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Protein D expression promotes the adherence and internalization of non-typeable Haemophilus influenzae into human monocytic cells.

Abstract：

:Protein D, having a glycerol-3-phosphodiester phosphodiesterase activity, is found at the surface of all Haemophilus influenzae strains and is a possible virulence factor. In the present study, the involvement of protein D in the entry of NTHi into human monocytic cells is reported. Primary monocytes and the monocytic cell lines U-937 and THP-1 were infected with NTHi strain 772 and the mutant 772 Delta hpd 1 (lacking the gene for protein D). NTHi 772 adhered to and entered monocytic cells up to four-fold more efficiently compared to 772 Delta hpd 1. When an Escherichia coli transformant expressing protein D was incubated with monocytic cells, the number of intracellular bacteria increased 1.6-fold compared to protein D-deficient controls. Any correlation between internalization and phosphorylcholine expression was not detected. In conclusion, our data suggest that surface-expressed protein D promotes the adherence of NTHi to human monocytes leading to a higher number of internalized bacteria.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Ahrén IL,Janson H,Forsgren A,Riesbeck K

doi

10.1006/mpat.2001.0456

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

151-8

issue

3

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(01)90456-5

journal_volume

31

pub_type

杂志文章

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