Antibacterial studies of hydroxyspiro[indoline-3,9-xanthene]trione against spiro[indoline3,9-xanthene]trione and their use as acetyl and butyrylcholinesterase inhibitors.

abstract：INTRODUCTION:Pneumococcal infections have caused morbidity and mortality globally. Streptococcus pneumoniae (pneumococci) are commensal bacteria that colonize the nasopharynx, asymptomatically. From there, pneumococci can spread in the lungs causing pneumonia and disseminate in the bloodstream causing bacteremia (sepsi...

journal_title：Microbial pathogenesis

authors： Rahman NA,Sharudin A,Diah S,Muharram SH

更新日期：2017-09-01 00:00:00

abstract：:In this study we generated and characterized a series of monoclonal antibodies (mAbs) against GII.6 norovirus (NoV) virus like particles (VLPs). Mice were immunized with purified GII.6 NoV VLPs and peptide-bovine serum albumin (BSA) conjugates with the peptide sequence (31 aa) derived from the trypsin cleavage region....

journal_title：Microbial pathogenesis

authors： Qiu S,Zheng L,Qin C,Yin X,Ma J,Liu J,Yang Z,Li C,Wang Y,Wang M,Qi Y,Huo Y

更新日期：2020-02-26 00:00:00

abstract：:Mycobacterium avium complex (MAC) strains from AIDS and non-AIDS patients and from the environment were studied for their colony morphology and virulence in beige mice. The majority of the MAC isolates from AIDS patients, in contrast to those from non-AIDS patients and the environment, showed increased virulence. Simi...

journal_title：Microbial pathogenesis

authors： Reddy VM,Parikh K,Luna-Herrera J,Falkinham JO 3rd,Brown S,Gangadharam PR

更新日期：1994-02-01 00:00:00

abstract：:Recognised as the leading cause of nosocomial antibiotic-associated diarrhoea, the incidence of Clostridium difficile infection (CDI) remains high despite efforts to improve prevention and reduce the spread of the bacterium in healthcare settings. In the last decade, many studies have focused on the epidemiology and r...

journal_title：Microbial pathogenesis

authors： Rodriguez C,Van Broeck J,Taminiau B,Delmée M,Daube G

更新日期：2016-08-01 00:00:00

abstract：:Diagnosis of toxoplasmosis is an important issue, especially in at-risk patients. The molecular methods showed a promising future for such diagnosis; however, the method itself and the target sequence to be detected is an important part of accurate detection of the infection. The aim of the present study was to evalua...

journal_title：Microbial pathogenesis

authors： Valian HK,Mirhendi H,Mohebali M,Shojaee S,Fallahi S,Jafari R,Kheirandish F,Mousavi P

更新日期：2020-03-01 00:00:00

abstract：:Pathogenic yersiniae undergo an established low calcium response (LCR) at 37 degrees C in Ca2+-deficient media characterized by restricted growth with synthesis of Lcr plasmid-encoded virulence functions. The latter include outer membrane peptides (Yops) known to undergo Pst plasmid-mediated post-translational degrada...

journal_title：Microbial pathogenesis

authors： Mehigh RJ,Sample AK,Brubaker RR

更新日期：1989-03-01 00:00:00

abstract：:The gene clusters encoding various P-fimbriae (F7(1), F7(2), F9 and F11) were compared. Deletion plasmids that lack the gene encoding the fimbrillin were derived from these gene clusters. Introduction of these deletion plasmids into an E. coli K12 strain resulted in non-fimbriated cells that still showed mannose-resis...

journal_title：Microbial pathogenesis

authors： van Die I,Zuidweg E,Hoekstra W,Bergmans H

更新日期：1986-02-01 00:00:00

abstract：:Three coagulase-negative Staphylococcus species (CNS) (Staphylococcus epidermidis, Staphylococcus xylosus and Staphylococcus hyicus), from the milk of cows with mastitis, were used to evaluate adherence to and internalization by bovine mammary epithelial cells, and to investigate involvement of host cell signal transd...

journal_title：Microbial pathogenesis

authors： Almeida RA,Oliver SP

更新日期：2001-11-01 00:00:00

abstract：:Resistance to antimicrobials is a challenging issue that complicates the treatment of infections caused by bacteria and fungi, thus requiring new therapeutic options. Oncocalyxone A, a benzoquinone obtained from Auxemma oncocalyx (Allem) Taub has several biological effects; however, there is no data on its antimicrobi...

journal_title：Microbial pathogenesis

authors： da Silva RE,Ribeiro FOS,de Carvalho AMA,Daboit TC,Marinho-Filho JDB,Matos TS,Pessoa ODL,de Souza de Almeida Leite JR,de Araújo AR,Dos Santos Soares MJ

更新日期：2020-12-01 00:00:00

abstract：:Thanks to the progress and decreasing costs in genome sequencing technologies, more than 250,000 bacterial genomes are currently available in public databases, covering most, if not all, of the major human-associated phylogenetic groups of these microorganisms, pathogenic or not. In addition, for many of them, sequenc...

