Role of H-2 and non-H-2-related genes in mouse susceptibility to Chlamydia psittaci.

Abstract:

:The genetic control of mouse susceptibility to Chlamydia psittaci was investigated after intravenous inoculation of 2 x 10(5) plaque-forming units (pfu). Splenic counts 6 days after inoculation gave the level of susceptibility. Results from inoculation of mice from H-2 congenic strains with three different genetic backgrounds (B10, BALB and C3H) suggested that both the non-H-2 genes and the genes of H-2 complex or those closely associated with it, were responsible for the observed differences in the innate capacity of various inbred lines of mice to control bacterial load in their infected organs following a challenge with C. psittaci.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Buzoni-Gatel D,Bernard F,Pla M,Rodolakis A,Lantier F

doi

10.1006/mpat.1994.1023

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

229-33

issue

3

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(84)71023-0

journal_volume

16

pub_type

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