Abstract：
:Aeromonosis is a fish disease that leads to haemorrhagic septicaemia and high mortality. The detection of early behavioural changes associated to this disease could be helpful in anticipating the initiation of treatment, increasing the probability of success. The influence of this disease on the hypothalamic-pituitary-interrenal (HPI) axis and on the brain expression of heat shock proteins (HSP) is little known. Therefore, the aim of this study was to evaluate the effect of Aeromonas hydrophila infection on individual behaviour and brain expression of genes related to stress (slc6a2, hsp90, hspa12a, hsd20b, hsd11b2, crh) in silver catfish (Rhamdia quelen). Thirty fish were divided into healthy and infected groups. The fish of the infected group were inoculated intramuscularly with 50 μL of bacterial suspension (6.4 × 108 CFU/mL), while control animals received 50 μL of saline. On day five post-infection, animals were submitted to the novel tank test, euthanized, and the brain was collected for molecular analysis. Infected fish swam more in the unknown aquarium and presented an increase in brain expression of genes related to HSP (hspa12a) and the route of cortisol synthesis (crh) when compared to uninfected fish. Therefore, this disease causes hyperlocomotion related to stress.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Bandeira Junior G,de Freitas Souza C,Descovi SN,Antoniazzi A,Cargnelutti JF,Baldisserotto Bdoi
10.1016/j.micpath.2019.05.017subject
Has Abstractpub_date
2019-07-01 00:00:00pages
261-265eissn
0882-4010issn
1096-1208pii
S0882-4010(19)30448-6journal_volume
132pub_type
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