Inhibition of TLR8 mediated signaling promotes BCG induced apoptosis in THP-1 cells.

abstract：BACKGROUND:Obesity is associated with alteration of the gut microbiota. In order to clarify the effect of Lactobacillus-containing probiotics (LCP) on weight we performed a meta-analysis of clinical studies and experimental models. We intended to assess effects by Lactobacillus species. METHODS:A broad search with no ...

journal_title：Microbial pathogenesis

authors： Million M,Angelakis E,Paul M,Armougom F,Leibovici L,Raoult D

更新日期：2012-08-01 00:00:00

abstract：:The initiation of many infectious diseases involves specific adhesion of bacteria to host tissue proteins and carbohydrates. Staphylococcus aureus is known to bind specifically to several proteins in the extracellular matrix (ECM). We report the quantification of the collagen and fibronectin adhesin densities on the s...

journal_title：Microbial pathogenesis

authors： Mohamed N,Visai L,Speziale P,Ross JM

更新日期：2000-12-01 00:00:00

abstract：:Heat-stable enterotoxins (ST) activate guanylyl cyclase in T84 cells, rapidly and specifically. Activation is monitored by cGMP production and occurs at lower concentrations of ST than required for eliciting fluid accumulation in suckling mice. Atrial natriuretic factor (ANF) neither activates guanylyl cyclase nor mod...

journal_title：Microbial pathogenesis

authors： Visweswariah SS,Shanthi G,Balganesh TS

更新日期：1992-03-01 00:00:00

abstract：:Neisseria meningitidis is normally a human nasopharyngeal commensal but is also capable of causing life-threatening sepsis and meningitis. N. meningitidis secretes several virulence-associated proteins including Neisserial autotransporter lipoprotein (NalP), an immunogenic, type Va autotransporter harboring an S8-fami...

journal_title：Microbial pathogenesis

authors： Dufailu OA,Mahdavi J,Ala'Aldeen DAA,Wooldridge KG,Oldfield NJ

更新日期：2018-11-01 00:00:00

abstract：:Phenotypic serum resistance of gonococci in urethral exudates is due to sialylation of lipopolysaccharide (LPS) by host cytidine 5'-monophospho-N-acetyl neuraminic acid (CMP-NANA). A surface structure was visible on gonococci [strain BS4 (agar)] that had been stained with ruthenium red after incubation with CMP-NANA. ...

journal_title：Microbial pathogenesis

authors： Fox AJ,Curry A,Jones DM,Demarco de Hormaeche R,Parsons NJ,Cole JA,Smith H

更新日期：1991-09-01 00:00:00

abstract：:Mycoplasma hyopneumoniae is the etiological agent of enzootic pneumonia (EP), a widespread disease that causes major economic losses to the pig industry. The swine host response plays an important role in the outcome of M. hyopneumoniae infections. The whole proteome of newborn pig trachea (NPTr) epithelial cells infe...

journal_title：Microbial pathogenesis

authors： Leal Zimmer FMA,Moura H,Barr JR,Ferreira HB

更新日期：2019-12-01 00:00:00

abstract：:Group G streptococci have on their surface antiphagocytic M protein-like antigens. To determine if these organisms have genes similar to the M protein genes of Streptococcus pyogenes (group A), DNA from independent group G isolates of human and animal origin were tested for homology to probes representing sequences en...

journal_title：Microbial pathogenesis

authors： Simpson WJ,Robbins JC,Cleary PP

更新日期：1987-11-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the most common opportunistic pathogens that cause biofilm-associated infections. Biofilm formation is partially regulated by the quorum sensing (QS) system, and quercetin can inhibit QS, biofilm formation and virulence factors. We therefore speculated that quercetin would inhibit the ...

journal_title：Microbial pathogenesis

authors： Ouyang J,Feng W,Lai X,Chen Y,Zhang X,Rong L,Sun F,Chen Y

更新日期：2020-12-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a neutrophil and T-lymphocyte chemotactic and activating factor. This cytokine is produced by many cell types including macrophages in response to a variety of microbial and non-microbial agents. In the present study, we determined the nucleotide sequence for bovine IL-8 cDNA. The amino acid se...

journal_title：Microbial pathogenesis

authors： Morsey MA,Popowych Y,Kowalski J,Gerlach G,Godson D,Campos M,Babiuk LA

更新日期：1996-04-01 00:00:00

abstract：:Mycoplasma bovis is a risky pathogen mainly responsible for pneumonia and mastitis in cattle. Up to date, its pathogenesis is not clear. Since secreted proteins have a tricky role in M. bovis pathogenesis, this study was designed to systematically reveal M. bovis secretome and potential role in virulence of the pathog...

journal_title：Microbial pathogenesis

authors： Zubair M,Muhamed SA,Khan FA,Zhao G,Menghwar H,Faisal M,Zhang H,Zhu X,Rasheed MA,Chen Y,Marawan MA,Chen H,Guo A

