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Epigallocatechin gallate can attenuate human alveolar epithelial cell injury induced by alpha-haemolysin.

Abstract：

:Staphylococcus aureus (S. aureus) is a common cause of hospital-acquired infection and has become an epidemic globally. Alpha-haemolysin (α-haemolysin), a pore-forming toxin, is one of the most important virulence factors secreted by most S. aureus strains. α-haemolysin monomers form a 232.4-kDa membrane-inserted heptamer by self-assembling to cause host cell lysis and death. Consequently, α-haemolysin plays a significant role in the pathogenesis of S. aureus, and it could be the target for the treatment of staphylococcal infection. In this study, epigallocatechin gallate (EGCg), a natural compound with little anti-S. aureus activity, was shown to reduce the haemolytic activity of α-haemolysin by inhibiting the self-assembly of the heptamer. When EGCg was added into a co-cultured system of human alveolar epithelial (A549) cells and bacterial suspension, α-haemolysin-induced cell injury was significantly attenuated. These results indicate that EGCg could effectively reduce the cytotoxicity of the toxin by interacting with α-haemolysin. This study provides the basis for the development of anti-virulence drugs for the treatment of S. aureus infection.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Zhou Y,Chen C,Pan J,Deng X,Wang J

doi

10.1016/j.micpath.2017.12.054

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

222-226

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(17)31500-0

journal_volume

115

pub_type

杂志文章

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