Host-directed therapies to combat tuberculosis and associated non-communicable diseases.

abstract：:Many pathogens of the Pasteurellaceae and Neisseriaceae possess a surface receptor that binds transferrin (Tf) as an initial step in an iron acquisition process. This receptor is comprised of two proteins, transferrin binding protein A (TbpA) and transferrin binding protein B (TbpB). Since the ability to recognize the...

journal_title：Microbial pathogenesis

authors： Retzer MD,Yu Rh,Zhang Y,Gonzalez GC,Schryvers AB

更新日期：1998-10-01 00:00:00

abstract：:As one of the dominant bacteria in the ocean, Vibrio play important roles in maintaining the aquatic ecosystem. In this study, we studied the phylogenetic relationships of 32 Vibrio based on the 16S rRNA genes sequences and utilized substrate immersing zymography method to detect the trend of protease production and c...

journal_title：Microbial pathogenesis

authors： Liu D,Wu C,Wu R,Huang J,Liao B,Lei M,Zhang Y,He H

更新日期：2019-06-01 00:00:00

abstract：:The antimicrobial properties of morel compounds from wild edible mushrooms (Morchella esculenta and Verpa bohemica) from Kashmir valley was investigated against different clinical pathogens. The butanol crude fraction of most popular or true morel M. esculenta showed highest 19 mm IZD against E.coli while as same frac...

journal_title：Microbial pathogenesis

authors： Shameem N,Kamili AN,Ahmad M,Masoodi FA,Parray JA

更新日期：2017-04-01 00:00:00

abstract：:The human microbiome consists of a multitude of bacterial genera and species which continuously interact with one another and their host establishing a metabolic equilibrium. The dysbiosis can lead to the development of pathology, such as inflammatory bowel diseases. Sulfide-producing prokaryotes, including sulphate-r...

journal_title：Microbial pathogenesis

authors： Coutinho CMLM,Coutinho-Silva R,Zinkevich V,Pearce CB,Ojcius DM,Beech I

更新日期：2017-11-01 00:00:00

abstract：:Mannheimia(Pasteurella)haemolytica serotype 1 is the primary causative agent responsible for bovine pneumonic mannheimiosis, also known as shipping fever in cattle. The bacterium produces a variety of virulence factors, foremost of which is the exotoxic leukotoxin. The leukotoxin is a calcium-dependent cytolysin that ...

journal_title：Microbial pathogenesis

authors： Thumbikat P,Briggs RE,Kannan MS,Maheswaran SK

更新日期：2003-05-01 00:00:00

abstract：:Corynebacterium pseudotuberculosis produces a sphingomyelin-specific phospholipase D exotoxin that is a major determinant in the pathogenesis of caseous lymphadenitis. We assessed the changes induced in the morphology and sphingomyelin concentration of ovine erythrocytes after incubation with broth culture filtrates o...

journal_title：Microbial pathogenesis

authors： Brogden KA,Engen RL,Songer JG,Gallagher J

更新日期：1990-02-01 00:00:00

abstract：:Intravenous inoculation of Swiss mice with S. aureus leads to severe synovial joint tissue swelling along with prominent T lymphocyte infiltrate with associated inflammation in synovial tissue. Cytokines released from macrophages such as TNF-α, IL-1β and IL-6 the main players that precede cartilage and bone destructio...

journal_title：Microbial pathogenesis

authors： Dey I,Bishayi B

更新日期：2017-12-01 00:00:00

abstract：:Repetitive tetranucleotide sequences of 5'-(CAAT)(n)-3' have been identified at the 5' end of an open reading frame (ORF) named lob1 from Haemophilus somnus strain 738. Based on sequence analysis, lob1 has 59% DNA homology to lex2B, which is involved in lipooligosaccharide (LOS) biosynthesis in H. influenzae. We now r...

journal_title：Microbial pathogenesis

authors： McQuiston JH,McQuiston JR,Cox AD,Wu Y,Boyle SM,Inzana TJ

更新日期：2000-05-01 00:00:00

abstract：:Our earlier studies showed that AhyRI- (AI-1) and LuxS-based (AI-2) quorum sensing (QS) systems were positive and negative regulators of virulence, respectively, in a diarrheal isolate SSU of Aeromonas hydrophila. Recently, we demonstrated that deletion of the QseBC two-component signal transduction system (AI-3 QS in...

journal_title：Microbial pathogenesis

authors： Kozlova EV,Khajanchi BK,Popov VL,Wen J,Chopra AK

更新日期：2012-09-01 00:00:00

abstract：:T lymphocyte-mediated immunity is important for resistance to Francisella tularensis. To characterize the specificity of this immunity, we used membrane proteins and two lipopolysaccharide (LPS) preparations. Both membrane proteins were heat-modifiable, as indicated by their migration in sodium dodecyl sulphate polyac...