journal_title：Microbial pathogenesis

authors： Anani H,Zgheib R,Hasni I,Raoult D,Fournier PE

更新日期：2020-12-01 00:00:00

abstract：:The emerging prevalence of multidrug-resistance in Gram-negative pathogens, due to conventional antimicrobial therapeutics, has led the researchers to emphasize on development of alternative novel strategies to suppress the bacterial virulence and pathogenicity through inhibition of quorum sensing (QS) and biofilms. Q...

journal_title：Microbial pathogenesis

authors： Qais FA,Khan MS,Ahmad I

更新日期：2019-01-01 00:00:00

abstract：:We aimed to identify key pathways to further explore the molecular mechanism underlying pediatric pneumonia using differential pathway network which integrated protein-protein interactions (PPI) data and pathway information. PPI data and pathway information were obtained from STRING and Reactome database, respectively...

journal_title：Microbial pathogenesis

authors： Yang JB,Luo R,Yan Y,Chen Y

更新日期：2016-12-01 00:00:00

abstract：:β-1,3-glucan plays a role in non-albicans Candida species biofilm formation and survival of biofilm Candida to stresses. In this study, we evaluated the antibiofilm activity of β-1,3-glucanase, which can degrade poly-β(1 → 3)-glucose of non-albicans Candida species biofilms, on single and mixed species biofilm of non-...

journal_title：Microbial pathogenesis

authors： Tan Y,Leonhard M,Ma S,Moser D,Schneider-Stickler B

更新日期：2017-12-01 00:00:00

abstract：:Mycobacterium tuberculosis (MTB) the causative organism of tuberculosis can remain dormant as a non-culturable organism, reactivate and cause disease in man and animals. There is a need for proof of viability of such organisms in order to understand the process of reactivation. PCR for bacterial DNA cannot distinguish...

journal_title：Microbial pathogenesis

authors： Pai SR,Actor JK,Sepulveda E,Hunter RL Jr,Jagannath C

更新日期：2000-06-01 00:00:00

abstract：:Recent studies have been considered to symbiotic interactions of the human gastrointestinal microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota continuously stimulates the immune system against opportunistic and pathogen bacteria from infancy. Changes in gastrointestinal microbiota ...

journal_title：Microbial pathogenesis

authors： Gholizadeh P,Mahallei M,Pormohammad A,Varshochi M,Ganbarov K,Zeinalzadeh E,Yousefi B,Bastami M,Tanomand A,Mahmood SS,Yousefi M,Asgharzadeh M,Kafil HS

更新日期：2019-02-01 00:00:00

abstract：:Quorum sensing (QS), a cell-to-cell communication mechanism present in many bacterial species plays a key role in regulating the virulence factor and biofilm formation in many pathogens, which causes severe public health risk. Therefore, interfering with QS mechanism offers an attractive strategy to combat bacterial i...

journal_title：Microbial pathogenesis

authors： Vasavi HS,Sudeep HV,Lingaraju HB,Shyam Prasad K

更新日期：2017-03-01 00:00:00

abstract：:Foot and Mouth disease (FMD) is economically devastating, highly contagious transboundry viral disease of livestock with 100% morbidity, rapid spread and severe production losses in animals. The FMDV has seven different serotypes. There is no vaccine that can protect animals from all serotypes. Hence, it is need of th...

journal_title：Microbial pathogenesis

authors： Raza S,Siddique K,Rabbani M,Yaqub T,Anjum AA,Ibrahim M,Azhar M,Jamil F,Rasheed MA

更新日期：2019-03-01 00:00:00

abstract：:Multidrug-resistant (MDR) pathogens are currently causing serious problems globally in the medical setting. Improper and extensive usage of antibiotics results in a selective pressure supporting the rise of antibiotic-resistant microbes. Many key cellular bacterial components, including enzymes and small noncoding RNA...

journal_title：Microbial pathogenesis

authors： Shin J,Prabhakaran VS,Kim KS

更新日期：2018-03-01 00:00:00

abstract：:The antimicrobial properties of morel compounds from wild edible mushrooms (Morchella esculenta and Verpa bohemica) from Kashmir valley was investigated against different clinical pathogens. The butanol crude fraction of most popular or true morel M. esculenta showed highest 19 mm IZD against E.coli while as same frac...

journal_title：Microbial pathogenesis

authors： Shameem N,Kamili AN,Ahmad M,Masoodi FA,Parray JA

更新日期：2017-04-01 00:00:00

abstract：:Carbohydrate analyses of whole-spore extracts have confirmed the presence of rhamnose in the spore of the fully virulent Ames strain of Bacillus anthracis. A gene cluster containing loci with high homology to the rhamnose biosynthetic genes, rmlACBD, was identified within the B. anthracis chromosome. The first gene of...

journal_title：Microbial pathogenesis

authors： Bozue JA,Parthasarathy N,Phillips LR,Cote CK,Fellows PF,Mendelson I,Shafferman A,Friedlander AM

