A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes.

abstract：:Anthrax lethal factor (LF), a Zn(2+)-dependent metalloprotease, is a key virulence component of anthrax toxin. Here, we used proteolytic assay-based screening to identify novel LF inhibitors from a naturally extracted chemical library. The screening identified four compounds that inhibited in vitro proteolytic activit...

journal_title：Microbial pathogenesis

authors： Park HC,Sung SR,Lim SM,Lee JS,Kim SK,Yoon MY

更新日期：2012-08-01 00:00:00

abstract：:Group A streptococci demonstrate a number of distinct ways to interact with the human fibrinolytic system to acquire unregulatable cell-surface enzymatic activity. Interactions between bacteria, fibrinogen, streptokinase and plasminogen resulted in acquisition of cell-associated enzymatic activity that can lyse fibrin...

journal_title：Microbial pathogenesis

authors： Wang H,Lottenberg R,Boyle MD

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Since the pre-transplant status affects the renal transplantation success and ultimately the survival rate, identifying the probable risk factors that increase the chance of BK virus replication in end-stage renal disease patients can be included in proposing proper surveillance guidelines during pre and pos...

journal_title：Microbial pathogenesis

authors： Pourkazemi A,Shenagari M,Monfared A,Hassankhani A,Chamaki FN,Khosravi M,Lebadi M,Ashrafkhani B

更新日期：2020-12-01 00:00:00

abstract：:The emergence of extensively drug-resistant (XDR) Acinetobacter baumannii strains and the limited number of efficacious antibiotics demonstrate an urgent need to develop novel agents to treat infections caused by this dangerous pathogen. To find antimicrobial peptides against A. baumannii growing either in planktonic ...

journal_title：Microbial pathogenesis

authors： Irani N,Basardeh E,Samiee F,Fateh A,Shooraj F,Rahimi A,Shahcheraghi F,Vaziri F,Masoumi M,Pazhouhandeh M,Siadat SD,Kazemi-Lomedasht F,Jamnani FR

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Bacterial adhesins play an important role in the bacterial attachment and colonization. The aim of this study was comparison of adhesin genes expression in the planktonic and biofilm mode of growth among ESBL-non-producers isolates of K. oxytoca and effect of imipenem. MATERIALS AND METHODS:A total of eight...

journal_title：Microbial pathogenesis

authors： Alkhudhairy MK,Alshadeedi SMJ,Mahmood SS,Al-Bustan SA,Ghasemian A

更新日期：2019-09-01 00:00:00

abstract：:BALB/c mice were infected with 10(5) colony forming units (cfu) of Mycobacterium avium TMC 702 i.v. and the growth of the inoculum followed in the spleens of control mice. Other infected mice given weekly doses of 1 microgram of TGF-b1 or weekly doses of 2 mg of a rabbit antiserum against mouse TGF-b1 were evaluated f...

journal_title：Microbial pathogenesis

authors： Denis M,Ghadirian E

更新日期：1991-11-01 00:00:00

abstract：:Lignin, a common natural polymers, is abundant and complex, and termites can break down and utilize the lignin in their food. In this study an attempt was made to isolate and characterize the lignolytic bacteria from termite (Reticulitermes chinensis Snyder) gut. Two strains (PY12 and MX5) with high lignin peroxidase ...

journal_title：Microbial pathogenesis

authors： Zhou H,Guo W,Xu B,Teng Z,Tao D,Lou Y,Gao Y

更新日期：2017-11-01 00:00:00

abstract：:To examine the genetic control of acute and late disease induced by a murine coronavirus, strain JHM (JHMV), BALB/cHeA, STS/A, F1 hybrids and 13 recombinant inbred (RI) strains between BALB/cHeA and STS/A mouse strains were inoculated intracerebrally with 100 pfu of JHMV. All the BALB/cHeA mice died within 2 weeks fro...

journal_title：Microbial pathogenesis

authors： Kyuwa S,Yamaguchi K,Toyoda Y,Fujiwara K,Hilgers J

更新日期：1992-02-01 00:00:00

abstract：:Our previous studies have shown that the adhesive ability of Enterococcus faecalis is dependent on the strain and is further modified by growth in serum. The data reported here demonstrate that E. faecalis adherence is mediated by carbohydrate residues present on the bacterial cell surface. Some of these (D-mannose an...

journal_title：Microbial pathogenesis

authors： Guzmàn CA,Pruzzo C,Platè M,Guardati MC,Calegari L

更新日期：1991-12-01 00:00:00

abstract：:Application of antibiotics to combat bacterial diseases in fish has been criticized due to likely emergence of drug resistance. Therefore, investigation of new bioactive compounds from natural sources has been taken into account. This study was designed to purify and characterize the bioactive compound in the cell fre...

journal_title：Microbial pathogenesis

authors： Mukherjee A,Banerjee G,Mukherjee P,Ray AK,Chandra G,Ghosh K

更新日期：2019-05-01 00:00:00

abstract：:In the present study, we synthesized and characterized a probiotic Bacillus licheniformis cell free extract (BLCFE) coated silver nanoparticles (BLCFE-AgNPs). These BLCFE-AgNPs were characterized by UV-visible spectrophotometer, XRD, EDX, FTIR, TEM and AFM. A strong surface plasmon resonance centered at 422 nm in UV-v...

