Transcriptional analysis reveals the relativity of acid tolerance and antimicrobial peptide resistance of Salmonella.

Abstract:

:The objective of this study was to comprehensively identify the target genes induced by acid stimulation in Salmonella, and to clarify the relativity of acid tolerance and antimicrobial peptide resistance. A clinical S. Typhimurium strain, S6, was selected and performed a transcriptome analysis under the acid tolerance response. In total, we found 1461 genes to be differentially expressed, including 721 up-regulated and 740 down-regulated genes. Functional annotation revealed differentially expressed genes to be associated with regulation, metabolism, transport, virulence, and motility. Interestingly, KEGG pathway analysis demonstrated that the induced genes by acid were enriched in cationic antimicrobial peptide resistance, sulfur relay system, ABC transporters, and two-component system pathway. Therein, PhoQ belonging to the two-component system PhoP-PhoQ that promotes virulence by detecting the macrophage phagosome and controls the transcript levels of many genes associated with the resistance to AMPs; MarA, a multiple antibiotic resistance factor; SapA, one of the encoding gene of sapABCDF operon that confers resistance to small cationic peptides of Salmonella; YejB, one of the encoding gene of yejABEF operon that confers resistance to antimicrobial peptides and contributes to the virulence of Salmonella, were all induced by acid stimulation, and could potentially explain that there is a correlation between acid tolerance and AMPs resistance, and finally affects the virulence of intracellular pathogenic bacteria.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Cao L,Wang J,Sun L,Kong Z,Wu Q,Wang Z

doi

10.1016/j.micpath.2019.103701

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

103701

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(18)31751-0

journal_volume

136

pub_type

杂志文章
  • The global prevalence and risk factors of Toxoplasma gondii among foxes: A systematic review and meta-analysis.

    abstract::Toxoplasma gondii is one of the most successful intracellular protozoan parasites in the world, which can infect most warm-blooded animals including foxes in the world and cause toxoplasmosis. This is the first meta-analysis to assess the overall prevalence and potential risk factors of T. gondii among foxes in the wo...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2020.104699

    authors: Wei XY,Gao Y,Lv C,Wang W,Chen Y,Zhao Q,Gong QL,Zhang XX

    更新日期:2020-12-28 00:00:00

  • Hepatitis E virus seroprevalence rate among Eastern Mediterranean and middle eastern countries; A systematic review and pooled analysis.

    abstract:CONTEXT:Hepatitis E virus (HEV) as a hepatotropic virus is one of the major global health concerns. Autochthonous HEV transmitted by oral fecal-route in poor sanitation conditions as well as vertical and rarely blood transfusion. HEV occurrence is more common in developing countries and recently increased in developed ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章,评审

    doi:10.1016/j.micpath.2017.06.045

    authors: Karbalaie Niya MH,Rezaee-Zavareh MS,Ranaei A,Alavian SM

    更新日期:2017-09-01 00:00:00

  • The novel heat-stable enterotoxin subtype gene (ystB) of Yersinia enterocolitica: nucleotide sequence and distribution of the yst genes.

    abstract::The gene (ystB) encoding the novel subtype of the heat-stable enterotoxin (Y-STb) was cloned from the chromosome of a clinical isolate of Yersinia enterocolitica 84-50 (serotype O:5, biotype 1A) and the nucleotide sequence was determined. The ystB contained 216 base pairs that encoded a protein of 71 amino acid residu...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1006/mpat.1997.0146

    authors: Ramamurthy T,Yoshino Ki,Huang X,Balakrish Nair G,Carniel E,Maruyama T,Fukushima H,Takeda T

    更新日期:1997-10-01 00:00:00

  • Evaluating the anti-biofilm and antibacterial effects of Juglans regia L. extracts against clinical isolates of Pseudomonas aeruginosa.

