当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > Bioavailability-enhanced Resveramax™ modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1.

Bioavailability-enhanced Resveramax™ modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1.

Abstract：

:Quorum sensing (QS), a cell-to-cell communication mechanism present in many bacterial species plays a key role in regulating the virulence factor and biofilm formation in many pathogens, which causes severe public health risk. Therefore, interfering with QS mechanism offers an attractive strategy to combat bacterial infections. In the present study, anti-QS activity of a novel resveratrol formulation, Resveramax™, was detected using Chromobacterium violaceum biosensor bioassay and the effect of Resveramax on QS-regulated phenotypes in Pseudomonas aeruginosa PAO1 was assessed by standard protocols. Molecular docking analysis of resveratrol, the major active constituent of Resveramax, with LasR receptor protein was performed to evidence the QS-inhibitory potential of Resveramax. Results showed that Resveramax specifically inhibited the QS-mediated violacein pigment production in C. violaceum; pyocyanin production, proteolytic activity, swarming motility and biofilm formation in P. aeruginosa PAO1 in a concentration-dependent manner. Biofilms treated with Resveramax showed increased susceptibility to antibiotics when compared with the antibiotic treatment alone. Molecular docking analysis proved that resveratrol binds more rigidly with LasR receptor protein with docking score of -8.55 kJ/mol. These findings suggest that Resveramax could be used as novel QS-based antibacterial/anti-biofilm agent for the management of bacterial infections.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Vasavi HS,Sudeep HV,Lingaraju HB,Shyam Prasad K

doi

10.1016/j.micpath.2017.01.015

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

64-71

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(16)30056-0

journal_volume

104

pub_type

杂志文章

相关文献

MICROBIAL PATHOGENESIS文献大全
  • Opportunistic fungi in lake water and fungal infections in associated human population in Dal Lake, Kashmir.

    abstract：:Natural habitats of opportunistic fungal pathogens are outside of the host; therefore, it is critically important to understand their ecology and routes of transmission. In this study, we investigated the presence of human pathogenic opportunistic fungi in lake water and incidence of fungal infections in associated po...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.01.022

    authors： Bandh SA,Kamili AN,Ganai BA,Lone BA

    更新日期：2016-04-01 00:00:00

  • Changes in ovine erythrocyte morphology due to sphingomyelin degradation by Corynebacterium pseudotuberculosis phospholipase D.

    abstract：:Corynebacterium pseudotuberculosis produces a sphingomyelin-specific phospholipase D exotoxin that is a major determinant in the pathogenesis of caseous lymphadenitis. We assessed the changes induced in the morphology and sphingomyelin concentration of ovine erythrocytes after incubation with broth culture filtrates o...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(90)90080-a

    authors： Brogden KA,Engen RL,Songer JG,Gallagher J

    更新日期：1990-02-01 00:00:00

  • The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus.

    abstract：:An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by insertional mutagenesis, and the MdaB protein was purified and compared to the Helicobacter pylori enzyme. While wild type H. hepaticus cells could tolerate 6% O(2) for growth, the mdaB strain was cle...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2006.08.005

    authors： Hong Y,Wang G,Maier RJ

    更新日期：2008-02-01 00:00:00

  • Velogenic newcastle disease virus tissue tropism and pathogenesis of infection in chickens by application of in situ PCR, immunoperoxase staining and HE staining.

    abstract：:Limited deep studies are available in the field of early stages of pathogenesis of Newcastle disease virus (NDV) infection and tissue tropism of NDV. In this study, 24 specific pathogen free (SPF) chickens of white leghorn breed were infected with Newcastle disease (ND) by intranasal administration of 10⁵ 50% EID50/0....

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.02.017

    authors： Hussein EA,Hair-Bejo M,Omar AR,Arshad SS,Hani H,Balakrishnan KN,Yakubu Y,Saeed MI,Aini I

    更新日期：2019-04-01 00:00:00

  • First whole genome sequencing of Russian isolate of Capnocytophaga canimorsus, opportunistic pathogen causing lethal sepsis.

    abstract：:Capnocytophaga canimorsus is a part of healthy oral flora of dogs and cats. However, when it is transmitted to human subjects via animal bites or scratches, it can cause severe complications like endocarditis or even lethal septic shock, especially in immunocompromised persons. In this study, we performed the first wh...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.10.020

    authors： Shelenkov AA,Karan LS,Mihaylova YV,Yanushevich YG,Shipulin GA,Shagin DA

    更新日期：2018-12-01 00:00:00

  • Comparison of the RE-529 sequence and B1 gene for Toxoplasma gondii detection in blood samples of the at-risk seropositive cases using uracil DNA glycosylase supplemented loop-mediated isothermal amplification (UDG-LAMP) assay.

