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Geniposide reduces Staphylococcus aureus internalization into bovine mammary epithelial cells by inhibiting NF-κB activation.

Abstract：

:Staphylococcus aureus (S.aureus), a Gram-positive organism, is a frequent cause of subclinical mastitis. Geniposide, an iridoid glucoside isolated from the fruits of Gardenia jasminoides, has been reported to exhibit antibacterial and anti-inflammatory properties. The ability of S. aureus internalizing into bovine mammary epithelial cells (bMEC) has been responsible for the establishment of the bovine mastitis. In this study, we evaluated the effect of geniposide on S. aureus internalization into bMEC and investigated the possible mechanism of action. The results revealed that geniposide (25-100 μg/ml) reduced S. aureus internalization by 17%-67% and down-regulated the mRNA expressions of TAP and BNBD5. Furthermore, geniposide inhibited S.aureus-induced NF-κB activation in a dose-dependent manner. In summary, the potential mechanism of geniposide reducing S. aureus internalization may be by inhibiting NF-κB activation.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Wei Z,Su K,Jiang P,Shi M,Wang J,Xie G

doi

10.1016/j.micpath.2018.10.002

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

443-447

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(17)30244-9

journal_volume

125

pub_type

杂志文章

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