The role of fimbriae of uropathogenic Escherichia coli as carriers of the adhesin involved in mannose-resistant hemagglutination.

Abstract:

:The gene clusters encoding various P-fimbriae (F7(1), F7(2), F9 and F11) were compared. Deletion plasmids that lack the gene encoding the fimbrillin were derived from these gene clusters. Introduction of these deletion plasmids into an E. coli K12 strain resulted in non-fimbriated cells that still showed mannose-resistant hemagglutination (MRHA). However when introduced into wild type E. coli strains no MRHA was observed. Derivatives of the wild type E. coli strains with reduced amounts of O-antigen on the other hand showed MRHA when harbouring these plasmids. These results indicate that adhesion and presence of fimbriae are not necessarily linked. P-fimbriae could function as a carrier for the adhesin and thus endow adhesive capacity to cells with a complete O-antigen.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

van Die I,Zuidweg E,Hoekstra W,Bergmans H

doi

10.1016/0882-4010(86)90031-8

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

51-6

issue

1

eissn

0882-4010

issn

1096-1208

pii

0882-4010(86)90031-8

journal_volume

1

pub_type

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