当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > The major circulating immunosuppressive activity in American visceral leishmaniasis patients is associated with a high-molecular weight fraction and is not mediated by IgG, IgG immune complexes or lipoproteins.

The major circulating immunosuppressive activity in American visceral leishmaniasis patients is associated with a high-molecular weight fraction and is not mediated by IgG, IgG immune complexes or lipoproteins.

Abstract：

:Opportunistic infections, due to disease-related immunosuppression, constitute the major cause of death in American visceral leishmaniasis (AVL). Sera from these patients (AVL sera) non-specifically inhibit the in vitro proliferative response of normal human lymphocytes to lectins or antigens. In the present work, the mediation of this inhibition by IgG, immune complexes and low- or very low-density lipoproteins was studied. AVL serum fractions containing proteins with the molecular weight of IgG, and IgG, purified from AVL sera by anion exchange chromatography, did not suppress the lymphoproliferation. Most of the suppressive activity of AVL sera was associated with a fraction containing molecules with molecular weights above 430 kDa. This would be compatible with it being due to immune complexes and/or lipoproteins, and not to soluble IL-2 receptors as reported previously. However, neither of the two possibilities seem to be the case, as (1) depletion of immune complexes by protein-A followed by protein-G chromatographies did not affect the serum suppressive activity, (2) no correlation between immune complex contents and suppressive activities in individual sera was observed, and (3) plasma lipoproteins (VLDL and LDL), purified from AVL patients and from healthy individuals, had the same degree of immunosuppressive activity.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Soares NM,Ferraz TP,Nascimento EG,Carvalho EM,Pontes-de-Carvalho L

doi

10.1016/j.micpath.2006.02.005

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

254-60

issue

6

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(06)00031-3

journal_volume

40

pub_type

杂志文章

相关文献

MICROBIAL PATHOGENESIS文献大全
  • Adhesion, invasion and intracellular replication of Salmonella typhimurium in a murine hepatocyte cell line. Effect of cytokines and LPS on antibacterial activity of hepatocytes.

    abstract：:Elimination of pathogenic microorganisms in the liver may be an important effector mechanism in host defenses. In this paper we describe the adhesion, invasion and multiplication of Salmonella typhimurium in a murine embryonic hepatocyte cell line (ATCC TIB-73). Monolayers of hepatocytes treated with recombinant IFN g...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1996.0065

    authors： Lajarin F,Rubio G,Galvez J,Garcia-Peñarrubia P

    更新日期：1996-11-01 00:00:00

  • The 95ΔG mutation in the 5'untranslated region of the norA gene increases efflux activity in Staphylococcus epidermidis isolates.

    abstract：:In the Staphylococcus aureus ATCC25923 strain, the flqB mutation in the 5'untranslated region (5'UTR) of the norA gene causes increased norA mRNA expression and high efflux activity (HEA). The involvement of the norA gene 5'UTR in HEA has not been explored in S. epidermidis; therefore, we examined the function of this...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.12.021

    authors： García-Gómez E,Jaso-Vera ME,Juárez-Verdayes MA,Alcántar-Curiel MD,Zenteno JC,Betanzos-Cabrera G,Peralta H,Rodríguez-Martínez S,Cancino-Díaz ME,Jan-Roblero J,Cancino-Diaz JC

    更新日期：2017-02-01 00:00:00

  • Comparative analysis of Bacterial Vaginosis microbiota among pregnant and non-pregnant females and isolation of phages against Enterococcus faecalis, Enterococcus faecium, and Shigella flexneri strains.

    abstract：BACKGROUND AND OBJECTIVES:Bacterial vaginosis (BV) is the most common vaginal infection in women of reproductive age. It shifts the paradigms of the vagina from healthy, beneficial microbiota to facultative and strict anaerobes. BV remains one of the most arduous and controversial challenges in modern-day clinical micr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104588

    authors： Javed A,Manzoor S

    更新日期：2020-12-01 00:00:00

  • Acyl homoserine lactone changes the abundance of proteins and the levels of organic acids associated with stationary phase in Salmonella Enteritidis.

    abstract：:Quorum sensing (QS) is cell-cell communication mechanism mediated by signaling molecules known as autoinducers (AIs) that lead to differential gene expression. Salmonella is unable to synthesize the AI-1 acyl homoserine lactone (AHL), but is able to recognize AHLs produced by other microorganisms through SdiA protein....

