Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor.

abstract：:Porphyromonas gingivalis is capable of in vitro growth when iron sources are either complexed to hemin or host iron transport proteins, or exist in an inorganic form. This study examined the effect of these iron sources on outer membrane protein (OMP) expression in P. gingivalis W50. Hemin (iron) starved P. gingivalis...

journal_title：Microbial pathogenesis

authors： Bramanti TE,Holt SC

更新日期：1992-07-01 00:00:00

abstract：:Roselle, or Jamaica sorrel (Hibiscus sabdariffa) is a popular vegetable in many tropical regions, cultivated for its leaves, seeds, stems and calyces which, the dried calyces are used to prepare tea, syrup, jams and jellies and as beverages. The main objectives of this study were to identify and characterise fungal pa...

journal_title：Microbial pathogenesis

authors： Eslaminejad T,Zakaria M

更新日期：2011-11-01 00:00:00

abstract：:Recent studies have been considered to symbiotic interactions of the human gastrointestinal microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota continuously stimulates the immune system against opportunistic and pathogen bacteria from infancy. Changes in gastrointestinal microbiota ...

journal_title：Microbial pathogenesis

authors： Gholizadeh P,Mahallei M,Pormohammad A,Varshochi M,Ganbarov K,Zeinalzadeh E,Yousefi B,Bastami M,Tanomand A,Mahmood SS,Yousefi M,Asgharzadeh M,Kafil HS

更新日期：2019-02-01 00:00:00

abstract：:Recent research has shown broad antifungal activity of the classic antidepressants selective serotonin reuptake inhibitors (SSRIs). This fact, combined with the increased cross-resistance frequency of the genre Candida regarding the main treatment today, fluconazole, requires the development of novel therapeutic strat...

journal_title：Microbial pathogenesis

authors： Costa Silva RA,da Silva CR,de Andrade Neto JB,da Silva AR,Campos RS,Sampaio LS,do Nascimento FBSA,da Silva Gaspar B,da Cruz Fonseca SG,Josino MAA,Grangeiro TB,Gaspar DM,de Lucena DF,de Moraes MO,Cavalcanti BC,Nobre Júnior H

更新日期：2017-06-01 00:00:00

abstract：:We have described a new class of live attenuated salmonella vaccines harbouring lesions in htrA, a stress protein gene previously. The virulence and invasiveness of Salmonella htrA mutants was investigated in three models of increased susceptibility to Salmonella infection. These included BALB/c mice, either given sub...

journal_title：Microbial pathogenesis

authors： Strahan K,Chatfield SN,Tite J,Dougan G,Hormaeche CE

更新日期：1992-04-01 00:00:00

abstract：:The cAMP content of Trypanosoma brucei increases in parallel with ascending mammalian parasitemia to very high levels just before differentiation of the long-slender to the short-stumpy bloodstream form. Because expression of myc oncogenes is required for vertebrate cells to interpret proliferation signals and decline...

journal_title：Microbial pathogenesis

authors： Davis CE,Colmerauer ME,Kim CH,Matthews B,Guiney DG

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Brucella is a Gram-negative and facultative intracellular organism that causes brucellosis, a common zoonotic disease. Over 500,000 people are annually affected by brucellosis. Brucella is highly infectious through inhalation route; for this reason it is used for biological warfare aims. This study aimed to ...

journal_title：Microbial pathogenesis

authors： Abadi AH,Mahdavi M,Khaledi A,Esmaeili SA,Esmaeili D,Sahebkar A

更新日期：2018-08-01 00:00:00

abstract：:The Phytophthora capsici inflicts damage on numerous crop plants by secreting a series of pectinase including pectin methylesterase (PME). We identified a PME gene (pcpme6) from a genomic library of a highly virulent P. capsici strain SD33 which had an encoded a polypeptide of 348 amino acid residues with a predicted ...

journal_title：Microbial pathogenesis

authors： Feng B,Li P,Wang H,Zhang X

更新日期：2010-07-01 00:00:00

abstract：:NorA, NorB, and NorC are efflux proteins in the Nor family that regulate the secretion of fluoroquinolones, and MgrA/NorR is a transcription factor of the Nor family. Overexpression of Nor family proteins provides fluoroquinolone resistance in Staphylococcus aureus. However, in coagulase-negative staphylococci (CNS), ...

journal_title：Microbial pathogenesis

authors： Juárez-Verdayes MA,Parra-Ortega B,Hernández-Rodríguez C,Betanzos-Cabrera G,Rodríguez-Martínez S,Cancino-Diaz ME,Cancino-Diaz JC

更新日期：2012-06-01 00:00:00

abstract：:Nanotechnology is a potential area that revolutionizes almost every sector of life and is predicted to become a major economic force in the near future. Recently, nanomaterials have received great attention for their properties at nanoscale regime and their applications in many areas primarily, agriculture and food se...

