当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > A role for sigma factor B in the emergence of Staphylococcus aureus small-colony variants and elevated biofilm production resulting from an exposure to aminoglycosides.

A role for sigma factor B in the emergence of Staphylococcus aureus small-colony variants and elevated biofilm production resulting from an exposure to aminoglycosides.

Abstract：

:Staphylococcus aureus small-colony variants (SCVs) and biofilms are linked to chronic infections. It is known that the presence of aminoglycoside antibiotics may contribute to the emergence of SCVs and it is thought that molecular mechanisms are involved in the ability of S. aureus to adopt this phenotype. No study has addressed the possible role of the stress- and colonization-related alternative sigma factor B (SigB) in the emergence of SCVs, although a sustained SigB activity was reported in these variants. Here, we demonstrate that SigB is involved in the emergence of SCVs resulting from an exposure to a sub-inhibitory concentration of aminoglycosides. Monitoring of gene expression in an aminoglycoside-treated prototypical strain or in clinical SCVs showed the activation of SigB, whereas the accessory gene regulator (agr) system was not. Furthermore, gentamicin-treated prototypical bacteria and SCVs had an increased ability to form biofilm only in a SigB functional background. The administration of a sub-inhibitory concentration of gentamicin significantly increased the formation of SCVs for a prototypical strain but not for the sigB mutant in a mouse model of S. aureus-induced mastitis. Collectively, our results show that SigB may positively influence the appearance of S. aureus SCVs and the production of biofilm upon aminoglycoside exposure.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Mitchell G,Brouillette E,Séguin DL,Asselin AE,Jacob CL,Malouin F

doi

10.1016/j.micpath.2009.10.003

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

18-27

issue

1

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(09)00164-8

journal_volume

48

pub_type

杂志文章

相关文献

MICROBIAL PATHOGENESIS文献大全
  • Macrophage--Mycobacterium tuberculosis interactions: role of complement receptor 3.

    abstract：:Tuberculosis is the leading infectious disease in the world. Mycobacterium tuberculosis, the causal agent of this disease, invades macrophages and can replicate inside them. Because invasion of macrophages is a critical step for establishing a mycobacterial infection, there is much interest in understanding the mechan...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/s0882-4010(03)00099-8

    authors： Velasco-Velázquez MA,Barrera D,González-Arenas A,Rosales C,Agramonte-Hevia J

    更新日期：2003-09-01 00:00:00

  • Broad-spectrum quorum sensing and biofilm inhibition by green tea against gram-negative pathogenic bacteria: Deciphering the role of phytocompounds through molecular modelling.

    abstract：:The emerging prevalence of multidrug-resistance in Gram-negative pathogens, due to conventional antimicrobial therapeutics, has led the researchers to emphasize on development of alternative novel strategies to suppress the bacterial virulence and pathogenicity through inhibition of quorum sensing (QS) and biofilms. Q...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.11.030

    authors： Qais FA,Khan MS,Ahmad I

    更新日期：2019-01-01 00:00:00

  • Ginsenoside Rb 1: A novel therapeutic agent in Staphylococcusaureus-induced Acute Lung Injury with special reference to Oxidative stress and Apoptosis.

    abstract：:Acute lung injury (ALI) is considered as an uncontrolled inflammatory response that can leads to acute respiratory distress syndrome (ARDS), which limits the therapeutic strategies. Ginsenosides Rb1 (Rb1), an active ingredient obtained from Panax ginseng, possesses a broad range of pharmacological and medicinal proper...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104109

    authors： Shaukat A,Yang C,Yang Y,Guo YF,Jiang K,Guo S,Liu J,Zhang T,Zhao G,Ma X,Wu Z,Zhou Q,Akhtar M,Zahoor A,Umar T,Shaukat I,Hanif S,Rajput SA,Hassan M,Mehmood K,Hua Z,Xiaoyan W,Nannan Y,Deng G

    更新日期：2020-06-01 00:00:00

  • High-resolution melting-curve (HRM) analysis for C. meleagridis identification in stool samples.

    abstract：BACKGROUND:Cryptosporidiosis represents a major public health problem. This infection, caused by a protozoan parasite of the genus Cryptosporidium, has been reported worldwide as a frequent cause of diarrhoea. In the immunocompetent host, the typical watery diarrhea can be self-limiting. However, it is severe and chron...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.12.070

    authors： Chelbi H,Essid R,Jelassi R,Bouzekri N,Zidi I,Ben Salah H,Mrad I,Ben Sghaier I,Abdelmalek R,Aissa S,Bouratbine A,Aoun K

    更新日期：2018-02-01 00:00:00

  • Interplay between MgtC and PagC in Salmonella enterica serovar Typhimurium.

