Dysbiosis of gut microbiota in patients with esophageal cancer.


:A number of studies have identified that gut microbiota influences the development of cancer. However, there is little known about gut microbiota and esophageal cancer (EC). The aim of this study was to investigate the gut microbiota profile associated with EC. In this study, 23 patients with EC and 23 sex- and age-matched healthy controls (NC) were recruited between July 2019 and August 2019 at Huai'an First People's Hospital (Huai'an, China) and the gut microbiota was analyzed by 16S rRNA gene sequencing of fresh stool samples. We found that the microbial richness of intestinal flora in patients with EC were higher than NC, whereas evenness did not change obviously. Principal coordinate analysis (PCoA) and Unweighted Pair Group Method with Arithmetic Mean (UPGMA) analysis both revealed that a distinct separation in bacterial community composition between the EC and NC. At the phylum level, the EC group showed significantly higher abundances of Firmicutes and Actinobacteria, but a lower Bacteroidetes than NC. At the genus level, a significantly increased abundance of Streptococcus, Bifidobacterium, Subdoligranulum, Blautia, Romboutsia, Collinsella, Paeniclostridium, Dorea, and Atopobium were observed in EC patients, while Lachnospira, Bacteroides, Agathobacter, Lachnoclostridium, Parabacteroides, Paraprevotella, Butyricicoccus, Tyzzerella, Fusicatenibacter, and Sutterella were reduced. Receiver operating characteristic (ROC) analysis revealed that Lachnospira, Bacteroides, Streptococcus, and Bifidobacterium both achieved a high accuracy in EC diagnosis (area under the curve was more than 0.85), and the Lachnospira was found to be the best classifier. This study firstly characterized the gut microbiota composition of EC patients and screened out the optimal potential microbiota biomarkers for EC diagnosis. It may provide a fundamental reference for further studies on the gut microbiome for the diagnosis and treatment of EC.


Microb Pathog


Microbial pathogenesis


Deng Y,Tang D,Hou P,Shen W,Li H,Wang T,Liu R




Has Abstract


2020-12-27 00:00:00












  • Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant.

    abstract::Actinobacillus pleuropneumoniae is the pathogen of porcine contagious pleuropneumonia causing great economic losses globally. LuxS is known to be involved in the interspecies quorum sensing by mediating the production of AI-2 signal molecule and play important roles in regulating various behaviors of bacteria. In this...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Li L,Zhou R,Li T,Kang M,Wan Y,Xu Z,Chen H

    更新日期:2008-09-01 00:00:00

  • Elevated production of IL-36α in chronic hepatitis B virus-infected patients correlates with viral load.

    abstract::Chronic hepatitis B (CHB) infection is a typical inflammatory disease characterized by a dysregulated expression of cytokines, which contributes to the pathogenesis of chronic Hepatitis B virus (HBV) infection. IL-36 cytokines (IL-36α, IL-36β, IL-36γ and IL-36Ra) are important players in infection and immunity. Howeve...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Gong Y,Tingxi Z,Qing L,Guozhen Z,Bing T,Xiaoliang Y,Yan W,Wenjuan J,Yan X,Hui L,Xue H,Zebo Y

    更新日期:2017-12-01 00:00:00

  • Chemokine and cytokine production during Orientia tsutsugamushi infection in mice.

    abstract::Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus which is histopathologically characterized by inflammatory manifestations, indicating that rickettsiae induce mechanisms that amplify the inflammatory response. To understand the pathogenesis of scrub typhus, we examine...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Koh YS,Yun JH,Seong SY,Choi MS,Kim IS

    更新日期:2004-01-01 00:00:00

  • Antibiotic resistance, putative virulence factors and curli fimbrination among Cronobacter species.

    abstract::This study aimed to investigate antibiotic resistance and putative virulence factors among Cronobacter sakazakii isolated from powdered infant formula and other sources. The following 9 cultures (CR1-9) were collected from our culture collection: C. sakazakii and 3 Cronobacter species: C. sakazakii ATCC® 29544™, C. mu...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Odeyemi OA,Abdullah Sani N

    更新日期:2019-11-01 00:00:00

  • Complete genome sequence of Janthinobacterium sp. B9-8, a violacein-producing bacterium isolated from low-temperature sewage.

    abstract::Janthinobacterium sp. B9-8, isolated from low temperature-sewage in Xinjiang, China, is capable of producing violacein, a promising antibiotic. Here we report the genome sequence of B9-8, which consist of 4,726,850 bp with a G + C content of 48.72%. The violacein biosynthesis gene cluster vioABCDE was identified and a...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Xu X,Tian L,Zhang S,Jiang L,Zhang Z,Huang H

