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Immunopathogenesis of infection with the visceralizing Leishmania species.

Abstract：

:Human leishmaniasis is a spectral disease that includes asymptomatic self-resolving infection, localized skin lesions, and progressive visceral leishmaniasis. With some overlap, visceral and cutaneous leishmaniasis are usually caused by different species of Leishmania. This review focuses on host responses to infection with the species that cause visceral leishmaniasis, as they contrast with species causing localized cutaneous leishmaniasis. Data from experimental models document significant differences between host responses to organisms causing these diverse syndromes. The visceralizing Leishmania spp. cause localized organ-specific immune responses that are important determinants of disease outcome. Both the Leishmania species causing cutaneous and those causing visceral leishmaniasis require a Type 1 immune response to undergo cure in mouse models. However, during progressive murine infection with the visceralizing Leishmania sp., the Type 1 response is suppressed at least in part by TGF-beta and IL-10 without type 2 cytokine production. This contrasts with the cutaneous species L. major, in which a Type 2 response suppresses type 1 cytokines and leads to murine disease progression. Population and family studies are beginning to elucidate human genetic determinants predisposing to different outcomes of Leishmania infection. These studies should eventually result in a better understanding of the immunopathogenesis and the spectrum of human leishmaniasis.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Wilson ME,Jeronimo SM,Pearson RD

doi

10.1016/j.micpath.2004.11.002

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

147-60

issue

4

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(05)00007-0

journal_volume

38

pub_type

杂志文章,评审

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