Binding of Haemophilus ducreyi to extracellular matrix proteins.

Abstract:

:A collection of Haemophilus ducreyi isolates were screened for the ability to bind to fibrinogen, fibronectin, collagen, gelatin and laminin by a particle agglutination test using latex beads coated with the individual proteins. Thirteen of 21 isolates reacted with all five extracellular matrix proteins. Binding of organisms to protein-coated latex beads was inhibited by pretreatment of the bacteria with detergent, trypsin or boiling. Two isolates did not bind to collagen and gelatin with one of these not reacting with laminin either. Seven strains which failed to react with laminin did not express pili when examined by electron microscopy. This observation suggests a specific interaction with the pili of H. ducreyi.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Abeck D,Johnson AP,Mensing H

doi

10.1016/0882-4010(92)90034-l

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

81-4

issue

1

eissn

0882-4010

issn

1096-1208

pii

0882-4010(92)90034-L

journal_volume

13

pub_type

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