Abstract:
:Iron is an environmental signal which regulates the coordinate expression of genes associated with virulence in many pathogenic bacteria. In response to iron-deprivation, lysogenic Corynebacterium diphtheriae C7 (beta) synthesizes and secretes diphtheria toxin and siderophore and induces a high-affinity iron uptake system. Diphtheria toxin is encoded by beta phage, but genes for siderophore production are encoded on the bacterial chromosome. Diphtheria toxin and siderophore production were shown to be coordinately induced during late logarithmic phase growth of wild-type C7(beta) in iron-limited medium. C. diphtheriae mutant C7hm723 produced siderophore and toxin constitutively under low-iron and high-iron conditions, but in mutants HC1, HC3, HC4, and HC5 their synthesis was partially repressed under high-iron conditions. The phenotypes of HC1, HC3, HC4, and HC5 are consistent with their severe defects in iron uptake, but the phenotype of C7hm723 is more likely to be explained by inactivation of the repressor for the iron regulon of C. diphtheriae.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Tai SP,Krafft AE,Nootheti P,Holmes RKdoi
10.1016/0882-4010(90)90015-isubject
Has Abstractpub_date
1990-10-01 00:00:00pages
267-73issue
4eissn
0882-4010issn
1096-1208pii
0882-4010(90)90015-Ijournal_volume
9pub_type
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
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doi:10.1016/0882-4010(92)90034-l
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pub_type: 杂志文章
doi:10.1016/j.micpath.2019.103902
更新日期:2020-02-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2007.08.002
更新日期:2008-02-01 00:00:00
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journal_title:Microbial pathogenesis
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更新日期:2017-02-01 00:00:00
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更新日期:2016-06-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1006/mpat.1993.1047
更新日期:1993-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0882-4010(89)90032-6
更新日期:1989-08-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1006/mpat.1998.0226
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pub_type: 杂志文章
doi:10.1016/j.micpath.2016.01.010
更新日期:2016-05-01 00:00:00
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2019.103549
更新日期:2019-08-01 00:00:00
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journal_title:Microbial pathogenesis
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更新日期:2018-06-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2018.03.055
更新日期:2018-05-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/0882-4010(87)90016-7
更新日期:1987-12-01 00:00:00
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2018.06.013
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2016.07.002
更新日期:2016-09-01 00:00:00
abstract::Vibrio parahaemolyticus is a leading cause of seafood-associated bacterial gastroenteritis. The pathogen produces the thermostable direct hemolysin (TDH), which is the sole cause of the Kanagawa phenomenon (KP), a special β-type haemolysis in the Wagatsuma agar. TDH also exerts several other biological activities, the...
journal_title:Microbial pathogenesis
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00