Analysis of the interaction of group A streptococci with fibrinogen, streptokinase and plasminogen.

Abstract:

:Group A streptococci demonstrate a number of distinct ways to interact with the human fibrinolytic system to acquire unregulatable cell-surface enzymatic activity. Interactions between bacteria, fibrinogen, streptokinase and plasminogen resulted in acquisition of cell-associated enzymatic activity that can lyse fibrin clots despite the presence of the major physiological plasmin inhibitor, alpha 2-antiplasmin. Western blot analysis of extracted streptococcal surface proteins suggested that binding of fibrinogen to M or M-related proteins mediated the capture of streptokinase-plasminogen complexes to the bacteria. The enzymatic complex formed by reaction of bacteria with fibrinogen, streptokinase and plasminogen was found to be more stable in human plasma than pre-formed plasmin bound directly to the same bacteria strain.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Wang H,Lottenberg R,Boyle MD

doi

10.1016/s0882-4010(95)90013-6

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

153-66

issue

3

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(95)90013-6

journal_volume

18

pub_type

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