    更新日期:2019-03-01 00:00:00

  • Indole reduces the expression of virulence related genes in Vibrio splendidus pathogenic to sea cucumber Apostichopus japonicus.

    abstract::Indole is a metabolite of tryptophan that can be synthesized by various bacteria. In the present study, production of indole by Vibrio splendidus Vs was determined using Kovac's reagent, and m/z was further determined by HPLC-MS. Extracellular indole reached a maximum concentration of 160 μM, when OD600 of V. splendid...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Zhang S,Zhang W,Liu N,Song T,Liu H,Zhao X,Xu W,Li C

    更新日期:2017-10-01 00:00:00

  • Differential expression of structural and functional proteins during bean common mosaic virus-host plant interaction.

    abstract::Bean common mosaic virus (BCMV), the most common seed-borne pathogen in Phaseolus vulgaris L. is known to cause severe loss in productivity across the globe. In the present study, proteomic analyses were performed for leaf samples from control (healthy) and susceptible BCMV infected plants. The differential expression...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Kumar S,Dhembla C,P H,Sundd M,Patel AK

    更新日期:2020-01-01 00:00:00

  • Serum dependent expression of Enterococcus faecalis adhesins involved in the colonization of heart cells.

    abstract::Our previous studies have shown that the adhesive ability of Enterococcus faecalis is dependent on the strain and is further modified by growth in serum. The data reported here demonstrate that E. faecalis adherence is mediated by carbohydrate residues present on the bacterial cell surface. Some of these (D-mannose an...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Guzmàn CA,Pruzzo C,Platè M,Guardati MC,Calegari L

    更新日期:1991-12-01 00:00:00

  • Multiple-locus variable-number tandem repeat analysis (MLVA) for genotyping of Salmonella enterica subspecies enterica serotype Infantis isolated from human sources.

    abstract::Salmonella is an important cause of food-borne infection worldwide. Detection of outbreaks caused by Salmonella spp. relies on suitable and robust methods for genotyping. Little is known about the genetic diversity of the Salmonella enterica subspecies enterica serotype Infantis strains isolated from human sources in ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Ranjbar R,Ahmadi M,Memariani M

    更新日期:2016-11-01 00:00:00

  • Worldwide prevalence of emerging parasite Blastocystis in immunocompromised patients: A systematic review and meta-analysis.

    abstract:BACKGROUND:Blastocystis is one of the most common pathogens of the human intestine, caused by an emerging parasite, which can lead to severe symptoms and even death in immunocompromised patients. We aimed to determine the global prevalence of Blastocystosis infection in people with immunodeficiency. A systematic litera...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Khorshidvand Z,Khazaei S,Amiri M,Taherkhani H,Mirzaei A

    更新日期:2020-11-24 00:00:00

  • Molecular-genetic peculiarities of classical biotype Vibrio cholerae, the etiological agent of the last outbreak Asiatic cholera in Russia.

    abstract::Molecular-genetic properties of classical biotype Vibrio cholerae strains that caused the Asiatic cholera outbreak in 1942 in Russia have been investigated for the first time. Being characterized by high-level production of cholera toxin and toxin-coregulated adhesion pili both of which are the major virulence factors...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Smirnova NI,Cheldyshova NB,Zadnova SP,Kutyrev VV

    更新日期:2004-03-01 00:00:00

  • Bioinformatics of excretory/secretory proteins of Toxoplasma gondii strain ME49.

    abstract::Toxoplasma gondii is an obligate intracellular parasite that is globally distributed and can infect almost all warm-blooded animals, including humans. While vaccines are not available for prophylaxis, there are limited therapeutic options which often do not result in eradication of parasites from patients. ME49 is a c...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Ma Z,Mutashar Alhameed AM,Kaminga AC,Lu B,Li X,Zhang J,Wu X

    更新日期:2020-03-01 00:00:00

  • Chlamydia pneumoniae facilitates monocyte adhesion to endothelial and smooth muscle cells.

    abstract::Chlamydia pneumoniae has been linked to atherosclerotic heart disease. However, there is a limited knowledge by which C. pneumoniae gain access to atheromatous lesions. The adhesion of C. pneumoniae -infected circulatory component(s) to endothelium and smooth muscle cells represents the first step in an inflammatory r...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Kaul R,Wenman WM

    更新日期:2001-03-01 00:00:00

  • Recombinant ubiquitin-conjugating enzyme of Eimeria maxima induces immunogenic maturation in chicken splenic-derived dendritic cells and drives Th1 polarization in-vitro.