更新日期：2020-06-01 00:00:00

abstract：:An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by insertional mutagenesis, and the MdaB protein was purified and compared to the Helicobacter pylori enzyme. While wild type H. hepaticus cells could tolerate 6% O(2) for growth, the mdaB strain was cle...

journal_title：Microbial pathogenesis

authors： Hong Y,Wang G,Maier RJ

更新日期：2008-02-01 00:00:00

abstract：:A DNA fragment encoding an approximately 18 kDa protein from Brucella abortus strain 2308 was cloned and expressed in Escherichia coli. This recombinant protein, designated BA18K, reacted in Western blot analysis with sera obtained from experimentally and naturally infected animals including mice, goats, dogs and huma...

journal_title：Microbial pathogenesis

authors： Kovach ME,Elzer PH,Robertson GT,Chirhart-Gilleland RL,Christensen MA,Peterson KM,Roop RM 2nd

更新日期：1997-04-01 00:00:00

abstract：:In order to characterize the toxicity of the hemorrhagic toxin of Clostridium sporogenes isolated from the rabbit with antibiotic-associated hemorrhagic diarrhoea, we studied the toxin productivity of C. sporogenes cultured in various media and the toxic effect of the partially purified preparation of the culture supe...

journal_title：Microbial pathogenesis

authors： Hara-Kudo Y,Ogura A,Noguchi Y,Terao K,Kumagai S

更新日期：1997-01-01 00:00:00

abstract：:Molecular prevalence of nine putative virulence factors in two more prevalent Brucella species in Iranian patients and livestock was investigated. During five years (2010-2015), 120 human and animal specimens were collected from three geographical areas of Iran. All samples were cultured in blood culture media and sub...

journal_title：Microbial pathogenesis

authors： Hashemifar I,Yadegar A,Jazi FM,Amirmozafari N

更新日期：2017-04-01 00:00:00

abstract：:We obtained biologically active purified leukotoxin (Lkt) from Pasteurella haemolytica serotypel, strain 12296 using preparative sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Three species of Lkt of molecular masses 95, 100, and 104 kDa were obtained. Purity of all three species of Lkt was conf...

journal_title：Microbial pathogenesis

authors： Yoo HS,Rajagopal BS,Maheswaran SK,Ames TR

更新日期：1995-04-01 00:00:00

abstract：:In this study, the effects of water, ethanol, methanol and glycerin at five levels (0, 31.25, 83.33, 125 and 250 ml) were investigated on the efficiency of mangrove leaf extraction using mixture optimal design. The antimicrobial effect of the extracts on Streptococcus pneumoniae, Enterococcus faecium and Klebsiella pn...

journal_title：Microbial pathogenesis

authors： Alizadeh Behbahani B,Tabatabaei Yazdi F,Shahidi F,Noorbakhsh H,Vasiee A,Alghooneh A

更新日期：2018-01-01 00:00:00

abstract：:CpG DNA is a potent activator of the innate immune system. Here the protective effects of CpG DNA are assessed against the facultative intracellular pathogen Francisella tularensis. Dosing of mice with CpG DNA provided protection against disease caused by F. tularensis subsp. holarctica live vaccine strain (LVS) but d...

journal_title：Microbial pathogenesis

authors： Rees DG,Hartley MG,Green M,Lukaszewski RA,Griffin KF,Atkins HS,Lyons R,Krieg AM,Titball RW

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Host factors such as hormones are known to modulate growth, virulence and antibiotic susceptibility of bacteria. In the present study, the effect of norepinephrine (NE) and estradiol (Est) on growth and expression levels of virulence genes (usp, sfa/foc, cnf1, aer) of uropathogenic E. coli (UPEC) strains C7 ...

journal_title：Microbial pathogenesis

authors： Gümüş D,Kalaycı Yüksek F,Sefer Ö,Yörük E,Uz G,Anğ Küçüker M

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Tuberculosis (TB) remains a major public health problem. SH3RF1 and SH3RF2 are candidate genes with multiple single-nucleotide polymorphisms (SNPs) that have the potential to participate in Mycobacterium infection via activation of the JNK signaling pathway. In this case-control study, we aimed to investigat...

journal_title：Microbial pathogenesis

authors： Chen H,Zhou J,Jiao L,Song J,Zhong H,Zhao Z,Meng Z,Lu X,Chen X,Zhang W,Ying B

更新日期：2020-10-28 00:00:00

abstract：:In this study an attempt to address the effects of immunosuppression on pathogenesis of peste des petits ruminants (PPR) virus infection was undertaken. Cyclophosphamide and dexamethasone were used to immunosuppress the animals. The drug treated animals exhibited severe leukopaenia and lymphopaenia; one of the indicat...

