Strategies and advancements in human microbiome description and the importance of culturomics.

abstract：:A variant of Vero toxin 2 (VT2), or Shiga-like toxin II (SLT-II) was purified from a cloned strain of Escherichia coli carrying a gene that encodes SLT-IIva, which is most closely related to SLT-IIv (VT2vp, VTe) in its nucleotide sequence. The purified SLT-IIva showed a slight difference from the purified SLT-IIv (VT2...

journal_title：Microbial pathogenesis

authors： Ohmura M,Cao C,Karasawa T,Okuda J,Kurazono H,Gannon VP,Gyles CL,Takeda Y

更新日期：1993-11-01 00:00:00

abstract：:The Gram-positive bacterium Group B Streptococcus (GBS) is an important cause of serious neonatal and adult infections. Toll-like receptor 2 (TLR2) recognizes components of the cell wall of Gram-positive bacteria and is critical for defense against certain invasive pathogens. In GBS, penicillin-binding protein 1a (PBP...

journal_title：Microbial pathogenesis

authors： Asplin IR,Carl DJ,Way SS,Jones AL

更新日期：2008-01-01 00:00:00

abstract：:Over the past 50 years, fungal natural products have revolutionized medicine, yielding drugs which have enormous therapeutic potential. The aim of this study was to investigate the probable effect of marine fungal natural products on various skin pathogens. Initially, seventy natural extracts obtained from 35 differen...

journal_title：Microbial pathogenesis

authors： Agrawal S,Barrow CJ,Deshmukh SK

更新日期：2020-09-01 00:00:00

abstract：:Salmonella is among the most important food borne pathogens worldwide contaminating a wide range of animal products including meat products. The aims of this study go through two steps: The first step is to estimate the proportion of sausages products contaminated with Salmonella in Meknes city (Morocco), which were c...

journal_title：Microbial pathogenesis

authors： Ed-Dra A,Filali FR,Karraouan B,El Allaoui A,Aboulkacem A,Bouchrif B

更新日期：2017-04-01 00:00:00

abstract：:This study aimed to isolate and demonstrate their antioxidant and immunostimulatory activities of potential probiotics. The isolated strains, S. Pum19, SC28, and SC61 showed potential probiotic properties including stability in artificial gastric and bile conditions, non-production of β-glucuronidase, suitable antibio...

journal_title：Microbial pathogenesis

authors： Son SH,Yang SJ,Jeon HL,Yu HS,Lee NK,Park YS,Paik HD

更新日期：2018-12-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy of 3'-deoxyadenosine and deoxycoformycin combination in the treatment of mice infected by T. cruzi, as well as to verify the influence of the treatment on purinergic enzymes. Heart and serum samples were collected from 60 mice (30 infected and 30 uninfected) at day 12...

journal_title：Microbial pathogenesis

authors： do Carmo GM,Doleski PH,de Sá MF,Grando TH,Azevedo MI,Manzoni AG,Leal DBR,Gressler LT,Henker LC,Mendes RE,Baldissera MD,Monteiro SG,Stefani LM,Da Silva AS

更新日期：2017-12-01 00:00:00

abstract：:Janthinobacterium sp. B9-8, isolated from low temperature-sewage in Xinjiang, China, is capable of producing violacein, a promising antibiotic. Here we report the genome sequence of B9-8, which consist of 4,726,850 bp with a G + C content of 48.72%. The violacein biosynthesis gene cluster vioABCDE was identified and a...

journal_title：Microbial pathogenesis

authors： Xu X,Tian L,Zhang S,Jiang L,Zhang Z,Huang H

更新日期：2019-03-01 00:00:00

abstract：:Toxoplasma gondii is an obligate intracellular parasite that is globally distributed and can infect almost all warm-blooded animals, including humans. While vaccines are not available for prophylaxis, there are limited therapeutic options which often do not result in eradication of parasites from patients. ME49 is a c...

journal_title：Microbial pathogenesis

authors： Ma Z,Mutashar Alhameed AM,Kaminga AC,Lu B,Li X,Zhang J,Wu X

更新日期：2020-03-01 00:00:00

abstract：:Bacillus anthracis secretes three major components, which assemble into two bipartite toxins: lethal toxin (LT), composed of lethal factor (LF) and protective antigen (PA) and edema toxin (ET), composed of edema factor (EF) and PA. EF is a potent calmodulin-dependent adenylate cyclase, which is internalized into the t...

journal_title：Microbial pathogenesis

authors： Levy H,Weiss S,Altboum Z,Schlomovitz J,Rothschild N,Glinert I,Sittner A,Kobiler D

更新日期：2012-01-01 00:00:00

abstract：:The live oral typhoid vaccine Ty21a has proved to confer protection against the disease at least as effectively as killed parenteral vaccines, whereas killed oral vaccines have not been protective in field trials. This prompted us to compare the immune response of subjects vaccinated either with live oral, killed oral...