journal_title：Microbial pathogenesis

authors： Surcel HM,Sarvas M,Helander IM,Herva E

更新日期：1989-12-01 00:00:00

abstract：:The re-emerging field of phage therapy is the potential biocontrol agents for the transfer of virulence factor and to kill their bacterial hosts. In this study, the lytic Vibrio vulnificus phages were studied to provide a better understanding of phage-host interactions and development of phage therapy. Four new V. vul...

journal_title：Microbial pathogenesis

authors： Srinivasan P,Ramasamy P

更新日期：2017-10-01 00:00:00

abstract：:Meningococci can be classified by the presence of serotype and subtype antigens on the class 2/3 and class 1 outer membrane proteins, respectively. A typing system employing monoclonal antibodies and a WCE for detection of such antigens enabled us to sero- and/or subtype 255 out of 268 group B meningococci from 19 cou...

journal_title：Microbial pathogenesis

authors： Abdillahi H,Poolman JT

更新日期：1988-01-01 00:00:00

abstract：:In order to characterize the toxicity of the hemorrhagic toxin of Clostridium sporogenes isolated from the rabbit with antibiotic-associated hemorrhagic diarrhoea, we studied the toxin productivity of C. sporogenes cultured in various media and the toxic effect of the partially purified preparation of the culture supe...

journal_title：Microbial pathogenesis

authors： Hara-Kudo Y,Ogura A,Noguchi Y,Terao K,Kumagai S

更新日期：1997-01-01 00:00:00

abstract：:Essential oils (EOs) obtained from aromatic plants are rich in natural components with interesting antimicrobial effects. The aim of this study was to evaluate the chemical composition of EOs extracted from Origanum majorana (OM-EO), Mentha suaveolens (MS-EO), Rosmarinus officinalis (RO-EO), Salvia officinalis (SO-EO)...

journal_title：Microbial pathogenesis

authors： Ed-Dra A,Filali FR,Lo Presti V,Zekkori B,Nalbone L,Bouymajane A,Trabelsi N,Lamberta F,Bentayeb A,Giuffrida A,Giarratana F

更新日期：2020-12-01 00:00:00

abstract：:We analyzed here the complete genome sequences of a highly virulent Flavobacterium columnare Pf1 strain isolated in our laboratory. The complete genome consists of a 3,171,081 bp circular DNA with 2784 predicted protein-coding genes. Among these, 286 genes were predicted as antibiotic resistance genes, including 32 RN...

journal_title：Microbial pathogenesis

authors： Zhang Y,Zhao L,Chen W,Huang Y,Yang L,Sarathbabu V,Wu Z,Li J,Nie P,Lin L

更新日期：2017-10-01 00:00:00

abstract：:Hemolysins are cytolytic proteins which have been extensively characterized at the molecular level, however, their in vivo functions remain unclear. This study analyzed the association of hemolysin production with the inflammatory response in patients with urinary tract infection (UTI). Infants and children with their...

journal_title：Microbial pathogenesis

authors： Connell H,de Man P,Jodal U,Lincoln K,Svanborg C

更新日期：1993-06-01 00:00:00

abstract：:Acanthamoeba are free-living, harmless organisms, however, given the opportunity and the appropriate conditions, they can cause painful, sight-threatening as well as fatal infections and, thus, are considered opportunistic pathogens. Acanthamoeba infections have become increasingly important in the past few years due ...

journal_title：Microbial pathogenesis

authors： Khan NA

更新日期：2003-06-01 00:00:00

abstract：:The search for new antimicrobial drugs has been necessary due to the increased bacterial resistance to antibiotics currently in use, and natural products play an important role in this field. The aim of this study was to evaluate the in vitro effect of cinnamaldehyde on S. epidermidis strains, biofilm set-up preventio...

journal_title：Microbial pathogenesis

authors： Albano M,Crulhas BP,Alves FCB,Pereira AFM,Andrade BFMT,Barbosa LN,Furlanetto A,Lyra LPDS,Rall VLM,Júnior AF

更新日期：2019-01-01 00:00:00

abstract：:This paper describes the development of a murine bank of monoclonal antibodies against Bordetella pertussis toxin, filamentous hemagglutinin (FHA), pili, lipopolysaccharide (LPS), or outer membrane proteins (OMPs). Subunits S1, S2, S3 of pertussis toxin (PT) bound immunoglobulins and glycoproteins such as fetuin and h...

journal_title：Microbial pathogenesis

authors： Poolman JT,Kuipers B,Vogel ML,Hamstra HJ,Nagel J

更新日期：1990-06-01 00:00:00

abstract：:Recent research has shown broad antifungal activity of the classic antidepressants selective serotonin reuptake inhibitors (SSRIs). This fact, combined with the increased cross-resistance frequency of the genre Candida regarding the main treatment today, fluconazole, requires the development of novel therapeutic strat...

journal_title：Microbial pathogenesis

authors： Costa Silva RA,da Silva CR,de Andrade Neto JB,da Silva AR,Campos RS,Sampaio LS,do Nascimento FBSA,da Silva Gaspar B,da Cruz Fonseca SG,Josino MAA,Grangeiro TB,Gaspar DM,de Lucena DF,de Moraes MO,Cavalcanti BC,Nobre Júnior H