    abstract：:In Salmonella enterica serovar Typhimurium, MgtC and PagC are positively regulated by the PhoP-PhoQ two-component system, which is activated under magnesium deprivation. Both MgtC and PagC are of unknown function but have been involved in intramacrophage survival. We have found that the amount of PagC is lowered in a ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2008.06.001

    authors： Alix E,Miki T,Felix C,Rang C,Figueroa-Bossi N,Demettre E,Blanc-Potard AB

    更新日期：2008-09-01 00:00:00

  • Antitumor effect of exopolysaccharide produced by Bacillus mycoides.

    abstract：:Recently, microbial exopolysaccharides (EPSs) have offered very large field for medical applications owing to their bioactive characteristics. This study aimed to obtain antitumor EPS and to optimize its production using different optimization approaches. Eighty EPSs-producing bacteria were obtained from mud samples. ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103947

    authors： Farag MMS,Moghannem SAM,Shehabeldine AM,Azab MS

    更新日期：2020-03-01 00:00:00

  • Evaluation of culture conditions for mixed biofilm formation with clinically isolated non-albicans Candida species and Staphylococcus epidermidis on silicone.

    abstract：:Silicone is frequently used in clinical and medical fields for medical devices. Mixed biofilms composed of Candida and bacterial species causes frequently failure of medical silicone devices, In this in vitro study, we analyzed mixed biofilm formation of clinically isolated non-albicans Candida species and Staphylococ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.10.002

    authors： Tan Y,Leonhard M,Schneider-Stickler B

    更新日期：2017-11-01 00:00:00

  • Treponema denticola invasion into human gingival epithelial cells.

    abstract：:Host cell invasion is important for periodontal pathogens in evading host defenses and spreading into deeper areas of the periodontal tissue. Treponema denticola has been implicated in a number of potentially pathogenic processes, including periodontal tissue penetration. Here we tested the ability of T. denticola str...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.01.010

    authors： Inagaki S,Kimizuka R,Kokubu E,Saito A,Ishihara K

    更新日期：2016-05-01 00:00:00

  • Distribution of virulence genes and genotyping of CTX-M-15-producing Klebsiella pneumoniae isolated from patients with community-acquired urinary tract infection (CA-UTI).

    abstract：:Klebsiella pneumoniae is one of the most important agents of community-acquired urinary tract infection (CA-UTI). In addition to extended-spectrum β-lactamases (ESBLs), a number of virulence factors have been shown to play an important role in the pathogenesis of K. pneumoniae, including capsule, siderophores, and adh...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.10.002

    authors： Ranjbar R,Memariani H,Sorouri R,Memariani M

    更新日期：2016-11-01 00:00:00

  • Molecular survey and characterization of Trypanosoma evansi in naturally infected camels with suspicion of a Trypanozoon infection in horses by molecular detection in Egypt.

    abstract：:In Egypt, although the Trypanosoma evansi has been reported frequently among domestic animals, there is no published data on T. evansi in horses. Therefore, this study aimed to assess the prevalence and characterization of T. evansi in three governorates by examining blood samples from 40 local camels, 35 imported cam...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.07.017

    authors： Elhaig MM,Sallam NH

    更新日期：2018-10-01 00:00:00

  • Opa (protein II) influences gonococcal organization in colonies, surface appearance, size and attachment to human fallopian tube tissues.

    abstract：:Opa-expressing variants of Neisseria gonorrhoeae strain F62-SF and an Opa- variant, all non-piliated, were examined for differences in the interaction of the bacteria within colonies and in attachment to and damage of human fallopian tube mucosa. Expression of certain Opas was associated with the formation of transpar...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(90)90037-q

    authors： Dekker NP,Lammel CJ,Mandrell RE,Brooks GF

    更新日期：1990-07-01 00:00:00

  • Transcription of bovine leukemia virus in peripheral blood cells obtained during early infection in vivo.

    abstract：:Bovine leukemia virus (BLV) is transcriptionally silent in most circulating peripheral blood mononuclear cells (PBMCs) of animals with well-established infections. Using PBMCs from a newly infected sheep, we asked whether viral transcription proceeded differently during the initial months of infection, when the preval...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(92)90095-6

    authors： Radke K,Sigala TJ,Grossman D

    更新日期：1992-05-01 00:00:00

  • Antibacterial and antibiofilm activities of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against periodontopathic bacteria.

    abstract：:Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are two major omega-3 polyunsaturated fatty acids (n-3 PUFAs) with antimicrobial properties. In this study, we evaluated the potential antibacterial and antibiofilm activities of DHA and EPA against two periodontal pathogens, Porphyromonas gingivalis (P. gingi...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.08.025

    authors： Sun M,Zhou Z,Dong J,Zhang J,Xia Y,Shu R

    更新日期：2016-10-01 00:00:00

  • Effect of two monoterpene phenols on antioxidant defense system in Candida albicans.

