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Differential expression of genes encoding membrane proteins between acute and continuous Chlamydia pneumoniae infections.

Abstract：

:Chlamydia pneumoniae is associated with several chronic human diseases, including chronic obstructive pulmonary disease and atherosclerotic cardiovascular disease. During chronic disease, organisms are believed to exist in a persistent phase that is not well understood at the genetic level. Long-term in vitro continuous infections are spontaneously persistent and are less susceptible than in vitro acute infections to treatment with antibiotics, and are therefore particularly relevant as an in vitro model of in vivo chronic disease. Real-time reverse transcriptase-PCR (r-t RT-PCR) was used to quantitate transcript copy numbers of 13 genes in continuous and acute infections with C. pneumoniae. The set of genes studied encodes proteins with known or predicted functions in the cell membrane, the inclusion membrane, cell division, metabolism, and immunopathology. Significant upregulation was seen for five genes (CPn0483, nlpD, ompA, pmp1 and porB) in continuous cultures. The genes omcB, pmp1, and porB, all of which encode membrane proteins, shared similar patterns of expression over both acute and continuous profiles. These results show that Chlamydia in the long-term continuous model of persistence have a unique transcription profile, adding to our knowledge of regulation of this important stage of chlamydial growth.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Hogan RJ,Mathews SA,Kutlin A,Hammerschlag MR,Timms P

doi

10.1016/s0882-4010(02)00187-0

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

11-6

issue

1

eissn

0882-4010

issn

1096-1208

pii

S0882401002001870

journal_volume

34

pub_type

杂志文章

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