journal_title：Microbial pathogenesis

authors： Kantele A,Arvilommi H,Kantele JM,Rintala L,Mäkelä PH

更新日期：1991-02-01 00:00:00

abstract：:Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, the most significant infectious bacterial disease of poultry worldwide. LuxS, the product of the luxS gene, mediates the quorum sensing (QS) mechanism. This involves the production of autoinducer-2 (AI-2), which regulates important physiological tra...

journal_title：Microbial pathogenesis

authors： Han X,Bai H,Liu L,Dong H,Liu R,Song J,Ding C,Qi K,Liu H,Yu S

更新日期：2013-02-01 00:00:00

abstract：:Identification of mycobacterial adhesins is needed to understand better the pathogenesis of tuberculosis and to develop new strategies to fight this infection. In this work, THP-1 monocytic cells were incubated with Mycobacterium tuberculosis culture filtrate proteins labelled with biotin and a dominant 19-kDa adhesin...

journal_title：Microbial pathogenesis

authors： Diaz-Silvestre H,Espinosa-Cueto P,Sanchez-Gonzalez A,Esparza-Ceron MA,Pereira-Suarez AL,Bernal-Fernandez G,Espitia C,Mancilla R

更新日期：2005-09-01 00:00:00

abstract：:We analyzed the complete genomic sequences of 17 porcine reproductive and respiratory syndrome virus (PRRSV) isolates from Southern China obtained between 2010 and 2011 and found that four of seven isolates from 2011 were closely related to the JXA1-R strain (vaccine virus of JXA1). This close relationship between fie...

journal_title：Microbial pathogenesis

authors： Zhang M,Xie J,Sun L,Cao Z,Gu H,Deng S,Chen Y,Cao Z,Tang F,Su S,Zhang G

更新日期：2013-12-01 00:00:00

abstract：:As a stationary-phase signal, indole is secreted in large quantities by Escherichia coli on enriched media and has been shown to control several genes; however, its impact on acid resistance remains to be studied in detail. Real-time quantitative reverse transcription-polymerase chain reaction analysis revealed that i...

journal_title：Microbial pathogenesis

authors： Hirakawa H,Hayashi-Nishino M,Yamaguchi A,Nishino K

更新日期：2010-09-01 00:00:00

abstract：:We have described a new class of live attenuated salmonella vaccines harbouring lesions in htrA, a stress protein gene previously. The virulence and invasiveness of Salmonella htrA mutants was investigated in three models of increased susceptibility to Salmonella infection. These included BALB/c mice, either given sub...

journal_title：Microbial pathogenesis

authors： Strahan K,Chatfield SN,Tite J,Dougan G,Hormaeche CE

更新日期：1992-04-01 00:00:00

abstract：:Inflammasome activation is an important host response to infectious diseases, but the difference in inflammasome activation between typhoid fever and non-typhoidal Salmonella infection has been rarely studied. To determine whether inflammasome activation in macrophages after S. Typhi and S. Typhimurium infection is di...

journal_title：Microbial pathogenesis

authors： Lin HH,Chen HL,Janapatla RP,Chen CL,Chiu CH

更新日期：2020-09-01 00:00:00

abstract：:This study was design to evaluate the physiological properties of bacteriophage-insensitive Klebsiella pneumoniae (BIKP) mutants in association with the antibiotic cross-resistance, β-lactamase activity, and gene expression. Klebsiella pneumoniae ATCC 23357(KPWT), ciprofloxacin-induced antibiotic-resistant K. pneumoni...

journal_title：Microbial pathogenesis

authors： Uddin MJ,Kim B,Dawan J,Ding T,Kim JC,Ahn J

更新日期：2019-10-01 00:00:00

abstract：:Pathogenic Salmonella strains have a set of virulence factors allowing them to generate systemic infections and damage in a variety of hosts. Among these factors, bacterial proteins secreted by specialized systems are used to penetrate the host's intestinal mucosa, through the invasion and destruction of specialized e...

journal_title：Microbial pathogenesis

authors： Varas M,Ortíz-Severín J,Marcoleta AE,Díaz-Pascual F,Allende ML,Santiviago CA,Chávez FP

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Cryptosporidiosis represents a major public health problem. This infection, caused by a protozoan parasite of the genus Cryptosporidium, has been reported worldwide as a frequent cause of diarrhoea. In the immunocompetent host, the typical watery diarrhea can be self-limiting. However, it is severe and chron...

journal_title：Microbial pathogenesis

authors： Chelbi H,Essid R,Jelassi R,Bouzekri N,Zidi I,Ben Salah H,Mrad I,Ben Sghaier I,Abdelmalek R,Aissa S,Bouratbine A,Aoun K

更新日期：2018-02-01 00:00:00

abstract：:Periodontitis is a highly prevalent infective and inflammatory disease with an adverse impact on systemic health. Isorhamnetin, a flavonoid mainly isolated from Hippophae fhamnoides L. fruit, has been reported to have anti-inflammatory effect. This study aimed to investigate the anti-inflammatory effects and mechanism...

