Effect of CD40 ligand and other immunomodulators on Pneumocystis carinii infection in rat model.

Abstract:

:The corticosteroid-treated animal is well established as an experimental model for the study of Pneumocystis carinii pneumonitis (PCP). Latent or acquired infection with P. carinii in the murine lung progresses to fatal pneumonitis when the host is profoundly immunocompromized. In this study the effects of five immunomodulators; recombinant CD40 ligand (CD40L), bryostatin 1, recombinant FLT3 ligand (FLT3L), recombinant granulocyte colony-stimulating factor (G-CSF) and recombinant interleukin-15 (IL-15) were investigated against PCP in a dexamethasone immunosuppressed Sprague-Dawley rat model. The majority of rats (70%) treated with CD40L at the onset of dexamethasone immunosuppression were protected against PCP. When CD40L was given after 10 days of immunosuppression, only 40% of the rats resolved the infection. However, 95% of the control animals developed PCP. Immunosuppressed rats treated with bryostatin 1, an immune activator had a partial (50%) protection against P. carinii infection. In contrast, daily administration of FLT3L, IL-15 or G-CSF provided no protection against P. carinii infection.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Oz HS,Hughes WT,Rehg JE,Thomas EK

doi

10.1006/mpat.2000.0374

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

187-90

issue

3

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(00)90374-7

journal_volume

29

pub_type

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