Abstract:
:Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus which is histopathologically characterized by inflammatory manifestations, indicating that rickettsiae induce mechanisms that amplify the inflammatory response. To understand the pathogenesis of scrub typhus, we examined chemokine and cytokine production after infection with O. tsutsugamushi in mice. The mRNAs that were upregulated included lymphotactin, RANTES (regulated upon activation, normal T-cell expressed and secreted), macrophage inflammatory proteins 1alpha/beta (MIP-1alpha/beta), MIP-2, monocyte chemoattractant protein 1, lymphotoxin beta, tumor necrosis factor alpha, interleukin-6, gamma-interferon, transforming growth factor beta1, and migration inhibition factor. Peak expression of these chemokines and cytokines was observed between 4 and 8 days after infection. Gene induction was followed by the secretion of chemokine and cytokine proteins. Chemokine profile in infected mice was well correlated with kinetics of inflammatory cell infiltration. Thus, O. tsutsugamushi appears to be a strong inducer of chemokines and cytokines which may, by the attraction and activation of phagocytic leukocytes, significantly contribute to inflammation observed in scrub typhus.
journal_name
Microb Pathogjournal_title
Microbial pathogenesisauthors
Koh YS,Yun JH,Seong SY,Choi MS,Kim ISdoi
10.1016/j.micpath.2003.08.006subject
Has Abstractpub_date
2004-01-01 00:00:00pages
51-7issue
1eissn
0882-4010issn
1096-1208pii
S0882401003001657journal_volume
36pub_type
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journal_title:Microbial pathogenesis
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doi:10.1006/mpat.1997.0146
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2010.04.003
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journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2003.09.003
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
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journal_title:Microbial pathogenesis
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Microbial pathogenesis
pub_type: 杂志文章,评审
doi:10.1016/j.micpath.2019.02.011
更新日期:2019-04-01 00:00:00
abstract:UNLABELLED:The outcome of Helicobacter pylori infection has been related to specific virulence-associated bacterial genotypes. The vacuolating cytotoxin (vacA), cagA gene, oipA and babA2 gene are important virulence factor involving gastric diseases. The objective of this study was to assess the relationship between vi...
journal_title:Microbial pathogenesis
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doi:10.1016/j.micpath.2015.01.008
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