当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > Alveolar microbiota profile in patients with human pulmonary tuberculosis and interstitial pneumonia.

Alveolar microbiota profile in patients with human pulmonary tuberculosis and interstitial pneumonia.

Abstract：

BACKGROUND:The presence of the human lung microbiota has been demonstrated in patients with different lung diseases, mainly in sputum samples. However, for study of the alveolar microbiota, a bronchoalveolar lavage (BAL) sample represents the lower respiratory tract (LRT) environment. It is currently unknown whether there is a specific alveolar microbiota profile in human lung diseases, such as pulmonary tuberculosis (TB) and interstitial pneumonia (IP). METHODS:BAL samples from six active TB patients, six IP patients and ten healthy volunteers were used for DNA extraction followed by amplification of the complete bacterial 16S ribosomal RNA gene (16S rDNA). The 16S rDNA was sequenced with a MiSeq Desktop Sequencer, and the data were analysed by QIIME software for taxonomic assignment. RESULTS:The alveolar microbiota in TB and IP patients and healthy volunteers was characterized by six dominant phyla, Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Fusobacteria and Cyanobacteria. A significant reduction in the abundance of Firmicutes was observed in IP patients. In TB and IP patients, the diversity of the alveolar microbiota was diminished, characterized by a significant reduction in the abundance of the Streptococcus genus and associated with increased Mycobacterium abundance in TB patients and diminished Acinetobacter abundance in IP patients with respect to their abundances in healthy volunteers. However, an important difference was observed between TB and IP patients: the Fusobacterium abundance was significantly reduced in TB patients. Exclusive genera that were less abundant in patients than in healthy volunteers were characterized for each study group. CONCLUSIONS:This study shows that the alveolar microbiota profile in BAL samples from TB and IP patients, representing infectious and non-infectious lung diseases, respectively, is characterized by decreased diversity.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Vázquez-Pérez JA,Carrillo CO,Iñiguez-García MA,Romero-Espinoza I,Márquez-García JE,Falcón LI,Torres M,Herrera MT

doi

10.1016/j.micpath.2019.103851

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

103851

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(19)30962-3

journal_volume

139

pub_type

杂志文章

相关文献

MICROBIAL PATHOGENESIS文献大全
  • Nucleotide sequence and expression of an extracellular hemolysin gene of Aeromonas hydrophila.

    abstract：:The extracellular hemolysin (AHH1) gene of Aeromonas hydrophila ATCC7966 was cloned into Charomid9-28 in Escherichia coli DH1, and its complete nucleotide sequence determined. Escherichia coli carrying this gene expressed an extracellular heat-labile hemolysin for rabbit red blood cells. The minimum size of the coding...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(91)90049-g

    authors： Hirono I,Aoki T

    更新日期：1991-09-01 00:00:00

  • Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus).

    abstract：:The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman primates, wild rodents and mosquitoes as well as mice used as sentinels. The virus is able ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103627

    authors： Matos GC,Ferreira MS,Martins Filho AJ,Amador Neto OP,Campos VM,Lima MLG,Rodrigues JCP,Ribeiro ACDS,Freitas MNO,Silva FA,Chiang JO,Casseb LMN,Sousa JR,Quaresma JAS,Martins LC,Vasconcelos PFDC,Carvalho VL

    更新日期：2019-10-01 00:00:00

  • Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant.

    abstract：:Actinobacillus pleuropneumoniae is the pathogen of porcine contagious pleuropneumonia causing great economic losses globally. LuxS is known to be involved in the interspecies quorum sensing by mediating the production of AI-2 signal molecule and play important roles in regulating various behaviors of bacteria. In this...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2008.05.008

    authors： Li L,Zhou R,Li T,Kang M,Wan Y,Xu Z,Chen H

    更新日期：2008-09-01 00:00:00

  • Lack of association between hemolysin production and acute inflammation in human urinary tract infection.

