当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > Increased monokines in cytomegalovirus infected myelomonocytic cell cultures.

Increased monokines in cytomegalovirus infected myelomonocytic cell cultures.

Abstract：

:In an investigation of the role of monokines in CMV associated immunosuppression we document modulation of both TNF and IL-1 beta in CMV infected THP-1 cells. CMV infected cultures released almost two-fold more IL-1 beta protein and contained significantly higher IL-1 beta mRNA levels than uninfected cultures for 72-96 h after induction. In both CMV infected and uninfected cultures, significant amounts of IL-1 beta protein were not detected until 24 h post induction, while maximum amounts of TNF were detected in culture supernatants by 3 h post induction, suggesting that TNF may play a role in IL-1 beta induction. TNF levels subsequently declined but in infected cultures remained over 2.5-fold higher than controls through 96 h. The CMV alteration in the kinetics and extent of IL-1 beta release must be indirectly mediated by CMV since only 1% of THP-1 cells were infected. Most infected cells expressed CMV immediate early proteins but did not overexpress IL-1. We speculate that CMV infected cells release excess TNF or other stimulatory factors which increase IL-1 beta synthesis. Since IL-1 beta is increased, the decreased IL-1 'activity' described by others as an explanation in part for the immunosuppressive effects of infection may actually reflect alterations of IL-1 inhibitor levels during CMV infection.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Turtinen LW,Assimacopoulos A,Haase AT

doi

10.1016/0882-4010(89)90032-6

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

135-45

issue

2

eissn

0882-4010

issn

1096-1208

pii

0882-4010(89)90032-6

journal_volume

7

pub_type

杂志文章

相关文献

MICROBIAL PATHOGENESIS文献大全
  • First whole genome sequencing of Russian isolate of Capnocytophaga canimorsus, opportunistic pathogen causing lethal sepsis.

    abstract：:Capnocytophaga canimorsus is a part of healthy oral flora of dogs and cats. However, when it is transmitted to human subjects via animal bites or scratches, it can cause severe complications like endocarditis or even lethal septic shock, especially in immunocompromised persons. In this study, we performed the first wh...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.10.020

    authors： Shelenkov AA,Karan LS,Mihaylova YV,Yanushevich YG,Shipulin GA,Shagin DA

    更新日期：2018-12-01 00:00:00

  • Structure, function and regulation of the thermostable direct hemolysin (TDH) in pandemic Vibrio parahaemolyticus.

    abstract：:Vibrio parahaemolyticus is a leading cause of seafood-associated bacterial gastroenteritis. The pathogen produces the thermostable direct hemolysin (TDH), which is the sole cause of the Kanagawa phenomenon (KP), a special β-type haemolysis in the Wagatsuma agar. TDH also exerts several other biological activities, the...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2018.07.021

    authors： Cai Q,Zhang Y

    更新日期：2018-10-01 00:00:00

  • Detection of genetic diversity in linear plasmids 28-3 and 36 in Borrelia burgdorferi sensu stricto isolates by subtractive hybridization.

    abstract：:Recent studies based on sequence divergence in the ospC gene have identified limited subpopulations of B. burgdorferi associated with invasive human disease. Spirochetes with certain OspC types never cause human disease, while some others cause local infection at the primary skin site but do not hematogenously dissemi...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/s0882-4010(03)00152-9

    authors： Xu Y,Bruno JF,Luft BJ

    更新日期：2003-12-01 00:00:00

  • The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells.

    abstract：:Invasion plasmid antigen C (IpaC) is secreted by the Shigella flexneri type III secretion system (TTSS) as an essential trigger of epithelial cell invasion. At the molecular level, IpaC possesses a distinct functional organization. The IpaC C-terminal region between amino acids 319 and 345 is predicted to form a coile...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2008.06.003

    authors： Terry CM,Picking WL,Birket SE,Flentie K,Hoffman BM,Barker JR,Picking WD

    更新日期：2008-10-01 00:00:00

  • Genetic analysis of the plasmid region controlling virulence in Yersinia enterocolitica 0:9 by Mini-Mu insertions and lac gene fusions.

    abstract：:Enteropathogenic strains of Yersinia enterocolitica harbor a virulence plasmid (pYVe plasmid) of 70 kilobases (kb) which specifies, at 37 degrees C, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of outer membrane proteins (OMP). Some m...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(86)90067-7

    authors： Cornelis G,Sory MP,Laroche Y,Derclaye I

    更新日期：1986-08-01 00:00:00

  • Detection of feline haemoplasma species in experimental infections by in-situ hybridisation.

