Abstract:
:β-1,3-glucan plays a role in non-albicans Candida species biofilm formation and survival of biofilm Candida to stresses. In this study, we evaluated the antibiofilm activity of β-1,3-glucanase, which can degrade poly-β(1 → 3)-glucose of non-albicans Candida species biofilms, on single and mixed species biofilm of non-albicans Candida species, including Candida tropicalis, Candida parapsilosis and Candida krusei. Biofilm by all tested species in microplate were dispersed more than 60%. β-1,3-glucanase also detached mixed species biofilm in microplate and on medical material surface. β-1,3-glucanase had no effect on Candida planktonic growth as well as adhesion. However, further biofilm formation was inhibited with β-1,3-glucanase added at 24 h after biofilm initiation. β-1,3-glucanase markedly enhanced the antifungal susceptibility of amphotericin B. The examination using confocal laser scanning microscopy and scanning electron microscope confirmed the antibiofilm activity of β-1,3-glucanase. Our findings demonstrate that β-1,3-glucanase may be useful as an antibiofilm agent.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Tan Y,Leonhard M,Ma S,Moser D,Schneider-Stickler Bdoi
10.1016/j.micpath.2017.10.057subject
Has Abstractpub_date
2017-12-01 00:00:00pages
342-347eissn
0882-4010issn
1096-1208pii
S0882-4010(17)30829-Xjournal_volume
113pub_type
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