    abstract:OBJECTIVE:Pseudomonas aeruginosa, an opportunistic pathogen, can cause serious health problems and produces several virulence factors. The most important of these factors is biofilm. Many studies suggest administration of new generation of antibiotics, as P. aeruginosa biofilm has developed high resistance to antimicro...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2018.03.055

    authors: Dolatabadi S,Moghadam HN,Mahdavi-Ourtakand M

    更新日期:2018-05-01 00:00:00

  • The multi-faceted potential of plant-derived metabolites as antimicrobial agents against multidrug-resistant pathogens.

    abstract::Multidrug-resistant (MDR) pathogens are currently causing serious problems globally in the medical setting. Improper and extensive usage of antibiotics results in a selective pressure supporting the rise of antibiotic-resistant microbes. Many key cellular bacterial components, including enzymes and small noncoding RNA...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章,评审

    doi:10.1016/j.micpath.2018.01.043

    authors: Shin J,Prabhakaran VS,Kim KS

    更新日期:2018-03-01 00:00:00

  • Immunization with the ferric iron-binding periplasmic protein HitA provides protection against Pseudomonas aeruginosa in the murine infection model.

    abstract::Pseudomonas aeruginosa is a notorious pathogen with increasing multi-drug resistance. This situation makes it urgent to develop a prophylactic vaccine against this pathogen. Different virulence factors play a crucial role in P. aeruginosa infection. This study focused on evaluation of the iron acquisition protein HitA...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2019.04.014

    authors: Elhosary MA,Bahey-El-Din M,AbdelBary A,El Guink N,Aboushleib HM

    更新日期:2019-06-01 00:00:00

  • Dexamethasone along with ciprofloxacin modulates S. aureus induced microglial inflammation via glucocorticoid (GC)-GC receptor-mediated pathway.

    abstract::Microglial inflammation is the hallmark of S. aureus induced brain abscesses. Conventional antibiotic therapy could not regulate inflammation and the use of steroids in CNS infection remained controversial. To address this issue the effect of dexamethasone along with ciprofloxacin on microglial inflammation has been a...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2020.104227

    authors: Dey R,Bishayi B

    更新日期:2020-08-01 00:00:00

  • Probiotic Lactobacillus fermentum KU200060 isolated from watery kimchi and its application in probiotic yogurt for oral health.

    abstract::Lactobacillus fermentum KU200060 was isolated from watery kimchi and its probiotic characteristics were evaluated, including tolerance to artificial gastric acid and bile salt, production of enzymes, ability to adhere to HT-29 cells, and antibiotic susceptibility. The antibacterial and antibiofilm effects of L. fermen...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2020.104430

    authors: Lim SM,Lee NK,Kim KT,Paik HD

    更新日期:2020-10-01 00:00:00

  • Biofilm inhibitory effect of chlorhexidine conjugated gold nanoparticles against Klebsiella pneumoniae.

    abstract::Klebsiella pneumoniae (K. pneumoniae) is one of the major pathogen associated with nosocomial infections, especially catheter associated urinary tract infections which involved biofilm formation. This study was designed to evaluate the antibiofilm efficacy of gold nanoparticle conjugated with chlorhexidine (Au-CHX) ag...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2016.06.016

    authors: Ahmed A,Khan AK,Anwar A,Ali SA,Shah MR

    更新日期:2016-09-01 00:00:00

  • Quercetin inhibits Pseudomonas aeruginosa biofilm formation via the vfr-mediated lasIR system.

    abstract::Pseudomonas aeruginosa is one of the most common opportunistic pathogens that cause biofilm-associated infections. Biofilm formation is partially regulated by the quorum sensing (QS) system, and quercetin can inhibit QS, biofilm formation and virulence factors. We therefore speculated that quercetin would inhibit the ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2020.104291

    authors: Ouyang J,Feng W,Lai X,Chen Y,Zhang X,Rong L,Sun F,Chen Y

    更新日期:2020-12-01 00:00:00

  • DNA from virulent M. tuberculosis induces TNF-α production and autophagy in M1 polarized macrophages.

