当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > Regulation of NF-κB/MAPK signaling pathway attenuates the acute lung inflammation in Klebsiella pneumonia rats by mollugin treatment.

Regulation of NF-κB/MAPK signaling pathway attenuates the acute lung inflammation in Klebsiella pneumonia rats by mollugin treatment.

Abstract：

:Present study evaluates the protective effect of mollugin against Klebsiella pneumonia (KP) and also postulates the possible mechanism of its action. Klebsiella pneumoniae (2.4 × 108 CFU/ml) was used for the induction of KP. PMNs and WBC count was determined in the blood and bronchoalveolar lavage fluid (BALF) of Klebsiella pneumonia rat. Level of inflammatory cytokines in the blood of Klebsiella pneumonia rat was determined by ELISA methods. Moreover effect of mollugin was estimated by Western blot assay and RT-PCR method. Result of the study suggests that water content in lung was reduced in the mollugin treated group compared to pneumonia control group of rats. Count of PMNs and WBC were found to be reduced in mollugin treated group compared to pneumonia control group of rats. Level of inflammatory cytokines was also found to be reduced in the blood of mollugin treated group than pneumonia control group. Moreover treatment with mollugin attenuates the altered expression of p-MAPK, p-JNK and p-ERK protein and mRNA expression of NF-κB in the lung tissues of Klebsiella pneumonia rat. In conclusion, data of the study reveals that treatment with mollugin ameliorates Klebsiella pneumonia rat by reducing the lung inflammation. Inflammation of lung tissue was reduced by regulating the NF-κB/MAPK signaling pathway in mollugin treated group.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Zhang Y,Zhou S,Zhou J,Wang D,Zhou T

doi

10.1016/j.micpath.2019.05.007

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

369-373

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(19)30747-8

journal_volume

132

pub_type

杂志文章

相关文献

MICROBIAL PATHOGENESIS文献大全
  • Characterization of rickettsial adhesin Adr2 belonging to a new group of adhesins in α-proteobacteria.

    abstract：BACKGROUND:Rickettsia prowazekii is the etiological agent of epidemic typhus and is an obligate intracellular bacterium that grows as a parasite freely within the cytoplasm of a eukaryotic host cell. Previous studies have shown that rOmpA and rOmpB which belong to the family of rickettsial cell surface antigens are inv...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2011.01.009

    authors： Vellaiswamy M,Kowalczewska M,Merhej V,Nappez C,Vincentelli R,Renesto P,Raoult D

    更新日期：2011-05-01 00:00:00

  • Integrons in uropathogenic Escherichia coli and their relationship with phylogeny and virulence.

    abstract：:Uropathogenic Escherichia coli (UPEC) comprise a heterogeneous group of strains. In a previous epidemiological survey performed on 230 UPEC isolates, five virulence profiles were described, each one defined by the presence of some virulence determinants and by the absence of others. Phylogenetic groups and antibiotic ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2014.11.002

    authors： Poey ME,Laviña M

    更新日期：2014-12-01 00:00:00

  • Differences in pathogenicity and virulence-associated gene expression among Pasteurella multocida strains with high and low virulence in a lung tissue model.

    abstract：:Pasteurella multocida capsular type A can cause a pulmonary infection, leading to serious pecuniary losses in cattle. The heterogeneity of infection outcome of P. multocida strains showing different virulence may be related to divergent expression of virulence genes. In this study, we compared the transcriptional resp...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103911

    authors： Cheng Y,Wang K,Lin L,Zhao X,Pan Z,Zhou Z

    更新日期：2020-03-01 00:00:00

  • The complete genome sequence of Bacillus halotolerans ZB201702 isolated from a drought- and salt-stressed rhizosphere soil.