journal_title：Microbial pathogenesis

authors： Shanthi S,Jayaseelan BD,Velusamy P,Vijayakumar S,Chih CT,Vaseeharan B

更新日期：2016-04-01 00:00:00

abstract：:The gene clusters encoding various P-fimbriae (F7(1), F7(2), F9 and F11) were compared. Deletion plasmids that lack the gene encoding the fimbrillin were derived from these gene clusters. Introduction of these deletion plasmids into an E. coli K12 strain resulted in non-fimbriated cells that still showed mannose-resis...

journal_title：Microbial pathogenesis

authors： van Die I,Zuidweg E,Hoekstra W,Bergmans H

更新日期：1986-02-01 00:00:00

abstract：:Two highly passaged laboratory strains of human cytomegalovirus (HCMV), AD169 and Towne, were tested for their ability to infect and replicate in THP-1 myelomonocytic cells differentiated with 12-O-tetradecanoylphorbol-13-acetate (TPA). TPA treatment of human THP-1 cells increased the number of cells that expressed HC...

journal_title：Microbial pathogenesis

authors： Turtinen LW,Seufzer BJ

更新日期：1994-05-01 00:00:00

abstract：:Clinical isolates of Pseudomonas aeruginosa are either invasive or cytotoxic towards mammalian epithelial cells, endothelial cells, and macrophages. Invasion requires host cell actin cytoskeleton function, and ExsA-regulated proteins of P. aeruginosa that inhibit invasion (ExoS and ExoT) can disrupt the cytoskeleton. ...

journal_title：Microbial pathogenesis

authors： Evans DJ,Kuo TC,Kwong M,Van R,Fleiszig SM

更新日期：2002-09-01 00:00:00

abstract：:Acute lung injury (ALI) is considered as an uncontrolled inflammatory response that can leads to acute respiratory distress syndrome (ARDS), which limits the therapeutic strategies. Ginsenosides Rb1 (Rb1), an active ingredient obtained from Panax ginseng, possesses a broad range of pharmacological and medicinal proper...

journal_title：Microbial pathogenesis

authors： Shaukat A,Yang C,Yang Y,Guo YF,Jiang K,Guo S,Liu J,Zhang T,Zhao G,Ma X,Wu Z,Zhou Q,Akhtar M,Zahoor A,Umar T,Shaukat I,Hanif S,Rajput SA,Hassan M,Mehmood K,Hua Z,Xiaoyan W,Nannan Y,Deng G

更新日期：2020-06-01 00:00:00

abstract：:Streptococcus pneumoniae attach to human pharyngeal epithelial cells through the specific interaction of bacterial surface adhesins with glycoconjugate receptors. The present study defines the adhesin as a molecule bridging between an anchoring site in the bacterial cell wall and the epithelial cell receptor. The natu...

journal_title：Microbial pathogenesis

authors： Andersson B,Beachey EH,Tomasz A,Tuomanen E,Svanborg-Edén C

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:It is generally considered that HLA-Ⅱ genes contribute to the Helicobacter pylori (Hp) infection and disease development process. AIMS:To perform a meta-analysis to explore the relationship between HLA-Ⅱgene polymorphism and host susceptibility to Hp infection. METHODS:Relevant cohort studies, case-control...

journal_title：Microbial pathogenesis

authors： Wang J,Zhang Q,Liu Y,Han J,Ma X,Luo Y,Liang Y,Zhang L,Hu Y

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Canine distemper virus (CDV) can cause a highly contagious disease to canid. However, how CDV affects peripheral blood lymphocyte (PBL) remains unclear. METHODS:In this study, CDV infected PBL was cultured to investigate the effect of CDV on the differentiation of lymphocytes and the mRNA expression of infl...

journal_title：Microbial pathogenesis

authors： Song K,Wu ZM,Peng LY,Yuan M,Huang JN,Zhang CL,Fu BD,Yi PF,Shen HQ

更新日期：2019-06-01 00:00:00

abstract：:HTLV-1 infects principally CD4+ T cells that are the main reservoirs of the virus in vivo, which play an important role in the immunological response. Most of the infected patients are asymptomatic. However, 2-3% of patients will develop HAM/TSP or Adult T lymphoma. HAM/TSP is a chronic inflammatory disease of the cen...

journal_title：Microbial pathogenesis

authors： da Silva Dias GA,Sousa RCM,Gomes LF,Caldas CAM,Nassiri R,Quaresma JAS,Fuzii HT

更新日期：2016-03-01 00:00:00

abstract：:Edwardsiella tarda, an important fish pathogenic bacterium, could utilize type III secretion system (T3SS) to transfer multiple effector proteins into host cells during infection. EseG was identified to be an E. tarda T3SS effector, which could be injected by T3SS into non-phagocytic cells. Since E. tarda is a faculta...