journal_title：Microbial pathogenesis

authors： Chaudhry N,Dwivedi S,Chaudhry V,Singh A,Saquib Q,Azam A,Musarrat J

更新日期：2018-10-01 00:00:00

abstract：:To determine if RecA plays a role in the virulence of Brucella abortus, a B. abortus RecA mutant was constructed and its survival was examined in mice. The recA gene was cloned from a B. abortus genomic DNA library by complementation of an Escherichia coli recA mutant in the presence of methyl methanesulfonate (MMS). ...

journal_title：Microbial pathogenesis

authors： Tatum FM,Morfitt DC,Halling SM

更新日期：1993-03-01 00:00:00

abstract：:Phenotypic serum resistance of gonococci in urethral exudates is due to sialylation of lipopolysaccharide (LPS) by host cytidine 5'-monophospho-N-acetyl neuraminic acid (CMP-NANA). A surface structure was visible on gonococci [strain BS4 (agar)] that had been stained with ruthenium red after incubation with CMP-NANA. ...

journal_title：Microbial pathogenesis

authors： Fox AJ,Curry A,Jones DM,Demarco de Hormaeche R,Parsons NJ,Cole JA,Smith H

更新日期：1991-09-01 00:00:00

abstract：:Heterosporosis is an increasingly important microsporidian disease distributed worldwide, impacting wild and farmed-raised fish in both fresh and marine water environments. Twenty three out of 130 (17.69%) of the lizardfish Saurida lessepsianus were found to be naturally infected with microsporidian parasites. The rat...

journal_title：Microbial pathogenesis

authors： Al Quraishy S,Abdel-Gaber R,El Deeb N,Maher S,Al-Shaebi E,Abdel-Ghaffar F

更新日期：2019-05-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a neutrophil and T-lymphocyte chemotactic and activating factor. This cytokine is produced by many cell types including macrophages in response to a variety of microbial and non-microbial agents. In the present study, we determined the nucleotide sequence for bovine IL-8 cDNA. The amino acid se...

journal_title：Microbial pathogenesis

authors： Morsey MA,Popowych Y,Kowalski J,Gerlach G,Godson D,Campos M,Babiuk LA

更新日期：1996-04-01 00:00:00

abstract：:Pneumococcal surface protein A (PspA) is a widely studied pneumococcal protein, exposed at the surface of all strains. It is an important virulence factor, preventing complement deposition as well as inhibiting the lytic effects of lactoferrin over pneumococci. Several studies have investigated the use of PspA as a ca...

journal_title：Microbial pathogenesis

authors： Converso TR,Goulart C,Rodriguez D,Darrieux M,Leite LCC

更新日期：2017-08-01 00:00:00

abstract：:Oropharyngeal candidiasis is a frequent opportunistic infection associated with immunocompromised hosts. Candida albicans is the principal species responsible for this infection. Production of interleukin-8 (IL-8), by oral epithelial cells can be expected to play a major role in the recruitment and activation of profe...

journal_title：Microbial pathogenesis

authors： Dongari-Bagtzoglou A,Kashleva H

更新日期：2003-04-01 00:00:00

abstract：:Brucellosis is a worldwide zoonotic infectious disease that has significant economic effects on animal production and human health. The host macrophage -Brucella interaction is critical to the establishment of infections. Thus, the kinetic transcriptional profile of gene expression in macrophages infected with the Bru...

journal_title：Microbial pathogenesis

authors： Liu Q,Han W,Sun C,Zhou L,Ma L,Lei L,Yan S,Liu S,Du C,Feng X

更新日期：2012-05-01 00:00:00

abstract：:The present study was aimed to investigate and understand the mechanism of inhibitory effect of phenyl benzoxime on proliferation of SNU-306 cells. Proliferation of SNU-306 cells transfected with wild-type p53-induced phosphatase 1 (Wip1)-siRNA or treated with phenyl benzoxime was examined by 3-(4,5-dimethythiazol-2-y...

journal_title：Microbial pathogenesis

authors： Chen W,Tan Y,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:The non-coding RNA rprA can increase the resistance to ampicillin in Escherichia coli. METHODS:Bacterial DNA was extracted by boiling method and then amplified using polymerase chain reaction (PCR) with two different primer sets. Recombinant pET28a/rprA-sense and -antisense plasmids were separately transfer...

journal_title：Microbial pathogenesis

authors： Sahni A,Hajjari M,Raheb J,Foroughmand AM,Asgari M

更新日期：2019-04-01 00:00:00

abstract：:Enterotoxignenic Escherichia coli (ETEC)-associated colibacillosis causes high levels of morbidity and mortality in neonatal piglets. Vaccination is among effective strategy to fight against ETEC-related diseases. Bacterial ghosts (BGs) are empty bacterial envelopes, which substain subtle antigenic comformation in bac...

