Abstract:
:Recent research has shown broad antifungal activity of the classic antidepressants selective serotonin reuptake inhibitors (SSRIs). This fact, combined with the increased cross-resistance frequency of the genre Candida regarding the main treatment today, fluconazole, requires the development of novel therapeutic strategies. In that context, this study aimed to assess the antifungal potential of fluoxetine, sertraline, and paroxetine against fluconazole-resistant Candida spp. planktonic cells, as well as to assess the mechanism of action and the viability of biofilms treated with fluoxetine. After 24 h, the fluconazole-resistant Candida spp. strains showed minimum inhibitory concentration (MIC) in the ranges of 20-160 μg/mL for fluoxetine, 10-20 μg/mL for sertraline, and 10-100.8 μg/mL for paroxetine by the broth microdilution method (M27-A3). According to our data by flow cytometry, each of the SSRIs cause fungal death after damaging the plasma and mitochondrial membrane, which activates apoptotic signaling pathways and leads to dose-dependant cell viability loss. Regarding biofilm-forming isolates, the fluoxetine reduce mature biofilm of all the species tested. Therefore, it is concluded that SSRIs are capable of inhibit the growth in vitro of Candida spp., both in planktonic form, as biofilm, inducing cellular death by apoptosis.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Costa Silva RA,da Silva CR,de Andrade Neto JB,da Silva AR,Campos RS,Sampaio LS,do Nascimento FBSA,da Silva Gaspar B,da Cruz Fonseca SG,Josino MAA,Grangeiro TB,Gaspar DM,de Lucena DF,de Moraes MO,Cavalcanti BC,Nobre Júnior Hdoi
10.1016/j.micpath.2017.04.008subject
Has Abstractpub_date
2017-06-01 00:00:00pages
341-348eissn
0882-4010issn
1096-1208pii
S0882-4010(17)30122-5journal_volume
107pub_type
杂志文章abstract::Genital serovariants of Chlamydia trachomatis establish infection by attachment, entry and multiplication within human endometrial epithelial cells. In previous studies, a chlamydial recombinant Escherichia coli was identified which exhibited a specific adherent phenotype to endometrial epithelial cells closely resemb...
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2009.10.003
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2018.05.032
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doi:10.1016/j.micpath.2018.08.014
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doi:10.1016/j.micpath.2017.09.024
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/0882-4010(89)90110-1
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2018.07.026
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1006/mpat.1994.1023
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
pub_type: 评论,信件
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
doi:10.1016/j.micpath.2005.01.001
更新日期:2005-02-01 00:00:00
abstract::In this study experimental mouse model for Chlamydia pneumoniae infection was used to elucidate the nature of immune response developing during primary and secondary infection. First we examined the mononuclear cells from different lymphoid organs in BALB/c mice during C. pneumoniae infection and detected a strong lym...
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doi:10.1016/j.micpath.2009.01.006
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