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.11.027

    authors： de Almeida FA,Pimentel-Filho NJ,Carrijo LC,Bento CBP,Baracat-Pereira MC,Pinto UM,de Oliveira LL,Vanetti MCD

    更新日期：2017-01-01 00:00:00

  • Expression of the low calcium response in Yersinia pestis.

    abstract：:Pathogenic yersiniae undergo an established low calcium response (LCR) at 37 degrees C in Ca2+-deficient media characterized by restricted growth with synthesis of Lcr plasmid-encoded virulence functions. The latter include outer membrane peptides (Yops) known to undergo Pst plasmid-mediated post-translational degrada...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(89)90070-3

    authors： Mehigh RJ,Sample AK,Brubaker RR

    更新日期：1989-03-01 00:00:00

  • Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection.

    abstract：:The involvement of nitric oxide (NO) in host defense and cytoprotective functions in murine salmonellosis has been reported. Salmonella mutants with the altered sigma factor RpoS (sigmaS) are less virulent and are susceptible to various stresses. This study investigated the role of the rpoS gene of Salmonella enterica...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2005.11.007

    authors： Alam MS,Zaki MH,Yoshitake J,Akuta T,Ezaki T,Akaike T

    更新日期：2006-03-01 00:00:00

  • Transcriptional analysis reveals the relativity of acid tolerance and antimicrobial peptide resistance of Salmonella.

    abstract：:The objective of this study was to comprehensively identify the target genes induced by acid stimulation in Salmonella, and to clarify the relativity of acid tolerance and antimicrobial peptide resistance. A clinical S. Typhimurium strain, S6, was selected and performed a transcriptome analysis under the acid toleranc...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103701

    authors： Cao L,Wang J,Sun L,Kong Z,Wu Q,Wang Z

    更新日期：2019-11-01 00:00:00

  • Hepatitis E virus seroprevalence rate among Eastern Mediterranean and middle eastern countries; A systematic review and pooled analysis.

    abstract：CONTEXT:Hepatitis E virus (HEV) as a hepatotropic virus is one of the major global health concerns. Autochthonous HEV transmitted by oral fecal-route in poor sanitation conditions as well as vertical and rarely blood transfusion. HEV occurrence is more common in developing countries and recently increased in developed ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2017.06.045

    authors： Karbalaie Niya MH,Rezaee-Zavareh MS,Ranaei A,Alavian SM

    更新日期：2017-09-01 00:00:00

  • In vivo bactericidal effect of Melaleuca alternifolia essential oil against Aeromonas hydrophila: Silver catfish (Rhamdia quelen) as an experimental model.

    abstract：:Aeromonas hydrophila is one of the main causative agent of high mortality and significative economic losses in aquaculture and has become increasingly resistant to conventional antibiotics. One feasible alternative to control and treat it is the use of essential oils. This study aimed to evaluate A. hydrophila suscept...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.07.002

    authors： F Souza C,Baldissera MD,A Vaucher R,Lopes LQ,Vizzotto BS,Raffin RP,Santos RC,L da Veiga M,U M da Rocha MI,Stefani LM,Baldisserotto B

    更新日期：2016-09-01 00:00:00

  • AdeB efflux pump gene knockdown by mRNA mediated peptide nucleic acid in multidrug resistance Acinetobacter baumannii.

