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Interplay between MgtC and PagC in Salmonella enterica serovar Typhimurium.

Abstract：

:In Salmonella enterica serovar Typhimurium, MgtC and PagC are positively regulated by the PhoP-PhoQ two-component system, which is activated under magnesium deprivation. Both MgtC and PagC are of unknown function but have been involved in intramacrophage survival. We have found that the amount of PagC is lowered in a DeltamgtC mutant strain grown in magnesium depleted medium. However, the effect of MgtC on PagC does not account for the growth defect of a DeltamgtC mutant in macrophages since, in contrast to previous reports, our results indicate that PagC does not contribute to intramacrophage survival. In addition, a pagC null mutant is only poorly attenuated in Nramp1-negative or Nramp1-positive mice. On the other hand, a mgtC null mutant is significantly more attenuated with Nramp1-positive than Nramp1-negative mice, suggesting that a functional Nramp1 (Slc11a1) further limits the multiplication of this mutant within the host.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Alix E,Miki T,Felix C,Rang C,Figueroa-Bossi N,Demettre E,Blanc-Potard AB

doi

10.1016/j.micpath.2008.06.001

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

236-40

issue

3

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(08)00083-1

journal_volume

45

pub_type

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