Protective immunity induced by a DNA vaccine cocktail expressing TgSAG1, TgROP2, and the genetic adjuvant HBsAg against Toxoplasma gondii infection.

abstract：:Little is known about the virulence factors of Burkholderia mallei, the etiologic agent of glanders. We employed subtractive hybridization to identify genetic determinants present in B. mallei but not in Burkholderia thailandensis, a non-pathogenic soil microbe. Three subtractive hybridization products were mapped to ...

journal_title：Microbial pathogenesis

authors： DeShazer D,Waag DM,Fritz DL,Woods DE

更新日期：2001-05-01 00:00:00

abstract：:Bacillus anthracis secretes three major components, which assemble into two bipartite toxins: lethal toxin (LT), composed of lethal factor (LF) and protective antigen (PA) and edema toxin (ET), composed of edema factor (EF) and PA. EF is a potent calmodulin-dependent adenylate cyclase, which is internalized into the t...

journal_title：Microbial pathogenesis

authors： Levy H,Weiss S,Altboum Z,Schlomovitz J,Rothschild N,Glinert I,Sittner A,Kobiler D

更新日期：2012-01-01 00:00:00

abstract：:Brucellosis, a disease caused by the gram-negative bacterium Brucella spp., is a widespread zoonosis that inflicts important animal and human health problems, especially in developing countries. One of the hallmarks of Brucella infection is its capacity to establish a chronic infection, characteristic that depends on ...

journal_title：Microbial pathogenesis

authors： Spera JM,Comerci DJ,Ugalde JE

更新日期：2014-02-01 00:00:00

abstract：:Ehrlichia risticii, the causative agent of Potomac horse fever, is an obligate intracellular rickettsial organism. To understand the role of 55 and 51 kilodalton immunodominant antigens of E. risticii in strain variation, their genes from the 25-D and 90-12 strains were cloned, sequenced, and expressed in E. coli. Seq...

journal_title：Microbial pathogenesis

authors： Vemulapalli R,Biswas B,Dutta SK

更新日期：1998-06-01 00:00:00

abstract：:Group B streptococci (GBS) are opportunistic human pathogens that cause infection and invasive disease in newborns, pregnant women and non-pregnant adults. The internalization of GBS into eukaryotic cells occurs in an actin-microfilament dependent process. The objective of our study was to understand what host cell an...

journal_title：Microbial pathogenesis

authors： Burnham CA,Shokoples SE,Tyrrell GJ

更新日期：2005-05-01 00:00:00

abstract：:Capnocytophaga canimorsus is a part of healthy oral flora of dogs and cats. However, when it is transmitted to human subjects via animal bites or scratches, it can cause severe complications like endocarditis or even lethal septic shock, especially in immunocompromised persons. In this study, we performed the first wh...

journal_title：Microbial pathogenesis

authors： Shelenkov AA,Karan LS,Mihaylova YV,Yanushevich YG,Shipulin GA,Shagin DA

更新日期：2018-12-01 00:00:00

abstract：:In mice, nitric oxide (NO) production by inducible NO synthase (iNOS), is a component of the control of Brucella infection. In humans, the involvement of iNOS in infection is still a matter of debate. Based on in vitro experiments, it was recently postulated that in humans, Brucella infection tends to become chronic b...

journal_title：Microbial pathogenesis

authors： Gross A,Bertholet S,Mauel J,Dornand J

更新日期：2004-02-01 00:00:00

abstract：:Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus which is histopathologically characterized by inflammatory manifestations, indicating that rickettsiae induce mechanisms that amplify the inflammatory response. To understand the pathogenesis of scrub typhus, we examine...

journal_title：Microbial pathogenesis

authors： Koh YS,Yun JH,Seong SY,Choi MS,Kim IS

更新日期：2004-01-01 00:00:00

abstract：:HPV persistent infection is a main event leading to the development of cervical intraepithelial neoplasia and cervical cancer. Earlier to distinguish HPV persistent and transient infection is meaningful but the methods are limited. This study used 16S rDNA sequencing to determine the cervicovaginal microbiota of HPV p...

journal_title：Microbial pathogenesis

authors： Qingqing B,Jie Z,Songben Q,Juan C,Lei Z,Mu X

更新日期：2020-11-15 00:00:00

abstract：:It has been shown that N-linked high mannose type oligosaccharides competitively inhibits attachment to and infectivity of chlamydiae in HeLa cells. To further study whether mannose moieties are involved in the infectivity of chlamydiae, the susceptibility of mannose-receptor negative J774A and positive J774E mouse ma...

journal_title：Microbial pathogenesis

authors： Kuo CC,Puolakkainen M,Lin TM,Witte M,Campbell LA

更新日期：2002-01-01 00:00:00

abstract：:Quorum sensing (QS), a cell-to-cell communication mechanism present in many bacterial species plays a key role in regulating the virulence factor and biofilm formation in many pathogens, which causes severe public health risk. Therefore, interfering with QS mechanism offers an attractive strategy to combat bacterial i...