    abstract：:Multidrug-resistant Acinetobacter baumannii isolates cause critical problems in health-care environments. AdeABC is a resistance-nodulation-cell division (RND)-type multidrug efflux pump conferring resistance to clinically essential antibiotics in A. baumannii, such as ciprofloxacin. This study aimed to target adeB ge...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103825

    authors： Abdi SN,Ghotaslou R,Asgharzadeh M,Mehramouz B,Hasani A,Baghi HB,Tanomand A,Narenji H,Yousefi B,Gholizadeh P,Yousefi M,Bastami M,Ganbarov K,Samadi Kafil H

    更新日期：2020-02-01 00:00:00

  • Interest of bacterial pangenome analyses in clinical microbiology.

    abstract：:Thanks to the progress and decreasing costs in genome sequencing technologies, more than 250,000 bacterial genomes are currently available in public databases, covering most, if not all, of the major human-associated phylogenetic groups of these microorganisms, pathogenic or not. In addition, for many of them, sequenc...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104275

    authors： Anani H,Zgheib R,Hasni I,Raoult D,Fournier PE

    更新日期：2020-12-01 00:00:00

  • Identification of a maltose-inducible major outer membrane protein in Actinobacillus (Haemophilus) pleuropneumoniae.

    abstract：:The addition of maltose to the growth media of Actinobacillus pleuropneumonia (serotype 1) resulted in the induction of an outer membrane protein (OMP) with a molecular mass of 42 kDa. This protein had porin-like properties in that it was peptidoglycan-associated and was resistant to proteolysis by trypsin. A pleuropn...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(89)90084-3

    authors： Deneer HG,Potter AA

    更新日期：1989-06-01 00:00:00

  • Modulation of the antibiotic activity against multidrug resistant strains of coumarins isolated from Rutaceae species.

    abstract：:The first occurrences and dissemination of resistant microorganisms led to the inefficacy of many antibiotics, available in the market nowadays, therefore, the search for new substances with antimicrobial activity from natural sources has gained a great importance. The purpose of this work is to evaluate the antibacte...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.01.028

    authors： Madeiro SA,Borges NH,Souto AL,de Figueiredo PT,Siqueira-Junior JP,Tavares JF

    更新日期：2017-03-01 00:00:00

  • Species-specific B-cell epitope on the C-terminal region of the alpha antigen from Mycobacterium scrofulaceum.

    abstract：:In the amino acid (AA) sequences of alpha antigen from mycobacteria, C-terminal regions were variable among a variety of mycobacterial species though the N-terminal regions were relatively conserved. These regions may possess some species-specific antigenic determinants of the alpha antigen from Mycobacterium scrofula...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1997.0147

    authors： Takano M,Ohara N,Naito M,Matsumoto S,Matsuo T,Shirai R,Mizuno A,Yamada T

    更新日期：1997-08-01 00:00:00

  • Clinico-hematological and oxidative stress status in Nili Ravi buffaloes infected with Trypanosoma evansi.

    abstract：:Hemoparasitic diseases like trypanosomiasis have an adverse influence on the health and working capability of infected animals. Monitoring and identification of blood born parasitic infections in dairy animals are of vital importance to get the optimum production. In this study blood samples were collected from Nili R...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.07.001

    authors： Hussain R,Khan A,Jahanzaib,Qayyum A,Abbas T,Ahmad M,Mohiuddin M,Mehmood K

    更新日期：2018-10-01 00:00:00

  • Complete genome sequence of Janthinobacterium sp. B9-8, a violacein-producing bacterium isolated from low-temperature sewage.

    abstract：:Janthinobacterium sp. B9-8, isolated from low temperature-sewage in Xinjiang, China, is capable of producing violacein, a promising antibiotic. Here we report the genome sequence of B9-8, which consist of 4,726,850 bp with a G + C content of 48.72%. The violacein biosynthesis gene cluster vioABCDE was identified and a...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.01.003

    authors： Xu X,Tian L,Zhang S,Jiang L,Zhang Z,Huang H

    更新日期：2019-03-01 00:00:00

  • Fis is required for proper regulation of ssaG expression in Salmonella enterica serovar Typhimurium.