    abstract：:The aim of this study was to use fluorescence in-situ hybridisation (FISH) to search for the tissues and cell types important in survival and persistence of Mycoplasma haemofelis, "Candidatus Mycoplasma haemominutum" or "Candidatus Mycoplasma turicensis" in infected cats. A 16S rDNA probe for each species was applied ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2010.09.003

    authors： Peters IR,Helps CR,Willi B,Hofmann-Lehmann R,Gruffydd-Jones TJ,Day MJ,Tasker S

    更新日期：2011-02-01 00:00:00

  • Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora.

    abstract：:Escherichia coli O157:H7 is a food-borne pathogen that can cause hemorrhagic colitis and, occasionally, hemolytic uremic syndrome, a sequela of infection that can result in renal failure and death. Here we sought to model the pathogenesis of orally-administered E. coli O157:H7 in BALB/c mice with an intact intestinal ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2010.01.003

    authors： Mohawk KL,Melton-Celsa AR,Zangari T,Carroll EE,O'Brien AD

    更新日期：2010-03-01 00:00:00

  • Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria.

    abstract：:Siderophores are low molecular weight molecules that allow bacteria to acquire iron from host cell proteins. 2,3-dihydroxybenzoic acid (DHBA) is the only known siderophore produced by the intracellular pathogen Brucella abortus. Here its role in virulence was assessed by evaluating the ability of a mutant with a disru...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2002.0500

    authors： Parent MA,Bellaire BH,Murphy EA,Roop RM 2nd,Elzer PH,Baldwin CL

    更新日期：2002-05-01 00:00:00

  • Reduced virulence of a hfq mutant of Pseudomonas aeruginosa O1.

    abstract：:The Sm-like protein Hfq has been implicated in the regulation of sigmaS-dependent and sigmaS-independent genes in E. coli and in the regulation of virulence factors in both, Yersinia enterocolitica and Brucella abortus. Here, we have studied the effect of Hfq on virulence and stress response of Pseudomonas aeruginosa ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/s0882-4010(03)00149-9

    authors： Sonnleitner E,Hagens S,Rosenau F,Wilhelm S,Habel A,Jäger KE,Bläsi U

    更新日期：2003-11-01 00:00:00

  • Isolates of the Enterobacter cloacae complex induce apoptosis of human intestinal epithelial cells.

    abstract：:Strains of the Enterobacter cloacae complex are becoming increasingly important human pathogen. The aim of the study was to identify, by sequencing the hsp60 gene, the species of clinical isolates phenotypically identified as E. cloacae and to examine them for virulence-associated properties: the ability of adhesion, ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2010.04.003

    authors： Krzymińska S,Koczura R,Mokracka J,Puton T,Kaznowski A

    更新日期：2010-09-01 00:00:00

  • Comparison of the pulmonary response against lethal and non-lethal intranasal challenges with two different pneumococcal strains.

    abstract：:The differences between the immune response elicited during a self-limiting and a life-threatening lung infection with Streptococcus pneumoniae was analyzed in a mouse model of intranasal challenge using two different pneumococcal strains. M10, a serotype 11A strain, induced an early response within the first 12h afte...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2009.05.005

    authors： Ferreira DM,Moreno AT,Cianciarullo AM,Ho PL,Oliveira ML,Miyaji EN

    更新日期：2009-09-01 00:00:00

  • Use of confocal microscopy to detect Salmonella typhimurium within host cells associated with Spv-mediated intracellular proliferation.

    abstract：:The major limitation in histological examination of orally inoculated mice of Salmonella typhimurium has been the difficulty of attaining high enough levels for immunochemical detection. This problem has been solved by the use of confocal laser scanning microscopy (CLSM) analysis, which allows detection of bacteria in...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0370

    authors： Matsui H,Eguchi M,Kikuchi Y

    更新日期：2000-07-01 00:00:00

  • Antimicrobial and antibiofilm activity of the benzoquinone oncocalyxone A.

    abstract：:Resistance to antimicrobials is a challenging issue that complicates the treatment of infections caused by bacteria and fungi, thus requiring new therapeutic options. Oncocalyxone A, a benzoquinone obtained from Auxemma oncocalyx (Allem) Taub has several biological effects; however, there is no data on its antimicrobi...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104513

    authors： da Silva RE,Ribeiro FOS,de Carvalho AMA,Daboit TC,Marinho-Filho JDB,Matos TS,Pessoa ODL,de Souza de Almeida Leite JR,de Araújo AR,Dos Santos Soares MJ

    更新日期：2020-12-01 00:00:00

  • Differential expression of structural and functional proteins during bean common mosaic virus-host plant interaction.