    abstract：:Hemolysins are cytolytic proteins which have been extensively characterized at the molecular level, however, their in vivo functions remain unclear. This study analyzed the association of hemolysin production with the inflammatory response in patients with urinary tract infection (UTI). Infants and children with their...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1993.1045

    authors： Connell H,de Man P,Jodal U,Lincoln K,Svanborg C

    更新日期：1993-06-01 00:00:00

  • Saccharomyces cerevisiae from Brazilian kefir-fermented milk: An in vitro evaluation of probiotic properties.

    abstract：:The therapeutic use of probiotics for supporting the antibiotic action against gastrointestinal disorders is a current trend and emerging applications have gained popularity because of their support for various microbiological activities in digestive processes. Microorganisms isolated from kefir with great probiotic p...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.05.010

    authors： Lima MDSF,Souza KMS,Albuquerque WWC,Teixeira JAC,Cavalcanti MTH,Porto ALF

    更新日期：2017-09-01 00:00:00

  • Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.

    abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) is acknowledged a fulminating infectious pathogen affecting the pig farming industry, and current vaccines and drugs could hardly inhibit this virus. The 2', 5'-oligoadenylate synthetase (OASs) have antiviral activities, but the role(s) played by porcine OAS2...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.08.011

    authors： Zhao M,Wan B,Li H,He J,Chen X,Wang L,Wang Y,Xie S,Qiao S,Zhang G

    更新日期：2017-10-01 00:00:00

  • p38 MAPK signaling pathway activation by phenyl benzoxime in SNU-306 cells causes induction of apoptosis.

    abstract：:The present study was aimed to investigate and understand the mechanism of inhibitory effect of phenyl benzoxime on proliferation of SNU-306 cells. Proliferation of SNU-306 cells transfected with wild-type p53-induced phosphatase 1 (Wip1)-siRNA or treated with phenyl benzoxime was examined by 3-(4,5-dimethythiazol-2-y...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.10.021

    authors： Chen W,Tan Y,Zhang Y

    更新日期：2019-01-01 00:00:00

  • Principle component analysis (PCA) for investigation of relationship between population dynamics of microbial pathogenesis, chemical and sensory characteristics in beef slices containing Tarragon essential oil.

    abstract：:Principle component analysis (PCA) was employed to examine the effect of the exerted treatments on the beef shelf life as well as discovering the correlations between the studied responses. Considering the variability of the dimensions of the responses, correlation coefficients were applied to form the matrix and extr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.02.013

    authors： Alizadeh Behbahani B,Tabatabaei Yazdi F,Shahidi F,Mortazavi SA,Mohebbi M

    更新日期：2017-04-01 00:00:00

  • Potential efficiency of conventional and advanced approaches used to detect Mycobacterium bovis in cattle.

    abstract：:The present study was aimed to assess the prevalence and efficiency of techniques for the diagnosis of bovine tuberculosis (bTB) including enzyme-linked immunosorbent assay (ELISA), Gamma interferon assay (IFN-γ) and polymerase chain reaction (PCR) in comparison to skin tuberculin test and culture technique. A total o...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103574

    authors： Algammal AM,Wahdan A,Elhaig MM

    更新日期：2019-09-01 00:00:00

  • Discrimination between apo and iron-loaded forms of transferrin by transferrin binding protein B and its N-terminal subfragment.

    abstract：:Many pathogens of the Pasteurellaceae and Neisseriaceae possess a surface receptor that binds transferrin (Tf) as an initial step in an iron acquisition process. This receptor is comprised of two proteins, transferrin binding protein A (TbpA) and transferrin binding protein B (TbpB). Since the ability to recognize the...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1998.0226

    authors： Retzer MD,Yu Rh,Zhang Y,Gonzalez GC,Schryvers AB

    更新日期：1998-10-01 00:00:00

  • Influence of a 70 kilobase virulence plasmid on the ability of Yersinia enterocolitica to survive phagocytosis in vitro.

