea (NPTr) epithelial cells infe...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103717

    authors： Leal Zimmer FMA,Moura H,Barr JR,Ferreira HB

    更新日期：2019-12-01 00:00:00

  • An endophytic strain JK of genus bacillus isolated from the seeds of super hybrid rice (Oryza sativa L., Shenliangyou 5814) has antagonistic activity against rice blast pathogen.

    abstract：:Rice is an important food crop in the world, and rice blast is one of the major fungal diseases that cause large-scale rice yield reduction. This study aimed to investigate the antagonistic activity and its molecular mechanism of bacterial strain JK isolated from seeds of super hybrid rice 'Shenliangyou 5814' (Oryza s...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104422

    authors： Jing R,Li N,Wang W,Liu Y

    更新日期：2020-10-01 00:00:00

  • Host-directed therapies to combat tuberculosis and associated non-communicable diseases.

    abstract：:Mycobacterium tuberculosis (Mtb) has coevolved with a human host to evade and exploit the immune system in multiple ways. Mtb is an enormously successful human pathogen that can remain undetected in hosts for decades without causing clinical disease. While tuberculosis (TB) represents a perfect prototype of host-patho...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2019.03.003

    authors： Baindara P

    更新日期：2019-05-01 00:00:00

  • The luxS gene functions in the pathogenesis of avian pathogenic Escherichia coli.

    abstract：:Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, the most significant infectious bacterial disease of poultry worldwide. LuxS, the product of the luxS gene, mediates the quorum sensing (QS) mechanism. This involves the production of autoinducer-2 (AI-2), which regulates important physiological tra...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2012.09.008

    authors： Han X,Bai H,Liu L,Dong H,Liu R,Song J,Ding C,Qi K,Liu H,Yu S

    更新日期：2013-02-01 00:00:00

  • Entry and intracellular replication of Mycobacterium tuberculosis in cultured human microvascular endothelial cells.

    abstract：:Establishment of pulmonary Mycobacterium tuberculosis infection requires evasion of host innate defenses. In the lung alveoli, epithelial cells naturally resist uptake by the inhaled bacilli while macrophages patrol the epithelial surface and phagocytose foreign microbes. Alveolar microvascular endothelial cells, howe...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2006.05.002

    authors： Mehta PK,Karls RK,White EH,Ades EW,Quinn FD

    更新日期：2006-08-01 00:00:00

  • Sendai virus infection of normal and protein malnourished mice: response of airway leukocytes to infection.

    abstract：:We examined the cells recovered by bronchoalveolar lavage (BAL) during the course of respiratory infection caused by Sendai virus in normal (20% protein diet) and malnourished (2% protein diet) mice. As in our previous experiments, mortality in normal mice was 32% in comparison with 87% in the malnourished group. Viru...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(91)90045-c

    authors： Lee HJ,Moody CT,Reiss CS,Peña-Cruz V,McIntosh K

    更新日期：1991-09-01 00:00:00

  • Identification and characterization of the ribosome-associated protein, HrpA, of Bacillus Calmette-Guérin.

    abstract：:HrpA was found as a ribosome-associated protein which appeared in heat-stressed Mycobacterium bovis Bacillus Calmette-Guérin. Here, we have studied the function of HrpA in vitro. HrpA is a heat shock protein belonging to a small heat shock protein family. The putative molecular mass was 17784.86 kDa. Recombinant HrpA ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0384

    authors： Tabira Y,Ohara N,Yamada T

    更新日期：2000-10-01 00:00:00

  • Acyl homoserine lactone changes the abundance of proteins and the levels of organic acids associated with stationary phase in Salmonella Enteritidis.

    abstract：:Quorum sensing (QS) is cell-cell communication mechanism mediated by signaling molecules known as autoinducers (AIs) that lead to differential gene expression. Salmonella is unable to synthesize the AI-1 acyl homoserine lactone (AHL), but is able to recognize AHLs produced by other microorganisms through SdiA protein....

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.11.027

    authors： de Almeida FA,Pimentel-Filho NJ,Carrijo LC,Bento CBP,Baracat-Pereira MC,Pinto UM,de Oliveira LL,Vanetti MCD

    更新日期：2017-01-01 00:00:00

  • Nucleotide sequence and expression of an extracellular hemolysin gene of Aeromonas hydrophila.

    abstract：:The extracellular hemolysin (AHH1) gene of Aeromonas hydrophila ATCC7966 was cloned into Charomid9-28 in Escherichia coli DH1, and its complete nucleotide sequence determined. Escherichia coli carrying this gene expressed an extracellular heat-labile hemolysin for rabbit red blood cells. The minimum size of the coding...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(91)90049-g

    authors： Hirono I,Aoki T

    更新日期：1991-09-01 00:00:00

  • Purification and some properties of a Vero toxin 2 (Shiga-like toxin II) variant (SLT-IIva) of Escherichia coli isolated from infantile diarrhea.

