Abstract：
:Over the past 50 years, fungal natural products have revolutionized medicine, yielding drugs which have enormous therapeutic potential. The aim of this study was to investigate the probable effect of marine fungal natural products on various skin pathogens. Initially, seventy natural extracts obtained from 35 different marine fungal strains were analysed by the agar well diffusion and broth micro dilution assay for their antibacterial action against six human skin pathogens. The minimum inhibitory effects of all active fungal methanolic extracts on targeted pathogens were observed between 90 and 99% at the concentration of 1 mg/mL. The highest activity was recorded by fungal strains belonging to genera Penicillium, Emericellopsis and Simplicillium. Thereafter, possible effects on target bacterial cells were studied by scanning electron microscopy which show significant destruction and structural deformation in the bacterial cell wall. The results of the present study provided good evidence that the studied marine fungi can be a potential source of natural antibacterial agents against skin bacterial pathogens.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Agrawal S,Barrow CJ,Deshmukh SKdoi
10.1016/j.micpath.2020.104248subject
Has Abstractpub_date
2020-09-01 00:00:00pages
104248eissn
0882-4010issn
1096-1208pii
S0882-4010(20)30535-0journal_volume
146pub_type
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