    abstract::The macrophage innate immune response is outlined through recognition of the components of Mycobacterium tuberculosis. DNA of M. tuberculosis (MtbDNA) is recognized by macrophages, but the implications of this recognition are poorly characterized. Stimulation of murine macrophages with MtbDNA induces autophagy, a proc...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2019.04.041

    authors: Ruiz A,Guzmán-Beltrán S,Carreto-Binaghi LE,Gonzalez Y,Juárez E

    更新日期:2019-07-01 00:00:00

  • Antimicrobial and antibiofilm activity of the benzoquinone oncocalyxone A.

    abstract::Resistance to antimicrobials is a challenging issue that complicates the treatment of infections caused by bacteria and fungi, thus requiring new therapeutic options. Oncocalyxone A, a benzoquinone obtained from Auxemma oncocalyx (Allem) Taub has several biological effects; however, there is no data on its antimicrobi...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2020.104513

    authors: da Silva RE,Ribeiro FOS,de Carvalho AMA,Daboit TC,Marinho-Filho JDB,Matos TS,Pessoa ODL,de Souza de Almeida Leite JR,de Araújo AR,Dos Santos Soares MJ

    更新日期:2020-12-01 00:00:00

  • Bacterial phenotypes mediated by mviA and their relationship to the mouse virulence of Salmonella typhimurium.

    abstract::The focus of this study was the phenotypic characterization of Salmonella typhimurium mutants lacking the function of the response regulator mviA. The inactivation of mviA+ (mviA::kan) is shown to induce a significant change in the growth of most virulent strains, as reflected in the size of the colonies formed on aga...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1006/mpat.1996.0117

    authors: Swords WE,Giddings A,Benjamin WH Jr

    更新日期:1997-06-01 00:00:00

  • Deletions of chromosomal regions coding for fimbriae and hemolysins occur in vitro and in vivo in various extraintestinal Escherichia coli isolates.

    abstract::Fimbrial adhesins and hemolysins contribute to pathogenicity of extraintestinal Escherichia coli isolates causing urinary tract infections (UTI), sepsis and new born meningitis (NBM). Using gene cloning techniques and pulse field electrophoresis in combination with Southern hybridizations it was demonstrated that the ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/0882-4010(90)90048-u

    authors: Hacker J,Bender L,Ott M,Wingender J,Lund B,Marre R,Goebel W

    更新日期:1990-03-01 00:00:00

  • Amphotericin B-conjugated biogenic silver nanoparticles as an innovative strategy for fungal infections.

    abstract::New strategies are required to improve the efficacy of drugs and to treat the emerging microbial resistance. An effective strategy is to combine drugs with metal nanoparticles for the control of microbial infections and resistance. Keeping in view this fact, we developed a facile and eco-friendly protocol for the synt...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2016.08.031

    authors: Ahmad A,Wei Y,Syed F,Tahir K,Taj R,Khan AU,Hameed MU,Yuan Q

    更新日期:2016-10-01 00:00:00

  • Disperse red 15 (DR15) impedes biofilm formation of uropathogenic Escherichia coli.

    abstract::Catheter associated urinary tract infection (CAUTI) is a highly prevalent hospital-acquired infection that is predominantly caused by uropathogenic Escherichia coli (UPEC). It adheres on catheter surface using type I pili as the initial step of pathogenesis that progresses to form biofilm. In this study, potential inh...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2019.103772

    authors: Miryala S,Makala H,Yadavali SP,Venkatasubramanian U,Subbaiah N,Srinandan CS

    更新日期:2020-01-01 00:00:00

  • The Aeromonas dsbA mutation decreased their virulence by triggering type III secretion system but not flagella production.

    abstract::Pathogenesis of Aeromonas species have been reported to be associated with virulence factors such as lipopolysaccharides (LPS), bacterial toxins, bacterial secretion systems, flagella, and other surface molecules. Dsb (Disulfide bond) proteins play an important role in catalyzing disulfide bond formation in proteins w...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2011.10.006

    authors: Vilches S,Jiménez N,Merino S,Tomás JM

    更新日期:2012-02-01 00:00:00

  • Stable isotope labelling by amino acids in cell culture (SILAC) applied to quantitative proteomics of Edwardsiella tarda ATCC 15947 under prolonged cold stress.