    abstract：:A variant of Vero toxin 2 (VT2), or Shiga-like toxin II (SLT-II) was purified from a cloned strain of Escherichia coli carrying a gene that encodes SLT-IIva, which is most closely related to SLT-IIv (VT2vp, VTe) in its nucleotide sequence. The purified SLT-IIva showed a slight difference from the purified SLT-IIv (VT2...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1993.1089

    authors： Ohmura M,Cao C,Karasawa T,Okuda J,Kurazono H,Gannon VP,Gyles CL,Takeda Y

    更新日期：1993-11-01 00:00:00

  • Biofilm inhibitory effect of chlorhexidine conjugated gold nanoparticles against Klebsiella pneumoniae.

    abstract：:Klebsiella pneumoniae (K. pneumoniae) is one of the major pathogen associated with nosocomial infections, especially catheter associated urinary tract infections which involved biofilm formation. This study was designed to evaluate the antibiofilm efficacy of gold nanoparticle conjugated with chlorhexidine (Au-CHX) ag...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.06.016

    authors： Ahmed A,Khan AK,Anwar A,Ali SA,Shah MR

    更新日期：2016-09-01 00:00:00

  • Mycoplasma pneumoniae-related hepatitis in children.

    abstract：:Mycoplasma pneumoniae (M. pneumoniae) is a small bacterium characterized by the absence of cell wall. It is a human pathogen causing upper and lower respiratory infections, both in adults and children. However, it is also considered to be implicated in the pathogenesis of several types of extra-respiratory diseases, i...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103863

    authors： Poddighe D

    更新日期：2020-02-01 00:00:00

  • Opsonization of Staphylococcus aureus with a fibronectin-binding protein antiserum induces protection in mice.

    abstract：:The virulence of Staphylococcus aureus opsonized with an antiserum raised against a recombinant fibronectin-binding protein (FnBP) was compared with homologous, non-opsonized bacteria (treated with pre-immune serum) in a mouse mastitis model. Virulence was evaluated comparing the number of bacteria removed from the in...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1995.0044

    authors： Mamo W,Jonsson P,Müller HP

    更新日期：1995-07-01 00:00:00

  • Alveolar microbiota profile in patients with human pulmonary tuberculosis and interstitial pneumonia.

    abstract：BACKGROUND:The presence of the human lung microbiota has been demonstrated in patients with different lung diseases, mainly in sputum samples. However, for study of the alveolar microbiota, a bronchoalveolar lavage (BAL) sample represents the lower respiratory tract (LRT) environment. It is currently unknown whether th...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103851

    authors： Vázquez-Pérez JA,Carrillo CO,Iñiguez-García MA,Romero-Espinoza I,Márquez-García JE,Falcón LI,Torres M,Herrera MT

    更新日期：2020-02-01 00:00:00

  • Regulation of NF-κB/MAPK signaling pathway attenuates the acute lung inflammation in Klebsiella pneumonia rats by mollugin treatment.

    abstract：:Present study evaluates the protective effect of mollugin against Klebsiella pneumonia (KP) and also postulates the possible mechanism of its action. Klebsiella pneumoniae (2.4 × 108 CFU/ml) was used for the induction of KP. PMNs and WBC count was determined in the blood and bronchoalveolar lavage fluid (BALF) of Kleb...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.05.007

    authors： Zhang Y,Zhou S,Zhou J,Wang D,Zhou T

    更新日期：2019-07-01 00:00:00

  • Pros and cons of direct genotyping on tuberculosis clinical samples.

    abstract：OBJECTIVE:Prompt genotyping of Mycobacterium tuberculosis (M. tuberculosis) is crucial for improving molecular epidemiological investigation of tuberculosis (TB). METHODS:We performed a retrospective study to evaluate the use of 24 loci MIRU-VNTR (mycobacterial interspersed repetitive unit-variable number of tandem-re...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.12.025

    authors： Sadegh H,Kargarpour Kamakoli M,Farmanfarmaei G,Masoumi M,Abdolrahimi F,Fateh A,Ebrahimzadeh N,Rahimi Jamnani F,Vaziri F,Siadat SD

    更新日期：2017-02-01 00:00:00

  • Vancomycin-induced biofilm formation by methicillin-resistant Staphylococcus aureus is associated with the secretion of membrane vesicles.

    abstract：:Chronic burn wound infections caused by Stapyhylococcus aureus (S. aureus) are largely associated with biofilm formation. However, the mechanism by which S. aureus form biofilm in clinical environments is far less understood. In the present study we addressed the association between biofilm formation and membrane vesi...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.07.004

    authors： He X,Yuan F,Lu F,Yin Y,Cao J

    更新日期：2017-09-01 00:00:00

  • Binding of enterotoxigenic Escherichia coli to isolated enterocytes and intestinal mucus.

    abstract：:Binding of human enterotoxigenic Escherichia coli (ETEC) to the small intestine is a prerequisite for colonization and is mediated by colonization factor (CF) antigens. Coli surface antigen 6 (CS6) is considered a CF but binding to isolated enterocytes has not been established. In this study bacteria expressing CS6 we...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1997.0163

    authors： Helander A,Hansson GC,Svennerholm AM

    更新日期：1997-12-01 00:00:00