journal_title：Microbial pathogenesis

authors： Ran X,Chen X,Wang S,Chang C,Wen X,Zhai J,Ni H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In the current healthcare environment, an alarming rise in multi-drug resistant bacterial infections has led to a global health threat. The lack of new antibiotics has created a need for developing alternative strategies. OBJECTIVE:Understanding the antibacterial mechanisms of cinnamon and its constituents ...

journal_title：Microbial pathogenesis

authors： Vasconcelos NG,Croda J,Simionatto S

更新日期：2018-07-01 00:00:00

abstract：:Helicobacter pylori (H. pylori), which is a spiral-shaped Gram-negative microaerobic bacterium, is a causative pathogen. The entry of H. pylori into gastric epithelial cells involves various host signal transduction events, and its virulence factors can also cause a variety of biological responses. In this study, AGS ...

journal_title：Microbial pathogenesis

authors： Matsunaga S,Nishiumi S,Tagawa R,Yoshida M

更新日期：2018-11-01 00:00:00

abstract：:A recent study has described the normal vaginal bacterial community in giant pandas, but there is a lack of knowledge of the fungal community residing in the vagina of giant pandas. In order to comprehensively understand the vaginal fungal microbial diversity and abundance in giant pandas, high throughput sequencing w...

journal_title：Microbial pathogenesis

authors： Chen D,Li C,Feng L,Zhang Z,Zhang H,Cheng G,Li D,Zhang G,Wang H,Chen Y,Feng M,Wang C,Wu H,Deng L,Ming H,Yang X

更新日期：2018-02-01 00:00:00

abstract：:This study aimed to investigate the mechanism of lipopolysaccharide (LPS) released in the rumen on epithelium barrier function of goats fed a HC diet. Twelve Boer goats were randomly divided into two groups: low-concentrate(LC) diet and high-concentrate(HC) diet treatment. We found that the pH of rumen fluid in the HC...

journal_title：Microbial pathogenesis

authors： Zhang K,Meng M,Gao L,Tu Y,Bai Y

更新日期：2019-06-01 00:00:00

abstract：:Hap, an auto-transporter protein, is an antigenically conserved adhesion protein which is present on both typeable and nontypeable Haemophilus influenzae. This protein has central role in bacterial attachment to respiratory tract epithelial cells. A 1000bp C-terminal fragment of Hap passenger domain (HapS) from nontyp...

journal_title：Microbial pathogenesis

authors： Tabatabaee Bafroee AS,Siadat SD,Mousavi SF,Aghasadeghi MR,Khorsand H,Nejati M,Sadat SM,Mahdavi M

更新日期：2016-09-01 00:00:00

abstract：:Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to the yeast cell adhesin than does the parent Fn molecu...

journal_title：Microbial pathogenesis

authors： Penn C,Klotz SA

更新日期：1994-12-01 00:00:00

abstract：:Strains of the Enterobacter cloacae complex are becoming increasingly important human pathogen. The aim of the study was to identify, by sequencing the hsp60 gene, the species of clinical isolates phenotypically identified as E. cloacae and to examine them for virulence-associated properties: the ability of adhesion, ...

journal_title：Microbial pathogenesis

authors： Krzymińska S,Koczura R,Mokracka J,Puton T,Kaznowski A

更新日期：2010-09-01 00:00:00

abstract：:In this paper, we have reported the synthesis, characterization, and evaluation of antimicrobial and antioxidant potential of monodispersed Zinc Oxide (ZnO) nanoparticles synthesized by the room temperature precipitation (aqueous phase) and polyol method (organic phase). ZnO nanoparticle synthesized by both the method...

journal_title：Microbial pathogenesis

authors： Soren S,Kumar S,Mishra S,Jena PK,Verma SK,Parhi P

更新日期：2018-06-01 00:00:00

abstract：:The biodegradation of Aflatoxin B1 (AFB1) is an industry of increasing importance. Bacillus licheniformis BL-010 was isolated from the aflatoxin contaminated corn feed storage, and was shown to degrade AFB1 efficiently. Here we present the complete genome sequence of BL-010, the genome comprises 4,287,714 bp in a circ...

journal_title：Microbial pathogenesis

authors： He S,Feng K,Ding T,Huang K,Yan H,Liu X,Zhang Z

更新日期：2018-05-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (HMGR), an NADPH dependant enzyme catalyzes the synthesis of mevalonic acid from HMG-CoA required for isoprenoid biosynthesis. The HMGR gene from Leishmania donovani was cloned and expressed. Genome analysis of L. donovani revealed that HMGR gene having an open readin...

journal_title：Microbial pathogenesis

authors： Dinesh N,Pallerla DS,Kaur PK,Kishore Babu N,Singh S

更新日期：2014-01-01 00:00:00