journal_title：Microbial pathogenesis

authors： Jagtap SP,Rajak KK,Garg UK,Sen A,Bhanuprakash V,Sudhakar SB,Balamurugan V,Patel A,Ahuja A,Singh RK,Vanamayya PR

更新日期：2012-04-01 00:00:00

abstract：:Our previous studies have shown that the adhesive ability of Enterococcus faecalis is dependent on the strain and is further modified by growth in serum. The data reported here demonstrate that E. faecalis adherence is mediated by carbohydrate residues present on the bacterial cell surface. Some of these (D-mannose an...

journal_title：Microbial pathogenesis

authors： Guzmàn CA,Pruzzo C,Platè M,Guardati MC,Calegari L

更新日期：1991-12-01 00:00:00

abstract：:Essential oils and their chemical constituents have been reported with well documented antimicrobial effects against a range of bacterial, fungal and viral pathogens. By definition, essential oils are a complex mixture of volatile organic compounds which are synthesized naturally in different parts of the plant as par...

journal_title：Microbial pathogenesis

authors： Wani AR,Yadav K,Khursheed A,Rather MA

更新日期：2020-11-16 00:00:00

abstract：:Lack of a system for genetic manipulation of Chlamydia trachomatis has been a key challenge to advancing understanding the molecular genetic basis of virulence for this bacterial pathogen. We developed a non-viral, dendrimer-enabled system for transformation of this organism and used it to characterize the effects of ...

journal_title：Microbial pathogenesis

authors： Kannan RM,Gérard HC,Mishra MK,Mao G,Wang S,Hali M,Whittum-Hudson JA,Hudson AP

更新日期：2013-12-01 00:00:00

abstract：:Streptokinase (SK), a heterogeneous plasminogen (Pg) activator protein secreted by groups A, C and G streptococci (GAS/GCS/GGS) is a virulence factor composed of three structural domains; SKα/SKβ/SKγ. Phylogenetic analysis of the major variable region of SKβ (sk-V1; nucleotides 448-791; 343bp) which classifies the SK ...

journal_title：Microbial pathogenesis

authors： Keramati M,Aslani MM,Roohvand F

更新日期：2020-02-01 00:00:00

abstract：:The pathogenesis and development of ankylosing spondylitis (AS) is concealed and complicated. In recent years, alterations in gut microbiota of AS patients have been largely investigated, although the underlying mechanisms remain unclear. This article reviews the recent studies on changes of gut microbiota in AS patie...

journal_title：Microbial pathogenesis

authors： Zhang L,Hu Y,Xu Y,Li P,Ma H,Li X,Li M

更新日期：2019-07-01 00:00:00

abstract：:The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman primates, wild rodents and mosquitoes as well as mice used as sentinels. The virus is able ...

journal_title：Microbial pathogenesis

authors： Matos GC,Ferreira MS,Martins Filho AJ,Amador Neto OP,Campos VM,Lima MLG,Rodrigues JCP,Ribeiro ACDS,Freitas MNO,Silva FA,Chiang JO,Casseb LMN,Sousa JR,Quaresma JAS,Martins LC,Vasconcelos PFDC,Carvalho VL

更新日期：2019-10-01 00:00:00

abstract：:A common feature of many chlamydial infections is that they are often asymptomatic and may persist for long periods of time if left untreated. In addition to the well recognized lytic stage of the chlamydial developmental cycle, evidence is now emerging to support a persistent phase in the cycle in which the reticulat...

journal_title：Microbial pathogenesis

authors： Mathews S,George C,Flegg C,Stenzel D,Timms P

更新日期：2001-06-01 00:00:00

abstract：:The extracellular hemolysin (AHH1) gene of Aeromonas hydrophila ATCC7966 was cloned into Charomid9-28 in Escherichia coli DH1, and its complete nucleotide sequence determined. Escherichia coli carrying this gene expressed an extracellular heat-labile hemolysin for rabbit red blood cells. The minimum size of the coding...

journal_title：Microbial pathogenesis

authors： Hirono I,Aoki T

更新日期：1991-09-01 00:00:00

abstract：:The corticosteroid-treated animal is well established as an experimental model for the study of Pneumocystis carinii pneumonitis (PCP). Latent or acquired infection with P. carinii in the murine lung progresses to fatal pneumonitis when the host is profoundly immunocompromized. In this study the effects of five immuno...

journal_title：Microbial pathogenesis

authors： Oz HS,Hughes WT,Rehg JE,Thomas EK

更新日期：2000-09-01 00:00:00

abstract：:Tick-borne bacteria are considered to be emerging in camels, but data about their occurrence in Tunisian dromedaries and their infesting ticks remain scarce. In this study, 412 camel blood samples and 327 partially engorged ticks were collected and tested for the presence of Coxiella burnetii and/or related strains, a...

journal_title：Microbial pathogenesis

authors： Selmi R,Ben Said M,Mamlouk A,Ben Yahia H,Messadi L

更新日期：2019-11-01 00:00:00