更新日期：2017-06-01 00:00:00

abstract：:This study aimed to isolate and demonstrate their antioxidant and immunostimulatory activities of potential probiotics. The isolated strains, S. Pum19, SC28, and SC61 showed potential probiotic properties including stability in artificial gastric and bile conditions, non-production of β-glucuronidase, suitable antibio...

journal_title：Microbial pathogenesis

authors： Son SH,Yang SJ,Jeon HL,Yu HS,Lee NK,Park YS,Paik HD

更新日期：2018-12-01 00:00:00

abstract：:A diarrheal isolate SSU of Aeromonas hydrophila produces a cytotoxic enterotoxin (Act) with cytotoxic, enterotoxic, and hemolytic activities. Our laboratory has characterized from the above Aeromonas strain, in addition to Act, the type 3- and T6-secretion systems and their effectors, as well as the genes shown to mod...

journal_title：Microbial pathogenesis

authors： Kozlova EV,Popov VL,Sha J,Foltz SM,Erova TE,Agar SL,Horneman AJ,Chopra AK

更新日期：2008-11-01 00:00:00

abstract：:Staphylococcus aureus small-colony variants (SCVs) and biofilms are linked to chronic infections. It is known that the presence of aminoglycoside antibiotics may contribute to the emergence of SCVs and it is thought that molecular mechanisms are involved in the ability of S. aureus to adopt this phenotype. No study ha...

journal_title：Microbial pathogenesis

authors： Mitchell G,Brouillette E,Séguin DL,Asselin AE,Jacob CL,Malouin F

更新日期：2010-01-01 00:00:00

abstract：:Pathogenic Salmonella strains have a set of virulence factors allowing them to generate systemic infections and damage in a variety of hosts. Among these factors, bacterial proteins secreted by specialized systems are used to penetrate the host's intestinal mucosa, through the invasion and destruction of specialized e...

journal_title：Microbial pathogenesis

authors： Varas M,Ortíz-Severín J,Marcoleta AE,Díaz-Pascual F,Allende ML,Santiviago CA,Chávez FP

更新日期：2017-06-01 00:00:00

abstract：:NorA, NorB, and NorC are efflux proteins in the Nor family that regulate the secretion of fluoroquinolones, and MgrA/NorR is a transcription factor of the Nor family. Overexpression of Nor family proteins provides fluoroquinolone resistance in Staphylococcus aureus. However, in coagulase-negative staphylococci (CNS), ...

journal_title：Microbial pathogenesis

authors： Juárez-Verdayes MA,Parra-Ortega B,Hernández-Rodríguez C,Betanzos-Cabrera G,Rodríguez-Martínez S,Cancino-Diaz ME,Cancino-Diaz JC

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Blastocystis is one of the most common pathogens of the human intestine, caused by an emerging parasite, which can lead to severe symptoms and even death in immunocompromised patients. We aimed to determine the global prevalence of Blastocystosis infection in people with immunodeficiency. A systematic litera...

journal_title：Microbial pathogenesis

authors： Khorshidvand Z,Khazaei S,Amiri M,Taherkhani H,Mirzaei A

更新日期：2020-11-24 00:00:00

abstract：:Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are two major omega-3 polyunsaturated fatty acids (n-3 PUFAs) with antimicrobial properties. In this study, we evaluated the potential antibacterial and antibiofilm activities of DHA and EPA against two periodontal pathogens, Porphyromonas gingivalis (P. gingi...

journal_title：Microbial pathogenesis

authors： Sun M,Zhou Z,Dong J,Zhang J,Xia Y,Shu R

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Cronobacter spp. are Gram-negative, facultative-anaerobic, non-spore forming, enteric coliform bacteria, which belongs to the Enterobacteriaceae family. Cronobacter spp. are opportunistic pathogens that have brought rare but life-threatening infections such as meningitis, necrotizing enterocolitis and bloods...

journal_title：Microbial pathogenesis

authors： Holý O,Cruz-Córdova A,Xicohtencatl-Cortes J,Hochel I,Parra-Flores J,Petrželová J,Fačevicová K,Forsythe S,Alsonosi A

更新日期：2019-02-01 00:00:00

abstract：:Mycoplasma pneumoniae (M. pneumoniae) is a small bacterium characterized by the absence of cell wall. It is a human pathogen causing upper and lower respiratory infections, both in adults and children. However, it is also considered to be implicated in the pathogenesis of several types of extra-respiratory diseases, i...

journal_title：Microbial pathogenesis

authors： Poddighe D

更新日期：2020-02-01 00:00:00

abstract：:J subgroup avian leukosis virus (ALV-J) is an exogenous retrovirus of avian. A key feature of ALV-J infection is leading to severe immunosuppressive characteristic of diseases. Viral components of retrovirus were reported closely associated with immunosuppression, and several similarities between exosomes and retrovir...

journal_title：Microbial pathogenesis

authors： Wang G,Wang Z,Zhuang P,Zhao X,Cheng Z

更新日期：2017-11-01 00:00:00