    abstract：:Bean common mosaic virus (BCMV), the most common seed-borne pathogen in Phaseolus vulgaris L. is known to cause severe loss in productivity across the globe. In the present study, proteomic analyses were performed for leaf samples from control (healthy) and susceptible BCMV infected plants. The differential expression...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103812

    authors： Kumar S,Dhembla C,P H,Sundd M,Patel AK

    更新日期：2020-01-01 00:00:00

  • The role of fimbriae of uropathogenic Escherichia coli as carriers of the adhesin involved in mannose-resistant hemagglutination.

    abstract：:The gene clusters encoding various P-fimbriae (F7(1), F7(2), F9 and F11) were compared. Deletion plasmids that lack the gene encoding the fimbrillin were derived from these gene clusters. Introduction of these deletion plasmids into an E. coli K12 strain resulted in non-fimbriated cells that still showed mannose-resis...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(86)90031-8

    authors： van Die I,Zuidweg E,Hoekstra W,Bergmans H

    更新日期：1986-02-01 00:00:00

  • Differences in pathogenicity and virulence-associated gene expression among Pasteurella multocida strains with high and low virulence in a lung tissue model.

    abstract：:Pasteurella multocida capsular type A can cause a pulmonary infection, leading to serious pecuniary losses in cattle. The heterogeneity of infection outcome of P. multocida strains showing different virulence may be related to divergent expression of virulence genes. In this study, we compared the transcriptional resp...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103911

    authors： Cheng Y,Wang K,Lin L,Zhao X,Pan Z,Zhou Z

    更新日期：2020-03-01 00:00:00

  • Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.

    abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) is acknowledged a fulminating infectious pathogen affecting the pig farming industry, and current vaccines and drugs could hardly inhibit this virus. The 2', 5'-oligoadenylate synthetase (OASs) have antiviral activities, but the role(s) played by porcine OAS2...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.08.011

    authors： Zhao M,Wan B,Li H,He J,Chen X,Wang L,Wang Y,Xie S,Qiao S,Zhang G

    更新日期：2017-10-01 00:00:00

  • Identification and expression of nor efflux family genes in Staphylococcus epidermidis that act against gatifloxacin.

    abstract：:NorA, NorB, and NorC are efflux proteins in the Nor family that regulate the secretion of fluoroquinolones, and MgrA/NorR is a transcription factor of the Nor family. Overexpression of Nor family proteins provides fluoroquinolone resistance in Staphylococcus aureus. However, in coagulase-negative staphylococci (CNS), ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2012.03.001

    authors： Juárez-Verdayes MA,Parra-Ortega B,Hernández-Rodríguez C,Betanzos-Cabrera G,Rodríguez-Martínez S,Cancino-Diaz ME,Cancino-Diaz JC

    更新日期：2012-06-01 00:00:00

  • Lithium chloride confers protection against viral myocarditis via suppression of coxsackievirus B3 virus replication.

    abstract：:Viral myocarditis (VMC) is a type of inflammation affecting myocardial cells caused by viral infection and has been an important cause of dilated cardiomyopathy (DCM) worldwide. Type B3 coxsackievirus (CVB3), a non-enveloped positive-strand RNA virus of the Enterovirus genus, is one of most common agent of viral myoca...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104169

    authors： Zhao Y,Yan K,Wang Y,Cai J,Wei L,Li S,Xu W,Li M

    更新日期：2020-07-01 00:00:00

  • Interaction of coagulase-negative Staphylococcus species with bovine mammary epithelial cells.

    abstract：:Three coagulase-negative Staphylococcus species (CNS) (Staphylococcus epidermidis, Staphylococcus xylosus and Staphylococcus hyicus), from the milk of cows with mastitis, were used to evaluate adherence to and internalization by bovine mammary epithelial cells, and to investigate involvement of host cell signal transd...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2001.0465

    authors： Almeida RA,Oliver SP

    更新日期：2001-11-01 00:00:00

  • A chromosomal integration system for stabilization of heterologous genes in Salmonella based vaccine strains.

    abstract：:We have developed a system whereby heterologous DNA encoding an antigen from an enteropathogen may be recombined into the chromosome of an attenuated Salmonella carrier strain. The system involves two steps: (i) integration of a hisOG deletion mutation into the chromosome; (ii) replacement of the hisOG deletion by the...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(88)90002-2

    authors： Hone D,Attridge S,van den Bosch L,Hackett J

    更新日期：1988-12-01 00:00:00

  • Reactivity of Haemophilus influenzae type b anti-pili antibodies.

    abstract：:The reactivity of anti-pilus antibodies to native and denatured Haemophilus influenzae b (Hib) pili was studied using rabbit serum prepared against piliated H. influenzae b strain M43 (p+) and adsorbed with its non-piliated variant, strain M42 (p-). The specificity of the adsorbed serum for Hib pili was documented by ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(89)90049-1

    authors： Gilsdorf JR,Forney LJ,LiPuma JJ

    更新日期：1989-10-01 00:00:00

  • Isolation and characterization of a broad-spectrum phage of multiple drug resistant Salmonella and its therapeutic utility in mice.

