Abstract:
:The aim of present work was to investigate preventive role of orally administered Aloe vera supplemented probiotic lassi (APL) on Shigella dysenteriae infection in mice. At the end of experimental period (2, 5 and 7 days of challenging), different organs such as spleen, liver, small intestine, large intestine, and peritoneal fluid were collected and assessed for Shigella colonization. Secretary IgA was estimated in intestinal fluid. Blood was collected in heparinized tubes for various haematological studies. Oral administration of APL showed a significant (p < 0.05) reduction in the Shigella counts (log cfu/mL) in all organs as compared to other treatment groups at different intervals after post feeding. Similarly, secretary IgA antibody levels (μg/mL) in intestinal fluid were significantly (p < 0.05) increased in case of APL fed mice. Further, feeding of APL also demonstrated a positive effect on different haematological parameters viz. Hb (gm %), RBC and WBC count. The results indicated the immunoprotective effects of APL against Shigella dysenteriae induced infection in mice.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Hussain SA,Patil GR,Reddi S,Yadav V,Pothuraju R,Singh RRB,Kapila Sdoi
10.1016/j.micpath.2016.11.023subject
Has Abstractpub_date
2017-01-01 00:00:00pages
143-147eissn
0882-4010issn
1096-1208pii
S0882-4010(16)30692-1journal_volume
102pub_type
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