    abstract：:Salmonella pathogenicity island 2 (SPI2) encodes a type III secretion system (TTSS) necessary for bacterial survival and replication in intracellular environment of host cells. SPI2 genes are transcribed preferentially after Salmonella enters the host cells. Transcriptional regulation of ssaG encoding the component of...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2006.03.005

    authors： Lim S,Kim B,Choi HS,Lee Y,Ryu S

    更新日期：2006-07-01 00:00:00

  • Differences in biofilm formation and virulence factors between clinical and fecal enterococcal isolates of human and animal origin.

    abstract：:The present study investigated the possible correlation between carriage of the virulence genes esp and fsrb, production of hemolysin and gelatinase and biofilm formation in human vs. animal enterococcal isolates. A collection of 219 enterococcal isolates recovered from clinical and fecal surveillance samples of hospi...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2012.03.003

    authors： Tsikrikonis G,Maniatis AN,Labrou M,Ntokou E,Michail G,Daponte A,Stathopoulos C,Tsakris A,Pournaras S

    更新日期：2012-06-01 00:00:00

  • Bioavailability-enhanced Resveramax™ modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1.

    abstract：:Quorum sensing (QS), a cell-to-cell communication mechanism present in many bacterial species plays a key role in regulating the virulence factor and biofilm formation in many pathogens, which causes severe public health risk. Therefore, interfering with QS mechanism offers an attractive strategy to combat bacterial i...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.01.015

    authors： Vasavi HS,Sudeep HV,Lingaraju HB,Shyam Prasad K

    更新日期：2017-03-01 00:00:00

  • Identification of proteins involved in the adhesionof Candida species to different medical devices.

    abstract：:Adhesion is the first step for Candida species to form biofilms on medical devices implanted in the human host. Both the physicochemical nature of the biomaterial and cell wall proteins (CWP) of the pathogen play a determinant role in the process. While it is true that some CWP have been identified in vitro, little is...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.04.009

    authors： Núñez-Beltrán A,López-Romero E,Cuéllar-Cruz M

    更新日期：2017-06-01 00:00:00

  • Mutation of purD and purF genes further attenuates Brucella abortus strain RB51.

    abstract：:In the present study, transposon mutagenesis was used to further attenuate Brucella abortus RB51 vaccine strain. Two purD and purF mutants were constructed, characterized and evaluated for attenuation via intracellular survival in murine macrophage-like RAW264.7 and HeLa cells, and by clearance in BALB/c mice. The pur...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2014.12.003

    authors： Truong QL,Cho Y,Barate AK,Kim S,Watarai M,Hahn TW

    更新日期：2015-02-01 00:00:00

  • Detection of genetic diversity in linear plasmids 28-3 and 36 in Borrelia burgdorferi sensu stricto isolates by subtractive hybridization.

    abstract：:Recent studies based on sequence divergence in the ospC gene have identified limited subpopulations of B. burgdorferi associated with invasive human disease. Spirochetes with certain OspC types never cause human disease, while some others cause local infection at the primary skin site but do not hematogenously dissemi...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/s0882-4010(03)00152-9

    authors： Xu Y,Bruno JF,Luft BJ

    更新日期：2003-12-01 00:00:00

  • Structural basis for isoniazid resistance in KatG double mutants of Mycobacterium tuberculosis.

    abstract：:The failure of drugs for effective treatment against infectious diseases can be attributed to resistant forms of causative agents. The evasive nature of Mycobacterium tuberculosis is partly associated to its physical features, such as having a thick cell wall and incorporation of beneficial mutations leading to drug r...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.02.003

    authors： Rabha A,Singh A,Grover S,Kumari A,Pandey B,Grover A

    更新日期：2019-04-01 00:00:00

  • Recombinant C-terminal 311 amino acids of HapS adhesin as a vaccine candidate for nontypeable Haemophilus influenzae: A study on immunoreactivity in Balb/C mouse.