journal_title：Microbial pathogenesis

authors： Vasavi HS,Sudeep HV,Lingaraju HB,Shyam Prasad K

更新日期：2017-03-01 00:00:00

abstract：:A recent study has described the normal vaginal bacterial community in giant pandas, but there is a lack of knowledge of the fungal community residing in the vagina of giant pandas. In order to comprehensively understand the vaginal fungal microbial diversity and abundance in giant pandas, high throughput sequencing w...

journal_title：Microbial pathogenesis

authors： Chen D,Li C,Feng L,Zhang Z,Zhang H,Cheng G,Li D,Zhang G,Wang H,Chen Y,Feng M,Wang C,Wu H,Deng L,Ming H,Yang X

更新日期：2018-02-01 00:00:00

abstract：:Enterotoxignenic Escherichia coli (ETEC)-associated colibacillosis causes high levels of morbidity and mortality in neonatal piglets. Vaccination is among effective strategy to fight against ETEC-related diseases. Bacterial ghosts (BGs) are empty bacterial envelopes, which substain subtle antigenic comformation in bac...

journal_title：Microbial pathogenesis

authors： Ran X,Chen X,Wang S,Chang C,Wen X,Zhai J,Ni H

更新日期：2019-01-01 00:00:00

abstract：:Recent studies based on sequence divergence in the ospC gene have identified limited subpopulations of B. burgdorferi associated with invasive human disease. Spirochetes with certain OspC types never cause human disease, while some others cause local infection at the primary skin site but do not hematogenously dissemi...

journal_title：Microbial pathogenesis

authors： Xu Y,Bruno JF,Luft BJ

更新日期：2003-12-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) strains from AIDS and non-AIDS patients and from the environment were studied for their colony morphology and virulence in beige mice. The majority of the MAC isolates from AIDS patients, in contrast to those from non-AIDS patients and the environment, showed increased virulence. Simi...

journal_title：Microbial pathogenesis

authors： Reddy VM,Parikh K,Luna-Herrera J,Falkinham JO 3rd,Brown S,Gangadharam PR

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:To determine the frequency of occurrence of Mycoplasma genitalium infection in the peritoneal fluid of infertile women as compared to fertile women. MATERIALS AND METHODS:We have selected 162 infertile women aged 22-40 years as study subject and 162 women posted for elective caesarean section, were taken as ...

journal_title：Microbial pathogenesis

authors： Rekha S,Nooren M,Kalyan S,Mohan M,Bharti M,Monika R,Anita S,Kiran M,Vandana N

更新日期：2019-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is a notorious pathogen with increasing multi-drug resistance. This situation makes it urgent to develop a prophylactic vaccine against this pathogen. Different virulence factors play a crucial role in P. aeruginosa infection. This study focused on evaluation of the iron acquisition protein HitA...

journal_title：Microbial pathogenesis

authors： Elhosary MA,Bahey-El-Din M,AbdelBary A,El Guink N,Aboushleib HM

更新日期：2019-06-01 00:00:00

abstract：:Elimination of pathogenic microorganisms in the liver may be an important effector mechanism in host defenses. In this paper we describe the adhesion, invasion and multiplication of Salmonella typhimurium in a murine embryonic hepatocyte cell line (ATCC TIB-73). Monolayers of hepatocytes treated with recombinant IFN g...

journal_title：Microbial pathogenesis

authors： Lajarin F,Rubio G,Galvez J,Garcia-Peñarrubia P

更新日期：1996-11-01 00:00:00

abstract：:BALB/c mice were infected with 10(5) colony forming units (cfu) of Mycobacterium avium TMC 702 i.v. and the growth of the inoculum followed in the spleens of control mice. Other infected mice given weekly doses of 1 microgram of TGF-b1 or weekly doses of 2 mg of a rabbit antiserum against mouse TGF-b1 were evaluated f...

journal_title：Microbial pathogenesis

authors： Denis M,Ghadirian E

更新日期：1991-11-01 00:00:00

abstract：:Bacterial extracellular vesicles (EVs) have come forth into notice as possible important agent to mediate host-pathogen interactions. In this scientific research, the authors have tried to find out the effect of EVs derived from Lactobacillus rhamnosus GG (LDEVs) on the apoptosis induction in HepG2 cell line. The EVs ...

journal_title：Microbial pathogenesis

authors： Behzadi E,Mahmoodzadeh Hosseini H,Imani Fooladi AA

更新日期：2017-09-01 00:00:00

abstract：:This study was designed to screen for SCCmec types and to characterize the attachment site (attB) and universal insertion site (orfX) of SCCmec in a collection of 27 isolates (n = 11) methicillin resistant S. aureus and (n = 16) methicillin susceptible S. aureus isolates in Malaysia. Screening of SCCmec types and char...

