Abstract:
:We analyzed here the complete genome sequences of a highly virulent Flavobacterium columnare Pf1 strain isolated in our laboratory. The complete genome consists of a 3,171,081 bp circular DNA with 2784 predicted protein-coding genes. Among these, 286 genes were predicted as antibiotic resistance genes, including 32 RND-type efflux pump related genes which were associated with the export of aminoglycosides, indicating inducible aminoglycosides resistances in F. columnare. On the other hand, 328 genes were predicted as pathogenicity related genes which could be classified as virulence factors, gliding motility proteins, adhesins, and many putative secreted proteases. These genes were probably involved in the colonization, invasion and destruction of fish tissues during the infection of F. columnare. Apparently, our obtained complete genome sequences provide the basis for the explanation of the interactions between the F. columnare and the infected fish. The predicted antibiotic resistance and pathogenicity related genes will shed a new light on the development of more efficient preventional strategies against the infection of F. columnare, which is a major worldwide fish pathogen.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Zhang Y,Zhao L,Chen W,Huang Y,Yang L,Sarathbabu V,Wu Z,Li J,Nie P,Lin Ldoi
10.1016/j.micpath.2017.08.035subject
Has Abstractpub_date
2017-10-01 00:00:00pages
203-211eissn
0882-4010issn
1096-1208pii
S0882-4010(17)30962-2journal_volume
111pub_type
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