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Frequency of virulence factors in Helicobacter pylori-infected patients with gastritis.

Abstract：

UNLABELLED:The outcome of Helicobacter pylori infection has been related to specific virulence-associated bacterial genotypes. The vacuolating cytotoxin (vacA), cagA gene, oipA and babA2 gene are important virulence factor involving gastric diseases. The objective of this study was to assess the relationship between virulence factors of H. pylori and histopathological findings. MATERIAL AND METHODS:Gastroduodenoscopy was performed in 436 dyspeptic patients. Antrum biopsy was obtained for detection of H. pylori, virulence factors and for histopathological assessment. The polymerase chain reaction was used to detect virulence factors of H. pylori using specific primers. RESULTS:vacA genotypes in patients infected with H. pylori were associated with cagA, iceA1 and iceA2. In the patients with H. pylori infection there was a significant relationship between cagA positivity and neutrophil activity (P = 0.004) and chronic inflammation (P = 0.013) and with H. pylori density (P = 0.034). Neutrophil infiltration was found to be more severe in the s1 group than in the s2 group (P = 0.042). Also was a significant relationship between oipA positivity and neutrophil activity (P = 0.004) and with H. pylori density (P = 0.018). No significant relationships were observed between other vacA genotypes and histopathological parameters. CONCLUSION:H. pylori strains showing cagA, vacA s1 and oipA positivity are associated with more severe gastritis in some histological features but virulence factors of H. pylori do not appear to determine the overall pattern of gastritis.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Salimzadeh L,Bagheri N,Zamanzad B,Azadegan-Dehkordi F,Rahimian G,Hashemzadeh-Chaleshtori M,Rafieian-Kopaei M,Sanei MH,Shirzad H

doi

10.1016/j.micpath.2015.01.008

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

67-72

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(15)00009-1

journal_volume

80

pub_type

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