    abstract：:Thymol and carvacrol from the class of monoterpene phenols are one of the most potent plant essential oil components possessing antimicrobial effects. Known for their wide bioactive spectrum, these positional isomers of isopropyl cresol deplete ergosterol content, compromise membrane permeability, block efflux pumps a...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2015.02.004

    authors： Khan A,Ahmad A,Ahmad Khan L,Padoa CJ,van Vuuren S,Manzoor N

    更新日期：2015-03-01 00:00:00

  • The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus.

    abstract：:An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by insertional mutagenesis, and the MdaB protein was purified and compared to the Helicobacter pylori enzyme. While wild type H. hepaticus cells could tolerate 6% O(2) for growth, the mdaB strain was cle...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2006.08.005

    authors： Hong Y,Wang G,Maier RJ

    更新日期：2008-02-01 00:00:00

  • The characterization of bacterial communities of oropharynx microbiota in healthy children by combining culture techniques and sequencing of the 16S rRNA gene.

    abstract：:The high incidence of bacterial respiratory infections has led to a focus on evaluating the human respiratory microbiome. Studies based on culture-based and molecular methods have shown an increase in the bacterial community that includes the bacterial phyla Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteri...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104115

    authors： Maleki A,Zamirnasta M,Taherikalani M,Pakzad I,Mohammadi J,Krutova M,Kouhsari E,Sadeghifard N

    更新日期：2020-06-01 00:00:00

  • Characterization of non-aflatoxigenic strains of Aspergillus flavus as potential biocontrol agent for the management of aflatoxin contamination in groundnut.

    abstract：:In the present study, nine non-aflatoxigenic Aspergillus flavus strains were evaluated for their potential to reduce A. flavus infection and aflatoxin contamination in groundnut. Genetic characterization of these strains revealed six different deletion patterns (A-F) for thirteen examined genes from the aflatoxin bios...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.11.007

    authors： Hulikunte Mallikarjunaiah N,Jayapala N,Puttaswamy H,Siddapura Ramachandrappa N

    更新日期：2017-01-01 00:00:00

  • Identification of 60 secreted proteins for Mycoplasma bovis with secretome assay.

    abstract：:Mycoplasma bovis is a risky pathogen mainly responsible for pneumonia and mastitis in cattle. Up to date, its pathogenesis is not clear. Since secreted proteins have a tricky role in M. bovis pathogenesis, this study was designed to systematically reveal M. bovis secretome and potential role in virulence of the pathog...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104135

    authors： Zubair M,Muhamed SA,Khan FA,Zhao G,Menghwar H,Faisal M,Zhang H,Zhu X,Rasheed MA,Chen Y,Marawan MA,Chen H,Guo A

    更新日期：2020-06-01 00:00:00

  • Antioxidant defense response induced by Trichoderma viride against Aspergillus niger Van Tieghem causing collar rot in groundnut (Arachis hypogaea L.).

    abstract：:The study was conducted to examine the antioxidant enzymes induced by Trichoderma viride JAU60 as initial defense response during invasion of rot pathogen Aspergillus niger Van Tieghem in five groundnut varieties under pot culture. Seed treatment of T. viride JAU60 reduced 51-58% collar rot disease incidence in differ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2015.11.010

    authors： Gajera HP,Katakpara ZA,Patel SV,Golakiya BA

    更新日期：2016-02-01 00:00:00

  • Transcriptional regulation of Yersinia pestis biofilm formation.

    abstract：:Yersinia pestis, the causative agent of plague, is transmitted primarily by infected fleas in nature. Y. pestis can produce biofilms that block flea's proventriculus and promote flea-borne transmission. Transcriptional regulation of Y. pestis biofilm formation plays an important role in the response to complex changes...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2019.04.011

    authors： Liu L,Zheng S

    更新日期：2019-06-01 00:00:00

  • Assessment of adhesion, invasion and cytotoxicity potential of oral Staphylococcus aureus strains.

    abstract：:The oral cavity is regarded as a relevant site for Staphylococcus aureus colonization. However, characterization of virulence mechanisms of oral S. aureus remains to be uncovered. In this study, twenty one S. aureus strains isolated from the oral cavity of Tunisian patients were screened for adherence, invasion and cy...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2015.05.010

    authors： Merghni A,Ben Nejma M,Helali I,Hentati H,Bongiovanni A,Lafont F,Aouni M,Mastouri M

    更新日期：2015-09-01 00:00:00

  • Bacterial phenotypes mediated by mviA and their relationship to the mouse virulence of Salmonella typhimurium.

