Aloe vera (Aloe barbadensis Miller) supplemented probiotic lassi prevents Shigella infiltration from epithelial barrier into systemic blood flow in mice model.

Abstract:

:The aim of present work was to investigate preventive role of orally administered Aloe vera supplemented probiotic lassi (APL) on Shigella dysenteriae infection in mice. At the end of experimental period (2, 5 and 7 days of challenging), different organs such as spleen, liver, small intestine, large intestine, and peritoneal fluid were collected and assessed for Shigella colonization. Secretary IgA was estimated in intestinal fluid. Blood was collected in heparinized tubes for various haematological studies. Oral administration of APL showed a significant (p < 0.05) reduction in the Shigella counts (log cfu/mL) in all organs as compared to other treatment groups at different intervals after post feeding. Similarly, secretary IgA antibody levels (μg/mL) in intestinal fluid were significantly (p < 0.05) increased in case of APL fed mice. Further, feeding of APL also demonstrated a positive effect on different haematological parameters viz. Hb (gm %), RBC and WBC count. The results indicated the immunoprotective effects of APL against Shigella dysenteriae induced infection in mice.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Hussain SA,Patil GR,Reddi S,Yadav V,Pothuraju R,Singh RRB,Kapila S

doi

10.1016/j.micpath.2016.11.023

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

143-147

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(16)30692-1

journal_volume

102

pub_type

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