    abstract：:Salmonella are causes of livestock, poultry, and other animal diseases but they also have the potential to infect people. Currently, antibiotics are the first choice for treatment of Salmonella infections. Thus, the utility of phage has become the research focus for scientists for several reasons. There are efficient,...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.10.042

    authors： Tang F,Zhang P,Zhang Q,Xue F,Ren J,Sun J,Qu Z,Zhuge X,Li D,Wang J,Jiang M,Dai J

    更新日期：2019-01-01 00:00:00

  • Lactobacillus paracasei 28.4 reduces in vitro hyphae formation of Candida albicans and prevents the filamentation in an experimental model of Caenorhabditis elegans.

    abstract：:The objective of this study was to evaluate the influence of microbe-microbe interactions to identify a strain of Lactobacillus that could reduce the filamentation of Candida albicans ATCC 18804 using in vitro and in vivo models. Thus presenting a probiotic effect against the fungal pathogen. First, we analyzed the ab...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.02.019

    authors： de Barros PP,Scorzoni L,Ribeiro FC,Fugisaki LRO,Fuchs BB,Mylonakis E,Jorge AOC,Junqueira JC,Rossoni RD

    更新日期：2018-04-01 00:00:00

  • Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response.

    abstract：:In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both e...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2008.02.004

    authors： Penttilä T,Haveri A,Tammiruusu A,Vuola JM,Lahesmaa R,Puolakkainen M

    更新日期：2008-07-01 00:00:00

  • Zero valent silver nanoparticles capped with capsaicinoids containing Capsicum annuum extract, exert potent anti-biofilm effect on food borne pathogen Staphylococcus aureus and curtail planktonic growth on a zebrafish infection model.

    abstract：:Food plants Hungarian wax pepper (HWP) and Green Bell pepper (GBP), belonging to Capsicum annuum were utilized for biogenic fabrication of zero valent, nano-silver (AgNPs) through a photo-mediation procedure. In the bacterial strains evaluated, HWP/GBP AgNPs demonstrated effective bacteriostatic and bactericidal effec...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.08.053

    authors： Lotha R,Shamprasad BR,Sundaramoorthy NS,Ganapathy R,Nagarajan S,Sivasubramanian A

    更新日期：2018-11-01 00:00:00

  • Induced frameshifting mechanism of replication for an information-carrying scrapie prion.

    abstract：:A specific mistranslation mechanism for the replication of an infectious protein is described. The feedback mechanism requires the infectious agent to induce concerted frameshifts during the translation of a cellular gene. Each module of the tandem repeat region of the gene encoding the prion protein (PrP) associated ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/0882-4010(89)90098-3

    authors： Wills PR

    更新日期：1989-04-01 00:00:00

  • Inflammatory response induced by Helicobacter pylori infection in lung.

    abstract：:Helicobacter pylori is a microorganism that in the last years has been associated with extragastric disorders such as respiratory diseases, however, its impact on lung is partially understood. The aim of this work was to study infection impact of H. pylori on the inflammatory markers expression at the pulmonary level ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104103

    authors： Arismendi Sosa AC,Salinas Ibáñez AG,Pérez Chaca MV,Penissi AB,Gómez NN,Vega AE

    更新日期：2020-02-26 00:00:00

  • Sodium acetate inhibits Staphylococcus aureus internalization into bovine mammary epithelial cells by inhibiting NF-κB activation.

    abstract：:Bovine mastitis is one of the most costly and prevalent disease affecting dairy cows worldwide. It was reported that Staphylococcus aureus could internalize into bovine mammary epithelial cells (bMEC) and induce mastitis. Some short chain fatty acids (SCFA) have shown to suppress S. aureus invasion into bMEC and regul...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.03.030

    authors： Wei Z,Xiao C,Guo C,Zhang X,Wang Y,Wang J,Yang Z,Fu Y

    更新日期：2017-06-01 00:00:00

  • Use of incompatible plasmids to control expression of antigen by Salmonella typhimurium and analysis of immunogenicity in mice.

    abstract：:Salmonella spp. have been investigated as live vaccine vectors because they are heat stable and can elicit humoral, cellular, and secretory immune responses. However, the expression of some foreign antigens is toxic to bacterial vectors. We therefore studied an approach for the controlled expression of antigen in Salm...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1993.1060

    authors： Ervin SE,Small PA Jr,Gulig PA

    更新日期：1993-08-01 00:00:00