    abstract：:During the course of infection, Yersinia enterocolitica invades tissues where macrophages and polymorphonuclear leucocytes (PMNs) constitute the first line of defence. As expression of virulence in Y. enterocolitica is governed in part by a c. 70 kilobase virulence plasmid (pYV), we investigated the influence of this ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(92)90018-j

    authors： Tabrizi SN,Robins-Browne RM

    更新日期：1992-09-01 00:00:00

  • Evidence for group A-related M protein genes in human but not animal-associated group G streptococcal pathogens.

    abstract：:Group G streptococci have on their surface antiphagocytic M protein-like antigens. To determine if these organisms have genes similar to the M protein genes of Streptococcus pyogenes (group A), DNA from independent group G isolates of human and animal origin were tested for homology to probes representing sequences en...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(87)90004-0

    authors： Simpson WJ,Robbins JC,Cleary PP

    更新日期：1987-11-01 00:00:00

  • South Indian medicinal plants can combat deadly viruses along with COVID-19? - A review.

    abstract：:SARS-CoV-2 is a causative agent of Coronavirus disease-19 (COVID-19), which is considered as a fatal disease for public health apprehension worldwide. This pathogenic virus can present everywhere. As it is a virus it can extend easily and cause severe illness to humans. Hence, an efficient international attentiveness ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104277

    authors： Divya M,Vijayakumar S,Chen J,Vaseeharan B,Durán-Lara EF

    更新日期：2020-11-01 00:00:00

  • Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity.

    abstract：:Neisseria meningitidis is normally a human nasopharyngeal commensal but is also capable of causing life-threatening sepsis and meningitis. N. meningitidis secretes several virulence-associated proteins including Neisserial autotransporter lipoprotein (NalP), an immunogenic, type Va autotransporter harboring an S8-fami...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.08.001

    authors： Dufailu OA,Mahdavi J,Ala'Aldeen DAA,Wooldridge KG,Oldfield NJ

    更新日期：2018-11-01 00:00:00

  • Sulphate-reducing bacteria from ulcerative colitis patients induce apoptosis of gastrointestinal epithelial cells.

    abstract：:The human microbiome consists of a multitude of bacterial genera and species which continuously interact with one another and their host establishing a metabolic equilibrium. The dysbiosis can lead to the development of pathology, such as inflammatory bowel diseases. Sulfide-producing prokaryotes, including sulphate-r...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.09.054

    authors： Coutinho CMLM,Coutinho-Silva R,Zinkevich V,Pearce CB,Ojcius DM,Beech I

    更新日期：2017-11-01 00:00:00

  • Production and characterization of monoclonal antibodies against GII.6 norovirus virus-like particles.

    abstract：:In this study we generated and characterized a series of monoclonal antibodies (mAbs) against GII.6 norovirus (NoV) virus like particles (VLPs). Mice were immunized with purified GII.6 NoV VLPs and peptide-bovine serum albumin (BSA) conjugates with the peptide sequence (31 aa) derived from the trypsin cleavage region....

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104100

    authors： Qiu S,Zheng L,Qin C,Yin X,Ma J,Liu J,Yang Z,Li C,Wang Y,Wang M,Qi Y,Huo Y

    更新日期：2020-02-26 00:00:00

  • Adhesiveness of opportunistic Staphylococcus aureus to materials used in dental office: In vitro study.

    abstract：:Staphylococcus aureus (S. aureus) is one of several opportunistic microbial pathogens associated with many healthcare problems. In the present study, S. aureus was assessed for its biofilm-forming ability on materials routinely used in dental offices, including stainless steel (SS), polyethylene (PE), and polyvinyl ch...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.12.014

    authors： Merghni A,Bekir K,Kadmi Y,Dallel I,Janel S,Bovio S,Barois N,Lafont F,Mastouri M