journal_title：Microbial pathogenesis

authors： Qi F,Sun JH,Yan JQ,Li CM,Lv XC

更新日期：2018-07-01 00:00:00

abstract：:It was recently shown that, as in yeast, alcohols selectively increase the hemolytic properties of certain staphylococci strains. This phenomenon has been called 'microbial alcohol-conferred hemolysis'(MACH). Here we present the changes in gene expression by Staphylococcus aureus 8325-4, in response to ethanol. Ethano...

journal_title：Microbial pathogenesis

authors： Korem M,Gov Y,Rosenberg M

更新日期：2010-02-01 00:00:00

abstract：:Porphyromonas gingivalis is capable of in vitro growth when iron sources are either complexed to hemin or host iron transport proteins, or exist in an inorganic form. This study examined the effect of these iron sources on outer membrane protein (OMP) expression in P. gingivalis W50. Hemin (iron) starved P. gingivalis...

journal_title：Microbial pathogenesis

authors： Bramanti TE,Holt SC

更新日期：1992-07-01 00:00:00

abstract：:Actinobacillus pleuropneumoniae is the pathogen of porcine contagious pleuropneumonia causing great economic losses globally. LuxS is known to be involved in the interspecies quorum sensing by mediating the production of AI-2 signal molecule and play important roles in regulating various behaviors of bacteria. In this...

journal_title：Microbial pathogenesis

authors： Li L,Zhou R,Li T,Kang M,Wan Y,Xu Z,Chen H

更新日期：2008-09-01 00:00:00

abstract：:The hemA mutation reduces the virulence of Salmonella typhimurium for mice by at least 10(7)-fold, as measured by change in LD50. The hemA mutation does not appear to affect killing of salmonella in mice. The salmonella with the hemA mutation persist in the spleen and liver for 2 to 3 weeks following intravenous injec...

journal_title：Microbial pathogenesis

authors： Benjamin WH Jr,Hall P,Briles DE

更新日期：1991-10-01 00:00:00

abstract：:An inbred strain of the southern platyfish, Xiphophorus maculatus, was used as a host for Aeromonas hydrophila and Yersinia ruckeri infections. The infections were initiated by holding the platyfish in inoculation baths containing dilutions of virulent A. hydrophila or Y. ruckeri strains. Inoculating the platyfish in ...

journal_title：Microbial pathogenesis

authors： Kawula TH,Lelivelt MJ,Orndorff PE

更新日期：1996-02-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the most common opportunistic pathogens that cause biofilm-associated infections. Biofilm formation is partially regulated by the quorum sensing (QS) system, and quercetin can inhibit QS, biofilm formation and virulence factors. We therefore speculated that quercetin would inhibit the ...

journal_title：Microbial pathogenesis

authors： Ouyang J,Feng W,Lai X,Chen Y,Zhang X,Rong L,Sun F,Chen Y

更新日期：2020-12-01 00:00:00

abstract：:Bovine tuberculosis (bTB) is usually diagnosed in vivo and ex vivo on the basis of delayed hypersensitivity reactions with a complex pool of antigens named bovine tuberculin (PPDB). The IFN-γ release assay (IGRA) for bTB is a blood-based assay that improves detection of infected cattle at early stages that escape skin...

journal_title：Microbial pathogenesis

authors： Alvarez AH,Gutiérrez-Ortega A,Gómez-Entzin V,Pérez-Mayorga G,Naranjo-Bastién J,González-Martínez V,Milián-Suazo F,Martínez-Velázquez M,Herrera-Rodríguez S,Hinojoza-Loza E

更新日期：2017-07-01 00:00:00

abstract：:Vibrio cholerae, the agent of severe diarrheal disease cholera, is known to form biofilm to persist in the environmental and the host,s intestines. The bacteria execute a complex regulatory pathway producing virulence factors that allow colonization and cause disease in response to environmental signals in the intesti...

journal_title：Microbial pathogenesis

authors： Xi D,Yang S,Liu Q,Li Y,Li Y,Yan J,Wang X,Ning K,Cao B

更新日期：2020-07-01 00:00:00

abstract：:The prominent and phenotypically variable immunogenic protein of Trichomonas vaginalis, termed P270, is present in all isolates. Most, if not all, patients make antibody to the DREGRD epitope contained in the 333 bp tandemly repeating element (TRE). The complete sequence of p270 of a fresh clinical isolate was recentl...

journal_title：Microbial pathogenesis

authors： Musatovova O,Alderete JF

更新日期：1999-08-01 00:00:00

abstract：UNLABELLED:The outcome of Helicobacter pylori infection has been related to specific virulence-associated bacterial genotypes. The vacuolating cytotoxin (vacA), cagA gene, oipA and babA2 gene are important virulence factor involving gastric diseases. The objective of this study was to assess the relationship between vi...

journal_title：Microbial pathogenesis

authors： Salimzadeh L,Bagheri N,Zamanzad B,Azadegan-Dehkordi F,Rahimian G,Hashemzadeh-Chaleshtori M,Rafieian-Kopaei M,Sanei MH,Shirzad H

更新日期：2015-03-01 00:00:00