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Gene expression signatures characterizing the development of lymphocyte response during experimental Chlamydia pneumoniae infection.

Abstract：

:In this study experimental mouse model for Chlamydia pneumoniae infection was used to elucidate the nature of immune response developing during primary and secondary infection. First we examined the mononuclear cells from different lymphoid organs in BALB/c mice during C. pneumoniae infection and detected a strong lymphocyte influx into mediastinal lymph nodes (MLN). To further characterize the C. pneumoniae induced immune response the gene expression profiles of MLN derived lymphocytes was studied. To identify genes characteristic for reinfection we compared gene expression profiles during reinfection and primary infection and found 148 genes to be differentially regulated in CD19+ cells, 7 in CD4+ cells and 12 in CD8+ cells. A panel of these genes was selected to be confirmed by real-time RT-PCR. Genes related to interferon signaling like Ifit1, Ifit3, Gbp2, Irf7 and Usp18 were found to be upregulated when reinfection was compared to primary infection. In our study we were able to identify 8 genes that were differentially expressed between reinfection and primary infection in lymphocytes. These novel gene expression signatures provide new insights and clues to the nature of protective immunity established during experimental C. pneumoniae immunity.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Kyläniemi MK,Haveri A,Vuola JM,Puolakkainen M,Lahesmaa R

doi

10.1016/j.micpath.2009.01.006

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

235-42

issue

5

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(09)00018-7

journal_volume

46

pub_type

杂志文章

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