journal_title：Microbial pathogenesis

authors： Fang S,Zhang L,Lou Y,Yang D,Wang Q,Zhang Y,Liu Q

更新日期：2016-08-01 00:00:00

abstract：:This study was design to evaluate the physiological properties of bacteriophage-insensitive Klebsiella pneumoniae (BIKP) mutants in association with the antibiotic cross-resistance, β-lactamase activity, and gene expression. Klebsiella pneumoniae ATCC 23357(KPWT), ciprofloxacin-induced antibiotic-resistant K. pneumoni...

journal_title：Microbial pathogenesis

authors： Uddin MJ,Kim B,Dawan J,Ding T,Kim JC,Ahn J

更新日期：2019-10-01 00:00:00

abstract：:Until recently, glycoproteins had only been described in eukaryotes. However, advances in detection methods and genome analyses have allowed the discovery of N-linked or O-linked glycoproteins, similar to those found in eukaryotes, in some bacterial species. These prokaryotic glycoproteins play roles in adhesion, solu...

journal_title：Microbial pathogenesis

authors： Shoji M,Nakayama K

更新日期：2016-05-01 00:00:00

abstract：:The high incidence of bacterial respiratory infections has led to a focus on evaluating the human respiratory microbiome. Studies based on culture-based and molecular methods have shown an increase in the bacterial community that includes the bacterial phyla Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteri...

journal_title：Microbial pathogenesis

authors： Maleki A,Zamirnasta M,Taherikalani M,Pakzad I,Mohammadi J,Krutova M,Kouhsari E,Sadeghifard N

更新日期：2020-06-01 00:00:00

abstract：:HPV persistent infection is a main event leading to the development of cervical intraepithelial neoplasia and cervical cancer. Earlier to distinguish HPV persistent and transient infection is meaningful but the methods are limited. This study used 16S rDNA sequencing to determine the cervicovaginal microbiota of HPV p...

journal_title：Microbial pathogenesis

authors： Qingqing B,Jie Z,Songben Q,Juan C,Lei Z,Mu X

更新日期：2020-11-15 00:00:00

abstract：:Quorum sensing (QS), a cell-to-cell communication mechanism present in many bacterial species plays a key role in regulating the virulence factor and biofilm formation in many pathogens, which causes severe public health risk. Therefore, interfering with QS mechanism offers an attractive strategy to combat bacterial i...

journal_title：Microbial pathogenesis

authors： Vasavi HS,Sudeep HV,Lingaraju HB,Shyam Prasad K

更新日期：2017-03-01 00:00:00

abstract：:The type III secretion system of Pseudomonas aeruginosa, responsible for acute infection, is composed of over twenty proteins that facilitate cytotoxin injection directly into host cells. Integral to this process is production and secretion of PcrV. Administration of a recently developed, anti-PcrV immunoglobulin, eit...

journal_title：Microbial pathogenesis

authors： Lynch SV,Flanagan JL,Sawa T,Fang A,Baek MS,Rubio-Mills A,Ajayi T,Yanagihara K,Hirakata Y,Kohno S,Misset B,Nguyen JC,Wiener-Kronish JP

更新日期：2010-06-01 00:00:00

abstract：:Food-production animals were considered to be a major reservoir of antimicrobial-resistant bacteria and clinically relevant pathogens. The potential of commensal Escherichia coli from pigs as a source of opportunistic pathogens associated with extraintestinal infections in humans needs to be assessed. In this study, 1...

journal_title：Microbial pathogenesis

authors： Li Y,Ma X,Li C,Dai X,Zhang L

更新日期：2020-11-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are two major omega-3 polyunsaturated fatty acids (n-3 PUFAs) with antimicrobial properties. In this study, we evaluated the potential antibacterial and antibiofilm activities of DHA and EPA against two periodontal pathogens, Porphyromonas gingivalis (P. gingi...

journal_title：Microbial pathogenesis

authors： Sun M,Zhou Z,Dong J,Zhang J,Xia Y,Shu R

更新日期：2016-10-01 00:00:00

abstract：:Neisseria meningitidis is normally a human nasopharyngeal commensal but is also capable of causing life-threatening sepsis and meningitis. N. meningitidis secretes several virulence-associated proteins including Neisserial autotransporter lipoprotein (NalP), an immunogenic, type Va autotransporter harboring an S8-fami...

journal_title：Microbial pathogenesis

authors： Dufailu OA,Mahdavi J,Ala'Aldeen DAA,Wooldridge KG,Oldfield NJ

更新日期：2018-11-01 00:00:00

abstract：:The genus Aeromonas comprises more than thirty Gram-negative bacterial species which mostly act as opportunistic microorganisms. These bacteria are distributed naturally in diverse aquatic ecosystems, where they are easily isolated from animals such as fish and crustaceans. A capacity for adaptation also makes Aeromon...

journal_title：Microbial pathogenesis

authors： Gonçalves Pessoa RB,de Oliveira WF,Marques DSC,Dos Santos Correia MT,de Carvalho EVMM,Coelho LCBB

更新日期：2019-05-01 00:00:00