    abstract：:Hap, an auto-transporter protein, is an antigenically conserved adhesion protein which is present on both typeable and nontypeable Haemophilus influenzae. This protein has central role in bacterial attachment to respiratory tract epithelial cells. A 1000bp C-terminal fragment of Hap passenger domain (HapS) from nontyp...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.06.033

    authors： Tabatabaee Bafroee AS,Siadat SD,Mousavi SF,Aghasadeghi MR,Khorsand H,Nejati M,Sadat SM,Mahdavi M

    更新日期：2016-09-01 00:00:00

  • Detection of feline haemoplasma species in experimental infections by in-situ hybridisation.

    abstract：:The aim of this study was to use fluorescence in-situ hybridisation (FISH) to search for the tissues and cell types important in survival and persistence of Mycoplasma haemofelis, "Candidatus Mycoplasma haemominutum" or "Candidatus Mycoplasma turicensis" in infected cats. A 16S rDNA probe for each species was applied ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2010.09.003

    authors： Peters IR,Helps CR,Willi B,Hofmann-Lehmann R,Gruffydd-Jones TJ,Day MJ,Tasker S

    更新日期：2011-02-01 00:00:00

  • Genetic organization of the she pathogenicity island in Shigella flexneri 2a.

    abstract：:In this study we report the complete nucleotide sequence and genetic organization of the she pathogenicity island (PAI) of Shigella flexneri 2a strain YSH6000T. The 46 603 bp she PAI is situated adjacent to the 3' terminus of the pheV tRNA gene and includes an imperfect direct repeat of the 3'-terminal 22 bp of the ph...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0404

    authors： Al-Hasani K,Rajakumar K,Bulach D,Robins-Browne R,Adler B,Sakellaris H

    更新日期：2001-01-01 00:00:00

  • Establishment of a cell line from egg of rare minnow Gobiocypris rarus for propagation of grass carp reovirus genotype II.

    abstract：:The rare minnow, Gobiocypris rarus, is small experimental fish proven to be sensitive to Grass Carp Reovirus (GCRV) infection. In present study we established a new cell (GrE) from eggs of G. rarus. GrE cells grew well at 28 °C in M199 medium containing 10% fetal bovine serum, and has been subcultured for over 70 pass...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103715

    authors： Liu S,Wang Y,Chen J,Wang Q,Chang O,Zeng W,Bergmann SM,Li Y,Yin J,Wen H

    更新日期：2019-11-01 00:00:00

  • The luxS gene functions in the pathogenesis of avian pathogenic Escherichia coli.

    abstract：:Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, the most significant infectious bacterial disease of poultry worldwide. LuxS, the product of the luxS gene, mediates the quorum sensing (QS) mechanism. This involves the production of autoinducer-2 (AI-2), which regulates important physiological tra...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2012.09.008

    authors： Han X,Bai H,Liu L,Dong H,Liu R,Song J,Ding C,Qi K,Liu H,Yu S

    更新日期：2013-02-01 00:00:00

  • Saccharomyces cerevisiae from Brazilian kefir-fermented milk: An in vitro evaluation of probiotic properties.

    abstract：:The therapeutic use of probiotics for supporting the antibiotic action against gastrointestinal disorders is a current trend and emerging applications have gained popularity because of their support for various microbiological activities in digestive processes. Microorganisms isolated from kefir with great probiotic p...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.05.010

    authors： Lima MDSF,Souza KMS,Albuquerque WWC,Teixeira JAC,Cavalcanti MTH,Porto ALF

    更新日期：2017-09-01 00:00:00

  • Microbial radiosensitization using combined treatments of essential oils and irradiation- part B: Comparison between gamma-ray and X-ray at different dose rates.

    abstract：:Stored rice and rice products are prone to contamination by pathogenic fungi and bacteria such as Aspergillus niger, Bacillus cereus, and Paenibacillus amylolyticus. Treatment with antimicrobial essential oils (EOs) and irradiation are options to control spoilage organisms. Microbial samples with or without fumigation...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104118

    authors： Shankar S,Follett P,Ayari S,Hossain F,Salmieri S,Lacroix M

    更新日期：2020-06-01 00:00:00