    abstract：:Diagnosis of toxoplasmosis is an important issue, especially in at-risk patients. The molecular methods showed a promising future for such diagnosis; however, the method itself and the target sequence to be detected is an important part of accurate detection of the infection. The aim of the present study was to evalua...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103938

    authors： Valian HK,Mirhendi H,Mohebali M,Shojaee S,Fallahi S,Jafari R,Kheirandish F,Mousavi P

    更新日期：2020-03-01 00:00:00

  • Indole reduces the expression of virulence related genes in Vibrio splendidus pathogenic to sea cucumber Apostichopus japonicus.

    abstract：:Indole is a metabolite of tryptophan that can be synthesized by various bacteria. In the present study, production of indole by Vibrio splendidus Vs was determined using Kovac's reagent, and m/z was further determined by HPLC-MS. Extracellular indole reached a maximum concentration of 160 μM, when OD600 of V. splendid...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.08.032

    authors： Zhang S,Zhang W,Liu N,Song T,Liu H,Zhao X,Xu W,Li C

    更新日期：2017-10-01 00:00:00

  • Application of artificial neural networks to describe the combined effect of pH, time, NaCl and ethanol concentrations on the biofilm formation of Staphylococcus aureus.

    abstract：:Biofilms are organized communities, adherent to the surface and resistant to adverse environmental and antimicrobial agents. So, its control is very important. Staphylococcus aureus is an opportunistic pathogen with the biofilm-forming ability that causes numerous problems in the medicine and food industry. Therefore,...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.103986

    authors： Vaezi SS,Poorazizi E,Tahmourespour A,Aminsharei F

    更新日期：2020-04-01 00:00:00

  • Comparative genomic analyses of two novel qnrVC6 carrying multidrug-resistant Pseudomonas. spp strains.

    abstract：OBJECTIVES:This study focused on the comparative genomic analyses of two qnrVC6 carrying Pseudomonas spp. strains which might give us insights on the similarity and difference in the genomic contexts of qnrVC6 gene. METHODS:Comparative genomic analyses of the novel qnrVC6 carrying Pseudomonas spp. genomes with emphasi...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.07.026

    authors： Liu J,Yang L,Li L,Li B,Chen D,Xu Z

    更新日期：2018-10-01 00:00:00

  • Alveolar microbiota profile in patients with human pulmonary tuberculosis and interstitial pneumonia.

    abstract：BACKGROUND:The presence of the human lung microbiota has been demonstrated in patients with different lung diseases, mainly in sputum samples. However, for study of the alveolar microbiota, a bronchoalveolar lavage (BAL) sample represents the lower respiratory tract (LRT) environment. It is currently unknown whether th...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103851

    authors： Vázquez-Pérez JA,Carrillo CO,Iñiguez-García MA,Romero-Espinoza I,Márquez-García JE,Falcón LI,Torres M,Herrera MT

    更新日期：2020-02-01 00:00:00

  • Need for TolC, an Escherichia coli outer membrane protein, in the secretion of heat-stable enterotoxin I across the outer membrane.

    abstract：:Escherichia coli heat-stable enterotoxin Ip (STIp) is a typical extracellular toxin consisting of 18 amino acid residues synthesized as a precursor of pre (amino acid residues 1 to 19), pro (amino acid residues 20 to 54), and mature (amino acid residues 55 to 72) regions. STIp synthesized in the cytoplasm must cross t...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1998.0211

    authors： Yamanaka H,Nomura T,Fujii Y,Okamoto K

    更新日期：1998-09-01 00:00:00

  • Alteration of gene expression in human middle ear epithelial cells induced by influenza A virus and its implication for the pathogenesis of otitis media.

    abstract：:Influenza A virus infection plays a significant role in the pathogenesis of Streptococcus pneumoniae-induced acute otitis media in children. An understanding of how influenza A virus modulates host cellular responses is critically important in efforts to explore the molecular mechanisms of this synergism. We used micr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2004.06.012

    authors： Tong HH,Long JP,Li D,DeMaria TF

    更新日期：2004-10-01 00:00:00

  • Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora.

    abstract：:Escherichia coli O157:H7 is a food-borne pathogen that can cause hemorrhagic colitis and, occasionally, hemolytic uremic syndrome, a sequela of infection that can result in renal failure and death. Here we sought to model the pathogenesis of orally-administered E. coli O157:H7 in BALB/c mice with an intact intestinal ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2010.01.003

    authors： Mohawk KL,Melton-Celsa AR,Zangari T,Carroll EE,O'Brien AD

    更新日期：2010-03-01 00:00:00

  • Determination of immunodominant scaffolds of Com1 and OmpH antigens of Coxiella burnetii.