    abstract：:The focus of this study was the phenotypic characterization of Salmonella typhimurium mutants lacking the function of the response regulator mviA. The inactivation of mviA+ (mviA::kan) is shown to induce a significant change in the growth of most virulent strains, as reflected in the size of the colonies formed on aga...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1996.0117

    authors： Swords WE,Giddings A,Benjamin WH Jr

    更新日期：1997-06-01 00:00:00

  • Sub-inhibitory concentrations of fluoroquinolones increase conjugation frequency.

    abstract：:Bacteria are subjected to sub-minimal inhibitory concentrations (sub-MIC) of antibiotics in various niches where the low-dosage treatment plays a key role in antibiotic resistance selection. However, the mechanism of sub-MIC of antibiotics on the resistant gene transfer is largely unknown. Here, we used Escherichia co...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.11.036

    authors： Shun-Mei E,Zeng JM,Yuan H,Lu Y,Cai RX,Chen C

    更新日期：2018-01-01 00:00:00

  • Glycobiology of the oral pathogen Porphyromonas gingivalis and related species.

    abstract：:Until recently, glycoproteins had only been described in eukaryotes. However, advances in detection methods and genome analyses have allowed the discovery of N-linked or O-linked glycoproteins, similar to those found in eukaryotes, in some bacterial species. These prokaryotic glycoproteins play roles in adhesion, solu...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2015.09.012

    authors： Shoji M,Nakayama K

    更新日期：2016-05-01 00:00:00

  • Expression and mutagenesis of recombinant cholera toxin A subunit.

    abstract：:ADP-ribosylating protein exotoxins from Vibrio cholerae (CT) and Escherichia coli (LT-I) share two short regions of sequence similarity with Bordetella pertussis toxin (PT). Previous studies have indicated that substitution of arginine for lysine 7 within the first region of CT drastically decreases ADP ribosyltransfe...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1994.1079

    authors： Vadheim KL,Singh Y,Keith JM

    更新日期：1994-11-01 00:00:00

  • Genetic diversity and virulence characteristics of Staphylococcus aureus isolates from cases of bovine mastitis.

    abstract：:Staphylococcus aureus is one of the major bacterial mastitis pathogens with significant effects on animal and human health. Some studies showed that S. aureus strains that infect different host species are genetically distinct, although most strains can infect a wide range of host species. However, there are no clearl...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104171

    authors： Vaughn JM,Abdi RD,Gillespie BE,Kerro Dego O

    更新日期：2020-07-01 00:00:00

  • Clinical and serological approach to patients with brucellosis: A common diagnostic dilemma and a worldwide perspective.

    abstract：:According to the WHO factsheet, although approximately half a million brucellosis cases are reported annually, the true incidence is always 10-25 times higher than the reported number of cases. Therefore, we face a common yet uncommonly recognized entity of brucellosis, which highlights the importance of providing pre...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2019.02.011

    authors： Avijgan M,Rostamnezhad M,Jahanbani-Ardakani H

    更新日期：2019-04-01 00:00:00

  • Use of confocal microscopy to detect Salmonella typhimurium within host cells associated with Spv-mediated intracellular proliferation.

    abstract：:The major limitation in histological examination of orally inoculated mice of Salmonella typhimurium has been the difficulty of attaining high enough levels for immunochemical detection. This problem has been solved by the use of confocal laser scanning microscopy (CLSM) analysis, which allows detection of bacteria in...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0370

    authors： Matsui H,Eguchi M,Kikuchi Y

    更新日期：2000-07-01 00:00:00

  • Role of bacterial Ser/Thr protein kinases spr 1577 in the pathogenesis of respiratory infections caused by S. pneumoniae.

    abstract：:This study investigated the specific role played by conserved membrane eukaryotic-like Ser/Thr protein kinases (StkP) during infection, particularly pneumonia, in order to get deep insights about Ser/Thr protein kinases signaling during infection and pathogenesis. The wild type and mutated Ser/Thr protein kinases (Spr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104065

    authors： Sun Y,Aljeldah MM,Wang S

    更新日期：2020-02-14 00:00:00

  • Identification of a maltose-inducible major outer membrane protein in Actinobacillus (Haemophilus) pleuropneumoniae.

    abstract：:The addition of maltose to the growth media of Actinobacillus pleuropneumonia (serotype 1) resulted in the induction of an outer membrane protein (OMP) with a molecular mass of 42 kDa. This protein had porin-like properties in that it was peptidoglycan-associated and was resistant to proteolysis by trypsin. A pleuropn...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(89)90084-3

    authors： Deneer HG,Potter AA

    更新日期：1989-06-01 00:00:00