    abstract：:Bacillus halotolerans is a rhizobacterium with the potential to promote plant growth and tolerance to drought and salinity stress. Here, we present the complete genome sequence of B. halotolerans ZB201702, which consists of 4,150,000 bp in a linear chromosome, including 3074 protein-coding sequences, 30 rRNAs, and 85 ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.07.019

    authors： Zhang Z,Yin L,Li X,Zhang C,Liu C,Wu Z

    更新日期：2018-10-01 00:00:00

  • The role of O1-antigen in the adhesion to uroepithelial cells of Klebsiella pneumoniae grown in urine.

    abstract：:We obtained mutants devoid of the O1-antigen, the capsular polysaccharide (K antigen) or both from Klebsiella pneumoniae clinical isolates (urinary infection). These mutants were grown in urine, and their ability to fimbriate and to adhere were studied. Mutants lacking the O1-antigen, independently of the other surfac...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1997.0132

    authors： Merino S,Rubires X,Aguilar A,Tomás JM

    更新日期：1997-07-01 00:00:00

  • Genetic organization of the she pathogenicity island in Shigella flexneri 2a.

    abstract：:In this study we report the complete nucleotide sequence and genetic organization of the she pathogenicity island (PAI) of Shigella flexneri 2a strain YSH6000T. The 46 603 bp she PAI is situated adjacent to the 3' terminus of the pheV tRNA gene and includes an imperfect direct repeat of the 3'-terminal 22 bp of the ph...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0404

    authors： Al-Hasani K,Rajakumar K,Bulach D,Robins-Browne R,Adler B,Sakellaris H

    更新日期：2001-01-01 00:00:00

  • Evaluation of culture conditions for mixed biofilm formation with clinically isolated non-albicans Candida species and Staphylococcus epidermidis on silicone.

    abstract：:Silicone is frequently used in clinical and medical fields for medical devices. Mixed biofilms composed of Candida and bacterial species causes frequently failure of medical silicone devices, In this in vitro study, we analyzed mixed biofilm formation of clinically isolated non-albicans Candida species and Staphylococ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.10.002

    authors： Tan Y,Leonhard M,Schneider-Stickler B

    更新日期：2017-11-01 00:00:00

  • Sensitivity of Coriandrum sativum extract on bacterial pathogens isolated from digestive system of rabbits, and its role on in vitro cecal gas production and fermentation.

    abstract：:The present context was aimed to investigate the antibacterial potency of aqueous extract of coriander (Coriandrum sativum L.) leaves against bacterial pathogens isolated from the organs associated with digestive system of rabbit. This study also evaluated the influence of varied doses of aqueous extract of C. sativum...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.06.020

    authors： Mariezcurrena-Berasain MA,Velázquez-Garduño G,Marín-Mendoza PM,Pliego AB,Vega Castillo LF,Carranza BV,Khusro A,Ugbogu EA,Salem AZM

    更新日期：2018-10-01 00:00:00

  • Activated mouse macrophages kill Entamoeba histolytica trophozoites by releasing reactive nitrogen intermediates.

    abstract：:Mouse macrophages activated by gamma interferon (IFN-gamma) and bacterial lipopolysaccharide (LPS) are highly cytotoxic for the enteric protozoan parasite Entamoeba histolytica. Herein, we show that this killing by activated macrophages is L-arginine dependent, inasmuch as it was blocked by exogenous arginase or NG-mo...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(92)90053-q

    authors： Denis M,Ghadirian E

    更新日期：1992-03-01 00:00:00

  • Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection.

    abstract：:The involvement of nitric oxide (NO) in host defense and cytoprotective functions in murine salmonellosis has been reported. Salmonella mutants with the altered sigma factor RpoS (sigmaS) are less virulent and are susceptible to various stresses. This study investigated the role of the rpoS gene of Salmonella enterica...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2005.11.007

    authors： Alam MS,Zaki MH,Yoshitake J,Akuta T,Ezaki T,Akaike T

    更新日期：2006-03-01 00:00:00

  • IL-10 regulate decidual Tregs apoptosis contributing to the abnormal pregnancy with Toxoplasma gondii infection.

