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Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus).

Abstract：

:The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman primates, wild rodents and mosquitoes as well as mice used as sentinels. The virus is able to cause febrile disease in humans. Here we describe for the first time pathologic and biochemical findings in golden hamsters (Mesocricetus auratus) infected with the prototype GMAV. Blood and organs of infected and control animals were collected every 24 h after infection from the 1st to the 7th day post infection (dpi) and at 21 dpi when experiment was ended. The tissues were processed for histopathology and immunohistochemistry. The blood and serum were used to determine viremia and biochemical markers plus to detect anti-GMAV antibodies. The viremia was early detected already on the 1st dpi and it was no longer detected on the 3rd dpi. Total anti-GMAV antibodies were detected from the 6th dpi. Hepatic markers as ALT of infected animals were increased and showed statistically significant difference in comparison with control animals, indicating damage of the liver; indeed the liver was the most affected organ, but other organs presented lesions and positive GMAV immunostaining as brain, lung, liver, spleen, and kidney. Our findings indicate that golden hamsters are a good animal model for experimental infection of the GMAV.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Matos GC,Ferreira MS,Martins Filho AJ,Amador Neto OP,Campos VM,Lima MLG,Rodrigues JCP,Ribeiro ACDS,Freitas MNO,Silva FA,Chiang JO,Casseb LMN,Sousa JR,Quaresma JAS,Martins LC,Vasconcelos PFDC,Carvalho VL

doi

10.1016/j.micpath.2019.103627

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

103627

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(19)30439-5

journal_volume

135

pub_type

杂志文章

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