    abstract::Edwardsiella tarda poses a threat to human health and has resulted in enormous economic losses in aquaculture. Low temperatures are usually applied to contain the growth of this microorganism. In this study, stable isotope labelling by amino acids in cell culture (SILAC) was used to conduct comparative proteomic quant...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2018.09.006

    authors: Ma W,Jia J,Huang X,Xie W,Zhang X,Tang J,Lin C,Zhao L,Fang P

    更新日期:2018-12-01 00:00:00

  • Reactivity of Haemophilus influenzae type b anti-pili antibodies.

    abstract::The reactivity of anti-pilus antibodies to native and denatured Haemophilus influenzae b (Hib) pili was studied using rabbit serum prepared against piliated H. influenzae b strain M43 (p+) and adsorbed with its non-piliated variant, strain M42 (p-). The specificity of the adsorbed serum for Hib pili was documented by ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/0882-4010(89)90049-1

    authors: Gilsdorf JR,Forney LJ,LiPuma JJ

    更新日期:1989-10-01 00:00:00

  • Potentiation of antibiotic activity of aminoglycosides by natural products from Cordia verbenacea DC.

    abstract::Medicinal plants are often the only therapeutic resource for many communities and ethnic groups. Cordia verbenacea DC., "Erva-baleeira," is one of the species of plants currently used to produce a phytotherapeutic product extracted from its leaves. The present study aimed to establish its chemical profile, antibacteri...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2016.03.009

    authors: Matias EFF,Alves EF,Silva MKN,Carvalho VRA,Medeiros CR,Santos FAV,Bitu VCN,Souza CES,Figueredo FG,Boligon AA,Athayde ML,Costa JGM,Coutinho HDM

    更新日期:2016-06-01 00:00:00

  • A 26 kDa protein of helicobacter pylori shows alkyl hydroperoxide reductase (AhpC) activity and the mono-cistronic transcription of the gene is affected by pH.

    abstract::The 26 kDa protein of Helicobacter pylori, with 67% amino acid identity to alkyl hydroperoxide reductase (AhpC) of Campylobacter jejuni, was studied. We wanted to evaluate it the protein has AhpC activity. Therefore, an Escherichia coli mutant defective for alkyl hydroperoxide reductase and a plasmid expressing the 26...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1006/mpat.2000.0388

    authors: Lundström AM,Bölin I

    更新日期:2000-11-01 00:00:00

  • Zero valent silver nanoparticles capped with capsaicinoids containing Capsicum annuum extract, exert potent anti-biofilm effect on food borne pathogen Staphylococcus aureus and curtail planktonic growth on a zebrafish infection model.

    abstract::Food plants Hungarian wax pepper (HWP) and Green Bell pepper (GBP), belonging to Capsicum annuum were utilized for biogenic fabrication of zero valent, nano-silver (AgNPs) through a photo-mediation procedure. In the bacterial strains evaluated, HWP/GBP AgNPs demonstrated effective bacteriostatic and bactericidal effec...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2018.08.053

    authors: Lotha R,Shamprasad BR,Sundaramoorthy NS,Ganapathy R,Nagarajan S,Sivasubramanian A

    更新日期:2018-11-01 00:00:00

  • Principle component analysis (PCA) for investigation of relationship between population dynamics of microbial pathogenesis, chemical and sensory characteristics in beef slices containing Tarragon essential oil.

    abstract::Principle component analysis (PCA) was employed to examine the effect of the exerted treatments on the beef shelf life as well as discovering the correlations between the studied responses. Considering the variability of the dimensions of the responses, correlation coefficients were applied to form the matrix and extr...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2017.02.013

    authors: Alizadeh Behbahani B,Tabatabaei Yazdi F,Shahidi F,Mortazavi SA,Mohebbi M

    更新日期:2017-04-01 00:00:00

  • The cold shock family gene cspD3 is involved in the pathogenicity of Ralstonia solanacearum CQPS-1 to tobacco.