    abstract：:This study aims to investigate whether IL-10 regulate decidual Treg cells apoptosis to reverse the abnormal pregnancy outcomes with Toxoplasma gondii (T. gondii) infection. Recombinant mouse IL-10 (rIL-10) treatment and IL-10 deficiency (IL-10(-/-)) abnormal pregnancy animal models with T. gondii infection were establ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2015.10.002

    authors： Lao K,Zhao M,Li Z,Liu X,Zhang H,Jiang Y,Wang Y,Hu X

    更新日期：2015-12-01 00:00:00

  • Analysis of the influence of living environment and age on vaginal fungal microbiome in giant pandas (Ailuropoda melanoleuca) by high throughput sequencing.

    abstract：:A recent study has described the normal vaginal bacterial community in giant pandas, but there is a lack of knowledge of the fungal community residing in the vagina of giant pandas. In order to comprehensively understand the vaginal fungal microbial diversity and abundance in giant pandas, high throughput sequencing w...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.12.067

    authors： Chen D,Li C,Feng L,Zhang Z,Zhang H,Cheng G,Li D,Zhang G,Wang H,Chen Y,Feng M,Wang C,Wu H,Deng L,Ming H,Yang X

    更新日期：2018-02-01 00:00:00

  • Principle component analysis (PCA) for investigation of relationship between population dynamics of microbial pathogenesis, chemical and sensory characteristics in beef slices containing Tarragon essential oil.

    abstract：:Principle component analysis (PCA) was employed to examine the effect of the exerted treatments on the beef shelf life as well as discovering the correlations between the studied responses. Considering the variability of the dimensions of the responses, correlation coefficients were applied to form the matrix and extr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.02.013

    authors： Alizadeh Behbahani B,Tabatabaei Yazdi F,Shahidi F,Mortazavi SA,Mohebbi M

    更新日期：2017-04-01 00:00:00

  • Acute and late disease induced by murine coronavirus, strain JHM, in a series of recombinant inbred strains between BALB/cHeA and STS/A mice.

    abstract：:To examine the genetic control of acute and late disease induced by a murine coronavirus, strain JHM (JHMV), BALB/cHeA, STS/A, F1 hybrids and 13 recombinant inbred (RI) strains between BALB/cHeA and STS/A mouse strains were inoculated intracerebrally with 100 pfu of JHMV. All the BALB/cHeA mice died within 2 weeks fro...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(92)90112-2

    authors： Kyuwa S,Yamaguchi K,Toyoda Y,Fujiwara K,Hilgers J

    更新日期：1992-02-01 00:00:00

  • Strategies and advancements in human microbiome description and the importance of culturomics.

    abstract：:The human microbiota gained a big interest among the scientific community with numerous studies being performed to better understand its role in health and diseases. Even with all the success achieved in studying the bacterial populations at the different body sites and its interaction among each other and with the ho...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104460

    authors： Bilen M

    更新日期：2020-12-01 00:00:00

  • Identification and characterization of the ribosome-associated protein, HrpA, of Bacillus Calmette-Guérin.

    abstract：:HrpA was found as a ribosome-associated protein which appeared in heat-stressed Mycobacterium bovis Bacillus Calmette-Guérin. Here, we have studied the function of HrpA in vitro. HrpA is a heat shock protein belonging to a small heat shock protein family. The putative molecular mass was 17784.86 kDa. Recombinant HrpA ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0384

    authors： Tabira Y,Ohara N,Yamada T

    更新日期：2000-10-01 00:00:00

  • Multiple-locus variable-number tandem repeat analysis (MLVA) for genotyping of Salmonella enterica subspecies enterica serotype Infantis isolated from human sources.

    abstract：:Salmonella is an important cause of food-borne infection worldwide. Detection of outbreaks caused by Salmonella spp. relies on suitable and robust methods for genotyping. Little is known about the genetic diversity of the Salmonella enterica subspecies enterica serotype Infantis strains isolated from human sources in ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.10.012

    authors： Ranjbar R,Ahmadi M,Memariani M

    更新日期：2016-11-01 00:00:00

  • Chlamydia pneumoniae infection in IL-10 knock out mice: accelerated clearance but severe pulmonary inflammatory response.