    abstract::Dendritic cells (DCs) are key linkages between innate immunity and acquired immunity. The antigens that promote the functions of DCs might be the effective candidates of novel vaccine. In this research, the ability of ubiquitin-conjugating enzyme (UCE), a recognized common antigens among chicken Eimeria species, to st...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Lakho SA,Haseeb M,Huang J,Hasan MW,Naqvi MA,Zhou Z,Song X,Yan R,Xu L,Li X

    更新日期:2020-06-01 00:00:00

  • New Phage cocktail against infantile Sepsis bacteria.

    abstract::A total of 54 positive blood aerobic cultures of suspected blood sepsis in neonates were purified, diagnosed and tested for antibiotic susceptibility. Six bacterial pathogens of Escherichia coli (10 isolates), Klebsiella pneumoniae (10 isolates), Haemophilus influenzae (4 isolates), Pseudomonas aeruginosa (3 isolates)...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Gatea Kaabi SA,Musafer HK

    更新日期:2020-11-01 00:00:00

  • Antioxidant defense response induced by Trichoderma viride against Aspergillus niger Van Tieghem causing collar rot in groundnut (Arachis hypogaea L.).

    abstract::The study was conducted to examine the antioxidant enzymes induced by Trichoderma viride JAU60 as initial defense response during invasion of rot pathogen Aspergillus niger Van Tieghem in five groundnut varieties under pot culture. Seed treatment of T. viride JAU60 reduced 51-58% collar rot disease incidence in differ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Gajera HP,Katakpara ZA,Patel SV,Golakiya BA

    更新日期:2016-02-01 00:00:00

  • Binding of enterotoxigenic Escherichia coli to isolated enterocytes and intestinal mucus.

    abstract::Binding of human enterotoxigenic Escherichia coli (ETEC) to the small intestine is a prerequisite for colonization and is mediated by colonization factor (CF) antigens. Coli surface antigen 6 (CS6) is considered a CF but binding to isolated enterocytes has not been established. In this study bacteria expressing CS6 we...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Helander A,Hansson GC,Svennerholm AM

    更新日期:1997-12-01 00:00:00

  • Rational selection of broadly cross-reactive family 2 PspA molecules for inclusion in chimeric pneumococcal vaccines.

    abstract::Pneumococcal surface protein A (PspA) is a widely studied pneumococcal protein, exposed at the surface of all strains. It is an important virulence factor, preventing complement deposition as well as inhibiting the lytic effects of lactoferrin over pneumococci. Several studies have investigated the use of PspA as a ca...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Converso TR,Goulart C,Rodriguez D,Darrieux M,Leite LCC

    更新日期:2017-08-01 00:00:00

  • Assessment of antigenic supplementation of bovine purified protein derivative for diagnosis of subclinical infection with Mycobacterium bovis in cattle.

    abstract::Bovine tuberculosis (bTB) is usually diagnosed in vivo and ex vivo on the basis of delayed hypersensitivity reactions with a complex pool of antigens named bovine tuberculin (PPDB). The IFN-γ release assay (IGRA) for bTB is a blood-based assay that improves detection of infected cattle at early stages that escape skin...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Alvarez AH,Gutiérrez-Ortega A,Gómez-Entzin V,Pérez-Mayorga G,Naranjo-Bastién J,González-Martínez V,Milián-Suazo F,Martínez-Velázquez M,Herrera-Rodríguez S,Hinojoza-Loza E

    更新日期:2017-07-01 00:00:00

  • Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response.

    abstract::In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both e...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Penttilä T,Haveri A,Tammiruusu A,Vuola JM,Lahesmaa R,Puolakkainen M

    更新日期:2008-07-01 00:00:00

  • Deletion in the 190 kDa antigen gene repeat region of Rickettsia rickettsii.

    abstract::The 190 kDa outer membrane protein of Rickettsia rickettsii is a major immunodominant protective antigen which contains 13 tandem nearly identical repeating sequences. We have identified a deletion in the 190 kDa antigen gene of R. rickettsii strain Smith maintained in the laboratory. The deletion occurred within the ...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Matsumoto M,Tange Y,Okada T,Inoue Y,Horiuchi T,Kobayashi Y,Fujita S

    更新日期:1996-01-01 00:00:00

  • In-silico designing, chemical synthesis, characterization and in-vitro assessment of antibacterial properties of some analogues of curcumin.

    abstract::In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder molecule from the spice turmeric and structures of its twelve analogues were designed, synthesized and tested i...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Shrivash MK,Mishra S,UpmaNarain,Pandey J,Misra K