    abstract：:Today, there is an increasing emphasis on recombinant vaccines to eliminate the side effects of conventional vaccines such as whole-cell bacteria. Query fever is an emerging disease that causes irreparable complications for both humans and domestic animals. The cause of this disease is Coxiella burnetii, a gram-negati...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.11.012

    authors： Jaydari A,Forouharmehr A,Nazifi N

    更新日期：2019-01-01 00:00:00

  • A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes.

    abstract：:Attenuated recombinant Listeria monocytogenes (Lm) strains are a promising class of vaccine vectors that trigger protective antigen-specific CD8 T cells. Listeriolysin O (LLO) is an important Lm virulence determinant allowing the bacterium to escape from the endocytic vacuole into the cell cytoplasm in phagocytic cell...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2007.08.002

    authors： Orgun NN,Way SS

    更新日期：2008-02-01 00:00:00

  • Nanoparticles and their antimicrobial properties against pathogens including bacteria, fungi, parasites and viruses.

    abstract：:In recent year, propagation and resistance of pathogenic microorganisms (bacteria, fungi and virals) to common antimicrobial agents has led to serious health and food problems. Today, nanotechnology science and nanoparticles (NPs) have been identified as a new approach to deal with this problem because of their inhere...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2018.08.008

    authors： Khezerlou A,Alizadeh-Sani M,Azizi-Lalabadi M,Ehsani A

    更新日期：2018-10-01 00:00:00

  • Identification of viable and non-viable Mycobacterium tuberculosis in mouse organs by directed RT-PCR for antigen 85B mRNA.

    abstract：:Mycobacterium tuberculosis (MTB) the causative organism of tuberculosis can remain dormant as a non-culturable organism, reactivate and cause disease in man and animals. There is a need for proof of viability of such organisms in order to understand the process of reactivation. PCR for bacterial DNA cannot distinguish...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0353

    authors： Pai SR,Actor JK,Sepulveda E,Hunter RL Jr,Jagannath C

    更新日期：2000-06-01 00:00:00

  • In silico analysis of four structural proteins of aphthovirus serotypes revealed significant B and T cell epitopes.

    abstract：:Foot and Mouth disease (FMD) is economically devastating, highly contagious transboundry viral disease of livestock with 100% morbidity, rapid spread and severe production losses in animals. The FMDV has seven different serotypes. There is no vaccine that can protect animals from all serotypes. Hence, it is need of th...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.01.007

    authors： Raza S,Siddique K,Rabbani M,Yaqub T,Anjum AA,Ibrahim M,Azhar M,Jamil F,Rasheed MA

    更新日期：2019-03-01 00:00:00

  • Inhibition of TLR8 mediated signaling promotes BCG induced apoptosis in THP-1 cells.

    abstract：:Apoptosis was considered as one of the important host defense mechanisms against mycobacteria infection. In macrophage, the main target cell of Mycobacterium tuberculosis, apoptosis after infection could help kill the bacillus inside and process the antigens for further presentation and proper immune response. Here, w...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2015.11.028

    authors： Tang J,Zhan L,Qin C

    更新日期：2016-04-01 00:00:00

  • Molecular surveillance of candidemia due to Candida albicans among cancer patients during 2009 to 2013 by microsatellite typing.

    abstract：BACKGROUND:Since the high morbidity and mortality of candidemia among cancer patients, the epidemiology has been underlined. In recent years, Candida species genotyping has been established, which could provide detail characteristics of epidemiology and has been underscored for candidemia preventing strategies. METHOD...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2015.03.005

    authors： Li D,Li X,Xia R,Zhang W,Zheng S,Zhang Q,Bai C,Zhang P

    更新日期：2015-04-01 00:00:00

  • Epigallocatechin gallate can attenuate human alveolar epithelial cell injury induced by alpha-haemolysin.

    abstract：:Staphylococcus aureus (S. aureus) is a common cause of hospital-acquired infection and has become an epidemic globally. Alpha-haemolysin (α-haemolysin), a pore-forming toxin, is one of the most important virulence factors secreted by most S. aureus strains. α-haemolysin monomers form a 232.4-kDa membrane-inserted hept...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.12.054

    authors： Zhou Y,Chen C,Pan J,Deng X,Wang J

    更新日期：2018-02-01 00:00:00

  • Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection.

    abstract：:The involvement of nitric oxide (NO) in host defense and cytoprotective functions in murine salmonellosis has been reported. Salmonella mutants with the altered sigma factor RpoS (sigmaS) are less virulent and are susceptible to various stresses. This study investigated the role of the rpoS gene of Salmonella enterica...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2005.11.007

    authors： Alam MS,Zaki MH,Yoshitake J,Akuta T,Ezaki T,Akaike T

    更新日期：2006-03-01 00:00:00

  • Nutritional interference for phenotypic biofilm quantification in Aeromonas spp. isolates containing the fla gene.