    abstract：:In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both e...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2008.02.004

    authors： Penttilä T,Haveri A,Tammiruusu A,Vuola JM,Lahesmaa R,Puolakkainen M

    更新日期：2008-07-01 00:00:00

  • Role of Th17 and Treg cells in septic arthritis and the impact of the Th17/Treg -derived cytokines in the pathogenesis of S. aureus induced septic arthritis in mice.

    abstract：:Intravenous inoculation of Swiss mice with S. aureus leads to severe synovial joint tissue swelling along with prominent T lymphocyte infiltrate with associated inflammation in synovial tissue. Cytokines released from macrophages such as TNF-α, IL-1β and IL-6 the main players that precede cartilage and bone destructio...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.10.033

    authors： Dey I,Bishayi B

    更新日期：2017-12-01 00:00:00

  • Cloning and molecular analysis of the Isi1 (rfaF) gene of Neisseria meningitidis which encodes a heptosyl-2-transferase involved in LPS biosynthesis: evaluation of surface exposed carbohydrates in LPS mediated toxicity for human endothelial cells.

    abstract：:Neisseria meningitidis, but not Haemophilus influenzae, damage cultured human endothelial cells. We have undertaken a study to generate genetically and structurally defined lipopolysaccharide (LPS) mutant strains of meningococci for functional studies to assess the role of surface exposed oligosaccharides in imparting...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1995.0074

    authors： Jennings MP,Bisercic M,Dunn KL,Virji M,Martin A,Wilks KE,Richards JC,Moxon ER

    更新日期：1995-12-01 00:00:00

  • Differential pathway network analysis used to identify key pathways associated with pediatric pneumonia.

    abstract：:We aimed to identify key pathways to further explore the molecular mechanism underlying pediatric pneumonia using differential pathway network which integrated protein-protein interactions (PPI) data and pathway information. PPI data and pathway information were obtained from STRING and Reactome database, respectively...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.10.023

    authors： Yang JB,Luo R,Yan Y,Chen Y

    更新日期：2016-12-01 00:00:00

  • Immunopathogenesis of infection with the visceralizing Leishmania species.

    abstract：:Human leishmaniasis is a spectral disease that includes asymptomatic self-resolving infection, localized skin lesions, and progressive visceral leishmaniasis. With some overlap, visceral and cutaneous leishmaniasis are usually caused by different species of Leishmania. This review focuses on host responses to infectio...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2004.11.002

    authors： Wilson ME,Jeronimo SM,Pearson RD

    更新日期：2005-04-01 00:00:00

  • Interaction of heat-stable enterotoxins with human colonic (T84) cells: modulation of the activation of guanylyl cyclase.

    abstract：:Heat-stable enterotoxins (ST) activate guanylyl cyclase in T84 cells, rapidly and specifically. Activation is monitored by cGMP production and occurs at lower concentrations of ST than required for eliciting fluid accumulation in suckling mice. Atrial natriuretic factor (ANF) neither activates guanylyl cyclase nor mod...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(92)90055-s

    authors： Visweswariah SS,Shanthi G,Balganesh TS

    更新日期：1992-03-01 00:00:00

  • Integrated transcriptomic and quantitative proteomic analysis identifies potential RNA sensors that respond to the Ag85A DNA vaccine.

    abstract：OBJECTIVE:DNA vaccine has emerged as a promising approach with potential for Tuberculosis (TB) prevention in adults. However, the mechanism behind DNA vaccines is still largely unknown. MATERIALS AND METHODS:Utilizing the CRISPR/Cas9 technique, we engineered Ag85A mutated dendritic cells (Ag85A-M-DCs) in which the Ag8...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2020.104487

    authors： Zhai J,Gao W,Zhao L,Lu C

    更新日期：2020-12-01 00:00:00

  • Antioxidant defense response induced by Trichoderma viride against Aspergillus niger Van Tieghem causing collar rot in groundnut (Arachis hypogaea L.).