    更新日期:2018-10-01 00:00:00

  • Antibacterial substances produced by pathogen inhibitory gut bacteria in Labeo rohita: Physico-chemical characterization, purification and identification through MALDI-TOF mass spectrometry.

    abstract::Application of antibiotics to combat bacterial diseases in fish has been criticized due to likely emergence of drug resistance. Therefore, investigation of new bioactive compounds from natural sources has been taken into account. This study was designed to purify and characterize the bioactive compound in the cell fre...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Mukherjee A,Banerjee G,Mukherjee P,Ray AK,Chandra G,Ghosh K

    更新日期:2019-05-01 00:00:00

  • Comparison of the human immune response to live oral, killed oral or killed parenteral Salmonella typhi TY21A vaccines.

    abstract::The live oral typhoid vaccine Ty21a has proved to confer protection against the disease at least as effectively as killed parenteral vaccines, whereas killed oral vaccines have not been protective in field trials. This prompted us to compare the immune response of subjects vaccinated either with live oral, killed oral...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Kantele A,Arvilommi H,Kantele JM,Rintala L,Mäkelä PH

    更新日期:1991-02-01 00:00:00

  • Expression of the Escherichia coli lamB gene in Vibrio cholerae.

    abstract::A phage lambda mediated transduction system was devised to facilitate molecular analysis of Vibrio cholerae. A lamB expression plasmid, pAMH62 was introduced into Vibrio cholerae by conjugation. The resulting V. cholerae derivatives harboring pAMH62 produced substantial amounts of the LamB protein. This protein was pr...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Harkki A,Hirst TR,Holmgren J,Palva ET

    更新日期:1986-06-01 00:00:00

  • Low-dose doxycycline induces Chlamydia trachomatis persistence in HeLa cells.

    abstract::Chlamydia persistence is a viable but non-replicative stage, induced by several sub-lethal stressor agents, including beta-lactam antibiotics. So far, no data about the connection between doxycycline and chlamydial persistence has been described in literature. We investigated the ability of doxycycline to induce C. tr...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Marangoni A,Zalambani C,Marziali G,Salvo M,Fato R,Foschi C,Re MC

    更新日期:2020-10-01 00:00:00

  • Intra-amoebal killing of Mycobacterium ulcerans by Acanthamoeba griffini: A co-culture model.

    abstract::Mycobacterium ulcerans, a decaying Mycobacterium marinum derivative is responsible for Buruli ulcer, a notifiable non-contagious disabling infection highly prevalent in some West African countries. Aquatic environments are suspected to host M. ulcerans, however, the exact reservoirs remain unknown. While M. marinum wa...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Bouam A,Ghigo E,Drancourt M

    更新日期:2018-01-01 00:00:00

  • Potentiation of antibiotic activity of aminoglycosides by natural products from Cordia verbenacea DC.

    abstract::Medicinal plants are often the only therapeutic resource for many communities and ethnic groups. Cordia verbenacea DC., "Erva-baleeira," is one of the species of plants currently used to produce a phytotherapeutic product extracted from its leaves. The present study aimed to establish its chemical profile, antibacteri...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Matias EFF,Alves EF,Silva MKN,Carvalho VRA,Medeiros CR,Santos FAV,Bitu VCN,Souza CES,Figueredo FG,Boligon AA,Athayde ML,Costa JGM,Coutinho HDM

    更新日期:2016-06-01 00:00:00

  • Deep sequencing-based expression transcriptional profiling changes during Brucella infection.

    abstract::Brucellosis is a worldwide zoonotic infectious disease that has significant economic effects on animal production and human health. The host macrophage -Brucella interaction is critical to the establishment of infections. Thus, the kinetic transcriptional profile of gene expression in macrophages infected with the Bru...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Liu Q,Han W,Sun C,Zhou L,Ma L,Lei L,Yan S,Liu S,Du C,Feng X

    更新日期:2012-05-01 00:00:00

  • Indole enhances acid resistance in Escherichia coli.

    abstract::As a stationary-phase signal, indole is secreted in large quantities by Escherichia coli on enriched media and has been shown to control several genes; however, its impact on acid resistance remains to be studied in detail. Real-time quantitative reverse transcription-polymerase chain reaction analysis revealed that i...

    journal_title:Microbial pathogenesis

    pub_type: 杂志文章


    authors: Hirakawa H,Hayashi-Nishino M,Yamaguchi A,Nishino K

    更新日期:2010-09-01 00:00:00