Abstract：
:Pathogenic Salmonella strains have a set of virulence factors allowing them to generate systemic infections and damage in a variety of hosts. Among these factors, bacterial proteins secreted by specialized systems are used to penetrate the host's intestinal mucosa, through the invasion and destruction of specialized epithelial M cells in the intestine. On the other hand, numerous studies have demonstrated that humans, as well as experimental animal hosts, respond to Salmonella infection by activating both innate and adaptive immune responses. Here, through live cell imaging of S. Typhimurium infection of zebrafish larvae, we showed that besides the intestinal colonization, a deformed cloacae region and a concomitant accumulation of S. Typhimurium cells was observed upon bacterial infection. The swelling led to a persistent inflammation of infected larvae, although the infection was non-lethal. The in vivo inflammation process was confirmed by the co-localization of GFP-tagged S. Typhimurium with mCherry-tagged neutrophils at 72 h post exposition. Our live-cell analyses suggest that Salmonella Typhimurium induce cloacitis-like symptoms in zebrafish larvae.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Varas M,Ortíz-Severín J,Marcoleta AE,Díaz-Pascual F,Allende ML,Santiviago CA,Chávez FPdoi
10.1016/j.micpath.2017.04.010subject
Has Abstractpub_date
2017-06-01 00:00:00pages
317-320eissn
0882-4010issn
1096-1208pii
S0882-4010(17)30211-5journal_volume
107pub_type
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更新日期：2016-12-01 00:00:00
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更新日期：2018-06-01 00:00:00
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更新日期：2017-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-05-01 00:00:00
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journal_title：Microbial pathogenesis
pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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更新日期：2000-07-01 00:00:00
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doi：10.1016/j.micpath.2018.12.011
更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-07-01 00:00:00
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更新日期：2019-09-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2020-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2019-12-01 00:00:00
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更新日期：1989-03-01 00:00:00
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更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
abstract：:Capnocytophaga canimorsus is a part of healthy oral flora of dogs and cats. However, when it is transmitted to human subjects via animal bites or scratches, it can cause severe complications like endocarditis or even lethal septic shock, especially in immunocompromised persons. In this study, we performed the first wh...
journal_title：Microbial pathogenesis
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更新日期：2018-12-01 00:00:00