    abstract：:The Aeromonas genus has several virulence factors associated with the development of diseases in aquatic organisms, leading to losses in aquaculture. One of these factors is the flagella's formation which allows the biofilm's formation that provides the microorganisms a greater pathogenicity, greater protection to cer...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.11.044

    authors： Freire NB,Magalhães TC,Nunes Soares RA,da Costa MM,Gouveia GV

    更新日期：2019-02-01 00:00:00

  • Expression and sequence diversity of the complement regulating outer surface protein E in Borrelia afzelii vs. Borrelia garinii in patients with erythema migrans or neuroborreliosis.

    abstract：:Outer surface protein E (OspE) is a complement factor H-binding virulence factor of borrelial subspecies. It is usually absent from in vitro grown Borrelia garinii, although in vivo B. garinii causes neuroborreliosis (NB). We analyzed the presence and sequence spectrum of the ospE genes in vivo in Borrelia spirochetes...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2010.06.006

    authors： Panelius J,Ranki A,Meri T,Seppälä I,Meri S

    更新日期：2010-12-01 00:00:00

  • Occurrence of Mycoplasma genitalium in the peritoneal fluid of fertile and infertile women with detailed analysis among infertile women.

    abstract：OBJECTIVE:To determine the frequency of occurrence of Mycoplasma genitalium infection in the peritoneal fluid of infertile women as compared to fertile women. MATERIALS AND METHODS:We have selected 162 infertile women aged 22-40 years as study subject and 162 women posted for elective caesarean section, were taken as ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.02.006

    authors： Rekha S,Nooren M,Kalyan S,Mohan M,Bharti M,Monika R,Anita S,Kiran M,Vandana N

    更新日期：2019-04-01 00:00:00

  • Evaluation of the antioxidant properties of carexanes in AGS cells transfected with the Helicobacter pylori's protein HspB.

    abstract：:Naturally derived compounds represent a potential source of pharmacologically active drugs able to contrast different diseases, including gastric cancer, a multifactorial disease, in which the important role played by H. pylori infection has been demonstrated. Carexanes, stilbene derivatives, isolated from plants of t...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.05.007

    authors： Buommino E,D'Abrosca B,Donnarumma G,Parisi A,Scognamiglio M,Fiorentino A,De Luca A

    更新日期：2017-07-01 00:00:00

  • NOD1/NF-κB signaling pathway inhibited by sodium butyrate in the mammary gland of lactating goats during sub-acute ruminal acidosis.

    abstract：:Animals nurtured with a high-concentrate diet for a more extended period can cause subacute ruminal acidosis (SARA). In this study, twelve mid-lactating goats were separated into two groups (n = 6): a high concentrate diet (HC) control and a high concentrate with buffer (HCB) treatment group. Rumen fistula was install...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.05.045

    authors： Aabdin ZU,Bilal MS,Dai H,Abaker JA,Liu X,Benazir S,Yan J,Shen X

    更新日期：2018-09-01 00:00:00

  • Amphotericin B-conjugated biogenic silver nanoparticles as an innovative strategy for fungal infections.

    abstract：:New strategies are required to improve the efficacy of drugs and to treat the emerging microbial resistance. An effective strategy is to combine drugs with metal nanoparticles for the control of microbial infections and resistance. Keeping in view this fact, we developed a facile and eco-friendly protocol for the synt...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.08.031

    authors： Ahmad A,Wei Y,Syed F,Tahir K,Taj R,Khan AU,Hameed MU,Yuan Q

    更新日期：2016-10-01 00:00:00

  • Protective immunity induced by a DNA vaccine cocktail expressing TgSAG1, TgROP2, and the genetic adjuvant HBsAg against Toxoplasma gondii infection.

    abstract：:Toxoplasma gondii is an intracellular obligate parasitic protozoon that can infect all warm-blooded animals, causing zoonotic toxoplasmosis. So far, there is no commercial toxoplasmosis vaccine for human use. In the present study, we constructed a DNA vaccine cocktail which includes the surface protein (SAG1) and the ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104441

    authors： Sun H,Li J,Xiao T,Huang XD,Wang LJ,Huang BC,Yin K,Liu GZ,Xu C,Wei QK

    更新日期：2020-10-01 00:00:00

  • Deletions of chromosomal regions coding for fimbriae and hemolysins occur in vitro and in vivo in various extraintestinal Escherichia coli isolates.

    abstract：:Fimbrial adhesins and hemolysins contribute to pathogenicity of extraintestinal Escherichia coli isolates causing urinary tract infections (UTI), sepsis and new born meningitis (NBM). Using gene cloning techniques and pulse field electrophoresis in combination with Southern hybridizations it was demonstrated that the ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(90)90048-u

    authors： Hacker J,Bender L,Ott M,Wingender J,Lund B,Marre R,Goebel W

    更新日期：1990-03-01 00:00:00