Abstract：
:Brucellosis, a disease caused by the gram-negative bacterium Brucella spp., is a widespread zoonosis that inflicts important animal and human health problems, especially in developing countries. One of the hallmarks of Brucella infection is its capacity to establish a chronic infection, characteristic that depends on a wide repertoire of virulence factors among which are immunomodulatory proteins such as PrpA (encoding the proline racemase protein A or hydroxyproline-2-epimerase), involved in the establishment of the chronic phase of the infectious process that we have previously identified and characterized. We report here that, in vivo, Brucella abortus prpA is responsible for an increment in the B-cell number and in the specific antibody response and that these antibodies promote cell infection. We additionally found that Brucella alters the cytokine levels of IFN-γ, IL-10, TGFβ1 and TNFα during the acute phase of the infectious process in a prpA dependent manner.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Spera JM,Comerci DJ,Ugalde JEdoi
10.1016/j.micpath.2014.01.003subject
Has Abstractpub_date
2014-02-01 00:00:00pages
8-13eissn
0882-4010issn
1096-1208pii
S0882-4010(14)00007-2journal_volume
67-68pub_type
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
doi：10.1006/mpat.1996.0088
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pub_type： 杂志文章,meta分析
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abstract：:Peste des petits ruminants (PPR), an economically important viral transboundary disease of small ruminants is not only prevalent in Pakistan but also in other countries where people rely on agriculture and animal products. The present study was aimed at describing the pathology and antigen localization in natural PPR ...
journal_title：Microbial pathogenesis
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doi：10.1016/j.micpath.2018.02.009
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