Abstract:
:We examined the cells recovered by bronchoalveolar lavage (BAL) during the course of respiratory infection caused by Sendai virus in normal (20% protein diet) and malnourished (2% protein diet) mice. As in our previous experiments, mortality in normal mice was 32% in comparison with 87% in the malnourished group. Virus was isolated until the 5th day in normally fed mice and until the 9th day in the malnourished group. BAL fluids contained 97% macrophages before infection in both groups. During infection there was a progressive lymphocyte response, reaching a peak of 60-70% on day 5 in the normal mice and on days 7-9 in the malnourished group. Subtyping of BAL cells by flow cytometry indicated that in uninfected animals lymphocytes were largely CD4-bearing. On days 3 and 5 post-infection most mononuclear cells were Thy 1.2-positive, but lacked both CD4 and CD8 markers and were therefore probably natural killer cells. Beginning on day 5, in both diet groups CD8-positive cells rose to become the predominant subset. In the 20% protein diet group, CD8-positive cells reached a maximum of 60% on day 7, whereas in the 2% protein diet group this level was not reached until day 9. These results were consistent in three separate experiments. In malnourished mice the delayed appearance of CD8-bearing cells in the airway may contribute to the higher mortality and delayed virus clearance during Sendai virus infection.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Lee HJ,Moody CT,Reiss CS,Peña-Cruz V,McIntosh Kdoi
10.1016/0882-4010(91)90045-csubject
Has Abstractpub_date
1991-09-01 00:00:00pages
149-57issue
3eissn
0882-4010issn
1096-1208pii
0882-4010(91)90045-Cjournal_volume
11pub_type
杂志文章abstract::Inflammasome activation is an important host response to infectious diseases, but the difference in inflammasome activation between typhoid fever and non-typhoidal Salmonella infection has been rarely studied. To determine whether inflammasome activation in macrophages after S. Typhi and S. Typhimurium infection is di...
journal_title:Microbial pathogenesis
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更新日期:2020-09-01 00:00:00
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/0882-4010(92)90049-t
更新日期:1992-04-01 00:00:00
abstract::Dendritic cells (DCs) are key linkages between innate immunity and acquired immunity. The antigens that promote the functions of DCs might be the effective candidates of novel vaccine. In this research, the ability of ubiquitin-conjugating enzyme (UCE), a recognized common antigens among chicken Eimeria species, to st...
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/0882-4010(91)90049-g
更新日期:1991-09-01 00:00:00
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2012.10.002
更新日期:2013-03-01 00:00:00
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journal_title:Microbial pathogenesis
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pub_type: 杂志文章
doi:10.1016/j.micpath.2018.01.008
更新日期:2018-03-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 评论,信件
doi:10.1016/j.micpath.2012.09.013
更新日期:2013-02-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1006/mpat.1993.1018
更新日期:1993-03-01 00:00:00
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2020.104513
更新日期:2020-12-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2014.05.001
更新日期:2014-08-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章,meta分析
doi:10.1016/j.micpath.2012.05.007
更新日期:2012-08-01 00:00:00
abstract::The macrophage innate immune response is outlined through recognition of the components of Mycobacterium tuberculosis. DNA of M. tuberculosis (MtbDNA) is recognized by macrophages, but the implications of this recognition are poorly characterized. Stimulation of murine macrophages with MtbDNA induces autophagy, a proc...
journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2019.04.041
更新日期:2019-07-01 00:00:00
abstract::This study was undertaken to determine the genotypic distribution of Chinese M. bovis strains and their similarity to isolates from other countries. Two multilocus sequence typing (MLST) schemes (MLST-1 and MLST-2) and pulsed field gel electrophoresis (PFGE) were used to compare 44 Chinese strains and the M. bovis typ...
journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2017.08.029
更新日期:2017-10-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/0882-4010(92)90095-6
更新日期:1992-05-01 00:00:00
abstract::Elimination of pathogenic microorganisms in the liver may be an important effector mechanism in host defenses. In this paper we describe the adhesion, invasion and multiplication of Salmonella typhimurium in a murine embryonic hepatocyte cell line (ATCC TIB-73). Monolayers of hepatocytes treated with recombinant IFN g...
journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1006/mpat.1996.0065
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doi:10.1016/j.micpath.2016.02.021
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更新日期:2021-01-05 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
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journal_title:Microbial pathogenesis
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更新日期:1997-07-01 00:00:00
abstract::Helicobacter pylori (H. pylori) usually colonizes the gastric mucosa of more than 50% of the human population, causing an infection that may appear in early childhood and can persist for life. H. pylori is suggested as the main cause of peptic ulcer and chronic gastritis. It is also associated with gastric cancer. Its...
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pub_type: 杂志文章,评审
doi:10.1016/j.micpath.2016.09.016
更新日期:2016-11-01 00:00:00
abstract::Moritella viscosa is the aetiological agent of winter-ulcer disease in farmed salmonids in the North Atlantic. Previously, two major (typical and variant) genetic clades have been demonstrated within this bacterial species, one of which is almost solely related to disease in Atlantic salmon (Salmo salar). In the prese...
journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2014.09.014
更新日期:2014-12-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/0882-4010(91)90022-3
更新日期:1991-11-01 00:00:00
abstract::We previously demonstrated that incubation of E. coli in normal human serum (NHS) resulted in the release of a finite fraction (approximately 30%) of LPS from the bacterial outer membrane. In experiments reported here, we examined factors which may enhance or diminish the capacity of NHS to mediate this limited LPS re...
journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/0882-4010(88)90068-x
更新日期:1988-03-01 00:00:00
abstract::Porphyromonas gingivalis is capable of in vitro growth when iron sources are either complexed to hemin or host iron transport proteins, or exist in an inorganic form. This study examined the effect of these iron sources on outer membrane protein (OMP) expression in P. gingivalis W50. Hemin (iron) starved P. gingivalis...
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pub_type: 杂志文章
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