journal_title：Microbial pathogenesis

authors： Bitrus AA,Zunita Z,Khairani-Bejo S,Othman S,Ahmad Nadzir NA

更新日期：2018-10-01 00:00:00

abstract：:Acinetobacter baumannii potential to form biofilm and exhibit multiple antibiotic resistances may be responsible in its survival in hospital environment. Accordingly, our study was aimed to determine the correlation between ability of biofilm formation and the frequency of biofilm related genes with antibiotic resista...

journal_title：Microbial pathogenesis

authors： Bardbari AM,Arabestani MR,Karami M,Keramat F,Alikhani MY,Bagheri KP

更新日期：2017-07-01 00:00:00

abstract：:As an economic devastating virus, porcine reproductive and respiratory syndrome virus (PRRSV) has spread globally, and seriously hinders the healthy development of the swine industry worldwide. In recent years, however, recombinant PRRSV strains are continuously emerging, resulting in the death of a large number of pi...

journal_title：Microbial pathogenesis

authors： Song Z,Zhang Q,Chen Y,Shen H,Yang G,Jiang P,Chen JL,Lin L

更新日期：2020-12-01 00:00:00

abstract：:The high incidence of bacterial respiratory infections has led to a focus on evaluating the human respiratory microbiome. Studies based on culture-based and molecular methods have shown an increase in the bacterial community that includes the bacterial phyla Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteri...

journal_title：Microbial pathogenesis

authors： Maleki A,Zamirnasta M,Taherikalani M,Pakzad I,Mohammadi J,Krutova M,Kouhsari E,Sadeghifard N

更新日期：2020-06-01 00:00:00

abstract：:The clinical course of infection with Mycobacterium leprae varies widely and depends on the pattern of the host immune response. Dendritic cells play an important role in the activation of the innate and adaptive immune system and seem to be essential for the development of the disease. To analyze the presence of epid...

journal_title：Microbial pathogenesis

authors： Hirai KE,Aarão TL,Silva LM,de Sousa JR,de Souza J,Dias LB Jr,Carneiro FR,Fuzii HT,Quaresma JA

更新日期：2016-02-01 00:00:00

abstract：:We report the study of a predicted outer-membrane leptospiral protein encoded by the gene lic11207. This protein is conserved in several pathogenic leptospiral strains but is absent in the saprophyte Leptospira biflexa. This putative outer-membrane protein has a domain of unknown function (DUF) 1565 found in several p...

journal_title：Microbial pathogenesis

authors： Pretre G,Lapponi MJ,Atzingen MV,Schattner M,Nascimento AL,Gómez RM

更新日期：2013-03-01 00:00:00

abstract：:Phenotypic serum resistance of gonococci in urethral exudates is due to sialylation of lipopolysaccharide (LPS) by host cytidine 5'-monophospho-N-acetyl neuraminic acid (CMP-NANA). A surface structure was visible on gonococci [strain BS4 (agar)] that had been stained with ruthenium red after incubation with CMP-NANA. ...

journal_title：Microbial pathogenesis

authors： Fox AJ,Curry A,Jones DM,Demarco de Hormaeche R,Parsons NJ,Cole JA,Smith H

更新日期：1991-09-01 00:00:00

abstract：:Indole is a metabolite of tryptophan that can be synthesized by various bacteria. In the present study, production of indole by Vibrio splendidus Vs was determined using Kovac's reagent, and m/z was further determined by HPLC-MS. Extracellular indole reached a maximum concentration of 160 μM, when OD600 of V. splendid...

journal_title：Microbial pathogenesis

authors： Zhang S,Zhang W,Liu N,Song T,Liu H,Zhao X,Xu W,Li C

更新日期：2017-10-01 00:00:00

abstract：:In this paper, we have assessed the role of changing physicochemical parameters and substrate types on the production of α-amylase enzyme from Penicillium chrysogenum, with a view to determining the optimal conditions required for its maximum production. The findings of this research revealed that, at pH 6 using linse...

journal_title：Microbial pathogenesis

authors： Dar GH,Kamili AN,Nazir R,Bandh SA,Jan TR,Chishti MZ

更新日期：2015-11-01 00:00:00

abstract：:Mannheimia(Pasteurella)haemolytica serotype 1 is the primary causative agent responsible for bovine pneumonic mannheimiosis, also known as shipping fever in cattle. The bacterium produces a variety of virulence factors, foremost of which is the exotoxic leukotoxin. The leukotoxin is a calcium-dependent cytolysin that ...

journal_title：Microbial pathogenesis

authors： Thumbikat P,Briggs RE,Kannan MS,Maheswaran SK

更新日期：2003-05-01 00:00:00