    abstract：:The study was conducted to examine the antioxidant enzymes induced by Trichoderma viride JAU60 as initial defense response during invasion of rot pathogen Aspergillus niger Van Tieghem in five groundnut varieties under pot culture. Seed treatment of T. viride JAU60 reduced 51-58% collar rot disease incidence in differ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2015.11.010

    authors： Gajera HP,Katakpara ZA,Patel SV,Golakiya BA

    更新日期：2016-02-01 00:00:00

  • The 19-kDa antigen of Mycobacterium tuberculosis is a major adhesin that binds the mannose receptor of THP-1 monocytic cells and promotes phagocytosis of mycobacteria.

    abstract：:Identification of mycobacterial adhesins is needed to understand better the pathogenesis of tuberculosis and to develop new strategies to fight this infection. In this work, THP-1 monocytic cells were incubated with Mycobacterium tuberculosis culture filtrate proteins labelled with biotin and a dominant 19-kDa adhesin...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2005.06.002

    authors： Diaz-Silvestre H,Espinosa-Cueto P,Sanchez-Gonzalez A,Esparza-Ceron MA,Pereira-Suarez AL,Bernal-Fernandez G,Espitia C,Mancilla R

    更新日期：2005-09-01 00:00:00

  • Species and strain specificity of Lactobacillus probiotics effect on weight regulation.

    abstract：:Certain strains of Lactobacillus appear to have a reproducible effect on weight as a weight-gain effect in lean humans and animals or a weight-loss effect in overweight/obese humans and animals. These results are completely sufficient to capture the attention of the scientific community to assess the effect on the wei...

    journal_title：Microbial pathogenesis

    pub_type： 评论,信件

    doi：10.1016/j.micpath.2012.09.013

    authors： Million M,Raoult D

    更新日期：2013-02-01 00:00:00

  • Molecular prevalence of putative virulence-associated genes in Brucella melitensis and Brucella abortus isolates from human and livestock specimens in Iran.

    abstract：:Molecular prevalence of nine putative virulence factors in two more prevalent Brucella species in Iranian patients and livestock was investigated. During five years (2010-2015), 120 human and animal specimens were collected from three geographical areas of Iran. All samples were cultured in blood culture media and sub...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.03.007

    authors： Hashemifar I,Yadegar A,Jazi FM,Amirmozafari N

    更新日期：2017-04-01 00:00:00

  • Potentiation of antibiotic activity of aminoglycosides by natural products from Cordia verbenacea DC.

    abstract：:Medicinal plants are often the only therapeutic resource for many communities and ethnic groups. Cordia verbenacea DC., "Erva-baleeira," is one of the species of plants currently used to produce a phytotherapeutic product extracted from its leaves. The present study aimed to establish its chemical profile, antibacteri...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.03.009

    authors： Matias EFF,Alves EF,Silva MKN,Carvalho VRA,Medeiros CR,Santos FAV,Bitu VCN,Souza CES,Figueredo FG,Boligon AA,Athayde ML,Costa JGM,Coutinho HDM

    更新日期：2016-06-01 00:00:00

  • Peptides as adjuvants for ampicillin and oxacillin against methicillin-resistant Staphylococcus aureus (MRSA).

    abstract：:Fast emerging antibiotic resistance in pathogens requires special attention for strengthening the reservoir of antimicrobial compounds. In view of this, several peptides with known antimicrobial activities have been reported to enhance the efficacy of antibiotics against multidrug resistant (MDR) pathogens. In the pre...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.08.023

    authors： Rishi P,Vij S,Maurya IK,Kaur UJ,Bharati S,Tewari R

    更新日期：2018-11-01 00:00:00