    更新日期：2017-02-01 00:00:00

  • Intracellular signalling and cytoskeletal rearrangement involved in Yersinia pestis plasminogen activator (Pla) mediated HeLa cell invasion.

    abstract：:Yersinia pestis, the etiologic agent of plague is a highly invasive organism being able to invade non-phagocytic epithelial cells. Its plasminogen activator (Pla), encoded by the pPCP1 plasmid plays a pivotal role in internalisation of bacteria by HeLa cells. The aim of this study was to analyse the intracellular sign...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2004.04.001

    authors： Benedek O,Nagy G,Emody L

    更新日期：2004-07-01 00:00:00

  • Construction of a rhamnose mutation in Bacillus anthracis affects adherence to macrophages but not virulence in guinea pigs.

    abstract：:Carbohydrate analyses of whole-spore extracts have confirmed the presence of rhamnose in the spore of the fully virulent Ames strain of Bacillus anthracis. A gene cluster containing loci with high homology to the rhamnose biosynthetic genes, rmlACBD, was identified within the B. anthracis chromosome. The first gene of...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2004.10.001

    authors： Bozue JA,Parthasarathy N,Phillips LR,Cote CK,Fellows PF,Mendelson I,Shafferman A,Friedlander AM

    更新日期：2005-01-01 00:00:00

  • Gene expression signatures characterizing the development of lymphocyte response during experimental Chlamydia pneumoniae infection.

    abstract：:In this study experimental mouse model for Chlamydia pneumoniae infection was used to elucidate the nature of immune response developing during primary and secondary infection. First we examined the mononuclear cells from different lymphoid organs in BALB/c mice during C. pneumoniae infection and detected a strong lym...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2009.01.006

    authors： Kyläniemi MK,Haveri A,Vuola JM,Puolakkainen M,Lahesmaa R

    更新日期：2009-05-01 00:00:00

  • Potentiation of antibiotic activity of aminoglycosides by natural products from Cordia verbenacea DC.

    abstract：:Medicinal plants are often the only therapeutic resource for many communities and ethnic groups. Cordia verbenacea DC., "Erva-baleeira," is one of the species of plants currently used to produce a phytotherapeutic product extracted from its leaves. The present study aimed to establish its chemical profile, antibacteri...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.03.009

    authors： Matias EFF,Alves EF,Silva MKN,Carvalho VRA,Medeiros CR,Santos FAV,Bitu VCN,Souza CES,Figueredo FG,Boligon AA,Athayde ML,Costa JGM,Coutinho HDM

    更新日期：2016-06-01 00:00:00

  • The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus.

    abstract：:An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by insertional mutagenesis, and the MdaB protein was purified and compared to the Helicobacter pylori enzyme. While wild type H. hepaticus cells could tolerate 6% O(2) for growth, the mdaB strain was cle...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2006.08.005

    authors： Hong Y,Wang G,Maier RJ

    更新日期：2008-02-01 00:00:00

  • Transcriptional analysis reveals the relativity of acid tolerance and antimicrobial peptide resistance of Salmonella.

    abstract：:The objective of this study was to comprehensively identify the target genes induced by acid stimulation in Salmonella, and to clarify the relativity of acid tolerance and antimicrobial peptide resistance. A clinical S. Typhimurium strain, S6, was selected and performed a transcriptome analysis under the acid toleranc...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103701

    authors： Cao L,Wang J,Sun L,Kong Z,Wu Q,Wang Z

    更新日期：2019-11-01 00:00:00

  • Molecular detection and genetic characterization of the potentially pathogenic Coxiella burnetii and the endosymbiotic Candidatus Midichloria mitochondrii in ticks infesting camels (Camelus dromedarius) from Tunisia.

