Neisseria meningitidis group B serosubtyping using monoclonal antibodies in whole-cell ELISA.

Abstract:

:Meningococci can be classified by the presence of serotype and subtype antigens on the class 2/3 and class 1 outer membrane proteins, respectively. A typing system employing monoclonal antibodies and a WCE for detection of such antigens enabled us to sero- and/or subtype 255 out of 268 group B meningococci from 19 countries collected from 1959 till 1987. The combination of a comprehensive collection of antibodies and a sensitive, specific, large-scale screening technique greatly facilitates the assignment of bacterial isolates to their sero- or subtype. This will then allow definitive, bass-line information on the epidemiology of meningococci and on the possible construction of outer membrane protein vaccines.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Abdillahi H,Poolman JT

doi

10.1016/0882-4010(88)90045-9

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

27-32

issue

1

eissn

0882-4010

issn

1096-1208

pii

0882-4010(88)90045-9

journal_volume

4

pub_type

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