    abstract::Cold shock proteins (Csps) are small and highly conserved proteins that have target RNA- and DNA-binding activities. Csps play roles in different cellular processes and show functional redundancy. Ralstonia solanacearum, the agent of bacterial wilt, has 4 or 5 Csps based on genome analysis. However, the functions of a...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2020.104091

    authors: Liu Y,Tan X,Cheng H,Gong J,Zhang Y,Wang D,Ding W

    更新日期:2020-02-20 00:00:00

  • An endophytic strain JK of genus bacillus isolated from the seeds of super hybrid rice (Oryza sativa L., Shenliangyou 5814) has antagonistic activity against rice blast pathogen.

    abstract::Rice is an important food crop in the world, and rice blast is one of the major fungal diseases that cause large-scale rice yield reduction. This study aimed to investigate the antagonistic activity and its molecular mechanism of bacterial strain JK isolated from seeds of super hybrid rice 'Shenliangyou 5814' (Oryza s...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2020.104422

    authors: Jing R,Li N,Wang W,Liu Y

    更新日期:2020-10-01 00:00:00

  • Complete genome sequence of Bacillus licheniformis BL-010.

    abstract::The biodegradation of Aflatoxin B1 (AFB1) is an industry of increasing importance. Bacillus licheniformis BL-010 was isolated from the aflatoxin contaminated corn feed storage, and was shown to degrade AFB1 efficiently. Here we present the complete genome sequence of BL-010, the genome comprises 4,287,714 bp in a circ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2018.03.037

    authors: He S,Feng K,Ding T,Huang K,Yan H,Liu X,Zhang Z

    更新日期:2018-05-01 00:00:00

  • Antibacterial activity of the bioactive compounds identified in three woody plants against some pathogenic bacteria.

    abstract::Three bacterial isolates were identified from infected potato tubers showing soft and blackleg like symptoms as well as one isolate from infected pear tree showing crown gall symptom. Conventional and molecular identification proved that bacterial isolates belonging to Pectobacterium carotovorum subsp. carotovorum, Pe...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2018.05.032

    authors: Ashmawy NA,Salem MZM,El-Hefny M,Abd El-Kareem MSM,El-Shanhorey NA,Mohamed AA,Salem AZM

    更新日期:2018-08-01 00:00:00

  • Macrophage--Mycobacterium tuberculosis interactions: role of complement receptor 3.

    abstract::Tuberculosis is the leading infectious disease in the world. Mycobacterium tuberculosis, the causal agent of this disease, invades macrophages and can replicate inside them. Because invasion of macrophages is a critical step for establishing a mycobacterial infection, there is much interest in understanding the mechan...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章,评审

    doi:10.1016/s0882-4010(03)00099-8

    authors: Velasco-Velázquez MA,Barrera D,González-Arenas A,Rosales C,Agramonte-Hevia J

    更新日期:2003-09-01 00:00:00

  • Comprehensive analysis of the phylogeny and extracellular proteases in genus Vibrio strain.

    abstract::As one of the dominant bacteria in the ocean, Vibrio play important roles in maintaining the aquatic ecosystem. In this study, we studied the phylogenetic relationships of 32 Vibrio based on the 16S rRNA genes sequences and utilized substrate immersing zymography method to detect the trend of protease production and c...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1016/j.micpath.2019.03.018

    authors: Liu D,Wu C,Wu R,Huang J,Liao B,Lei M,Zhang Y,He H

    更新日期:2019-06-01 00:00:00

  • Nucleotide sequence variations within the lipopolysaccharide biosynthesis gene gseA (Kdo transferase) among the Chlamydia trachomatis serovars.

    abstract::The gene gseA, involved in the expression of the genus-specific epitope of chlamydial lipopolysaccharide (LPS), was analyzed by temperature gradient gel electrophoresis (TGGE) to visualize nucleotide sequence variations among the 15 serovars of Chlamydia trachomatis. Sequence analysis showed that the TGGE melting-prof...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章

    doi:10.1006/mpat.1994.1055

    authors: Mamat U,Löbau S,Persson K,Brade H

    更新日期:1994-08-01 00:00:00