    abstract：:Tick-borne bacteria are considered to be emerging in camels, but data about their occurrence in Tunisian dromedaries and their infesting ticks remain scarce. In this study, 412 camel blood samples and 327 partially engorged ticks were collected and tested for the presence of Coxiella burnetii and/or related strains, a...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103655

    authors： Selmi R,Ben Said M,Mamlouk A,Ben Yahia H,Messadi L

    更新日期：2019-11-01 00:00:00

  • Sensitivity of Coriandrum sativum extract on bacterial pathogens isolated from digestive system of rabbits, and its role on in vitro cecal gas production and fermentation.

    abstract：:The present context was aimed to investigate the antibacterial potency of aqueous extract of coriander (Coriandrum sativum L.) leaves against bacterial pathogens isolated from the organs associated with digestive system of rabbit. This study also evaluated the influence of varied doses of aqueous extract of C. sativum...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.06.020

    authors： Mariezcurrena-Berasain MA,Velázquez-Garduño G,Marín-Mendoza PM,Pliego AB,Vega Castillo LF,Carranza BV,Khusro A,Ugbogu EA,Salem AZM

    更新日期：2018-10-01 00:00:00

  • Antibacterial and anti-biofilm activities of cinnamaldehyde against S. epidermidis.

    abstract：:The search for new antimicrobial drugs has been necessary due to the increased bacterial resistance to antibiotics currently in use, and natural products play an important role in this field. The aim of this study was to evaluate the in vitro effect of cinnamaldehyde on S. epidermidis strains, biofilm set-up preventio...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.11.009

    authors： Albano M,Crulhas BP,Alves FCB,Pereira AFM,Andrade BFMT,Barbosa LN,Furlanetto A,Lyra LPDS,Rall VLM,Júnior AF

    更新日期：2019-01-01 00:00:00

  • Effect of immunosuppression on pathogenesis of peste des petits ruminants (PPR) virus infection in goats.

    abstract：:In this study an attempt to address the effects of immunosuppression on pathogenesis of peste des petits ruminants (PPR) virus infection was undertaken. Cyclophosphamide and dexamethasone were used to immunosuppress the animals. The drug treated animals exhibited severe leukopaenia and lymphopaenia; one of the indicat...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2012.01.003

    authors： Jagtap SP,Rajak KK,Garg UK,Sen A,Bhanuprakash V,Sudhakar SB,Balamurugan V,Patel A,Ahuja A,Singh RK,Vanamayya PR

    更新日期：2012-04-01 00:00:00

  • Receptor affinity, stability and binding mode of Shiga toxins are determinants of toxicity.

    abstract：:The closely related Shiga toxins, Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), can bind to Gb3 receptors. However, Stx2-producing enterohemorrhagic Escherichia coli (EHEC) strains are more commonly associated with serious human disease (viz., hemolytic-uremic syndrome) than Stx1-producing strains. To clarify the rel...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2007.04.003

    authors： Shimizu T,Sato T,Kawakami S,Ohta T,Noda M,Hamabata T

    更新日期：2007-08-01 00:00:00

  • Nanoparticles and their antimicrobial properties against pathogens including bacteria, fungi, parasites and viruses.

    abstract：:In recent year, propagation and resistance of pathogenic microorganisms (bacteria, fungi and virals) to common antimicrobial agents has led to serious health and food problems. Today, nanotechnology science and nanoparticles (NPs) have been identified as a new approach to deal with this problem because of their inhere...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2018.08.008

    authors： Khezerlou A,Alizadeh-Sani M,Azizi-Lalabadi M,Ehsani A

    更新日期：2018-10-01 00:00:00

  • Evaluation of phytochemical analysis and antimicrobial activities Allium essential oil against the growth of some microbial pathogens.

    abstract：:In this experimental study, the Allium essential oil (AHEO) was extracted through the hydrodistillation method. AHEO components were identified through gas chromatography/mass spectrometry (GC/MS), and its antioxidant properties and total phenolic content were examined through the methods of 2,2-diphenyl-1-picrylhydra...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.11.055

    authors： Alizadeh Behbahani B,Imani Fooladi AA

    更新日期：2018-01-01 00:00:00