更新日期：2005-01-01 00:00:00

abstract：:The search for new antimicrobial drugs has been necessary due to the increased bacterial resistance to antibiotics currently in use, and natural products play an important role in this field. The aim of this study was to evaluate the in vitro effect of cinnamaldehyde on S. epidermidis strains, biofilm set-up preventio...

journal_title：Microbial pathogenesis

authors： Albano M,Crulhas BP,Alves FCB,Pereira AFM,Andrade BFMT,Barbosa LN,Furlanetto A,Lyra LPDS,Rall VLM,Júnior AF

更新日期：2019-01-01 00:00:00

abstract：:NorA, NorB, and NorC are efflux proteins in the Nor family that regulate the secretion of fluoroquinolones, and MgrA/NorR is a transcription factor of the Nor family. Overexpression of Nor family proteins provides fluoroquinolone resistance in Staphylococcus aureus. However, in coagulase-negative staphylococci (CNS), ...

journal_title：Microbial pathogenesis

authors： Juárez-Verdayes MA,Parra-Ortega B,Hernández-Rodríguez C,Betanzos-Cabrera G,Rodríguez-Martínez S,Cancino-Diaz ME,Cancino-Diaz JC

更新日期：2012-06-01 00:00:00

abstract：:In this paper, we have assessed the role of changing physicochemical parameters and substrate types on the production of α-amylase enzyme from Penicillium chrysogenum, with a view to determining the optimal conditions required for its maximum production. The findings of this research revealed that, at pH 6 using linse...

journal_title：Microbial pathogenesis

authors： Dar GH,Kamili AN,Nazir R,Bandh SA,Jan TR,Chishti MZ

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Cronobacter spp. are Gram-negative, facultative-anaerobic, non-spore forming, enteric coliform bacteria, which belongs to the Enterobacteriaceae family. Cronobacter spp. are opportunistic pathogens that have brought rare but life-threatening infections such as meningitis, necrotizing enterocolitis and bloods...

journal_title：Microbial pathogenesis

authors： Holý O,Cruz-Córdova A,Xicohtencatl-Cortes J,Hochel I,Parra-Flores J,Petrželová J,Fačevicová K,Forsythe S,Alsonosi A

更新日期：2019-02-01 00:00:00

abstract：:Salmonella is an important cause of food-borne infection worldwide. Detection of outbreaks caused by Salmonella spp. relies on suitable and robust methods for genotyping. Little is known about the genetic diversity of the Salmonella enterica subspecies enterica serotype Infantis strains isolated from human sources in ...

journal_title：Microbial pathogenesis

authors： Ranjbar R,Ahmadi M,Memariani M

更新日期：2016-11-01 00:00:00

abstract：:The changes in the cell surface carbohydrates of the eustachian tube (ET) and middle ear subsequent to the intranasal (i.n.) inoculation of Streptococcus pneumoniae (Spn) type 6A were studied in the chinchilla model of otitis media (OM) using a lectin histochemical technique with six different lectins (SNA, WGA, Succ ...

journal_title：Microbial pathogenesis

authors： Linder TE,Daniels RL,Lim DJ,DeMaria TF

更新日期：1994-06-01 00:00:00

abstract：:We analyzed the complete genomic sequences of 17 porcine reproductive and respiratory syndrome virus (PRRSV) isolates from Southern China obtained between 2010 and 2011 and found that four of seven isolates from 2011 were closely related to the JXA1-R strain (vaccine virus of JXA1). This close relationship between fie...

journal_title：Microbial pathogenesis

authors： Zhang M,Xie J,Sun L,Cao Z,Gu H,Deng S,Chen Y,Cao Z,Tang F,Su S,Zhang G

更新日期：2013-12-01 00:00:00

abstract：:Synthesis of highly efficient antibacterial agents has become highly important due to emergence of antibiotic resistance. Herein, Pristine ZnO and ZnO-CuO nanocomposite has been synthesized by simple chemical co-precipitation method and characterized by X-ray diffraction (XRD), microscopic and spectroscopic techniques...

journal_title：Microbial pathogenesis

authors： Jan T,Azmat S,Mansoor Q,Waqas HM,Adil M,Ilyas SZ,Ahmad I,Ismail M

更新日期：2019-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is considered one of the most important causes of chronic liver diseases. Many reports have shown that the proteins of the HCV via interactions with gene expression regulatory networks such as cellular pathways and microRNAs can contribute to the development of chronic liver diseases....

journal_title：Microbial pathogenesis

authors： Khanizadeh S,Ravanshad M,Hosseini SY,Davoodian P,Almasian M,Khanlari Z

更新日期：2017-09-01 00:00:00

abstract：:As an economic devastating virus, porcine reproductive and respiratory syndrome virus (PRRSV) has spread globally, and seriously hinders the healthy development of the swine industry worldwide. In recent years, however, recombinant PRRSV strains are continuously emerging, resulting in the death of a large number of pi...

journal_title：Microbial pathogenesis

authors： Song Z,Zhang Q,Chen Y,Shen H,Yang G,Jiang P,Chen JL,Lin L

更新日期：2020-12-01 00:00:00