当前位置： SCI文献检索 > MICROBIAL PATHOGENESIS期刊下所有文献 > A systematic review of Toxoplasma gondii antigens to find the best vaccine candidates for immunization.

A systematic review of Toxoplasma gondii antigens to find the best vaccine candidates for immunization.

Abstract：

:At present, there is not any available accepted vaccine for prevention of Toxoplasma gondii (T. gondii) in human and animals. We conducted literature search through English (Google Scholar, PubMed, Science Direct, Scopus, EBSCO, ISI Web of Science) scientific paper databases to find the best vaccine candidates against toxoplasmosis among T. gondii antigens. Articles with information on infective stage, pathogenicity, immunogenicity and characterization of antigens were selected. We considered that the ideal and significant vaccines should include different antigens and been expressed in all infective stages of the parasite with a high pathogenicity and immunogenicity. Evaluation within this systematic review indicates that MIC 3, 4, 13, ROP 2, RON 5, GRA 1, 6, 8, 14 are expressed in all three infective stages and have pathogenicity and immunogenicity. MIC 5, ROM 4, GRA 2, 4, 15, ROP 5, 16, 17, 38, RON 4, MIC 1, GRA 10, 12, 16, SAG 3 are expressed in only tachyzoites and bradyzoites stages of T. gondii with pathogenicity/immunogenicity. Some antigens appeared to be expressed in a single stage (tachyzoites) but have high pathogenicity and induce immune response. They include enolase2 (ENO2), SAG 1, SAG5D, HSP 70, ROM 1, ROM 5, AMA 1, ROP 18, RON2 and GRA 24. In conclusion, current vaccination against T. gondii infection is not satisfactory, and with the increasing number of high-risk individuals, the development of an effective and safe specific vaccine is greatly valuable for toxoplasmosis prevention. This systematic review reveals prepare candidates for immunization studies.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Rezaei F,Sarvi S,Sharif M,Hejazi SH,Pagheh AS,Aghayan SA,Daryani A

doi

10.1016/j.micpath.2018.11.003

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

172-184

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(18)31491-8

journal_volume

126

pub_type

杂志文章

相关文献

MICROBIAL PATHOGENESIS文献大全
  • Evidence for clathrin mobilization during directed phagocytosis of Shigella flexneri by HEp2 cells.

    abstract：:The enteroinvasive species Shigella flexneri expresses a plasmid-mediated capacity to penetrate epithelial cells by directed phagocytosis involving actin polymerization. In the present work, HEp2 cells were depleted of intracellular K+ in order to arrest receptor-mediated endocytosis and to evaluate the role of this e...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(89)90036-3

    authors： Clerc PL,Sansonetti PJ

    更新日期：1989-11-01 00:00:00

  • Expression of the Escherichia coli lamB gene in Vibrio cholerae.

    abstract：:A phage lambda mediated transduction system was devised to facilitate molecular analysis of Vibrio cholerae. A lamB expression plasmid, pAMH62 was introduced into Vibrio cholerae by conjugation. The resulting V. cholerae derivatives harboring pAMH62 produced substantial amounts of the LamB protein. This protein was pr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(86)90053-7

    authors： Harkki A,Hirst TR,Holmgren J,Palva ET

    更新日期：1986-06-01 00:00:00

  • Induction of innate immune response following introduction of infectious bronchitis virus (IBV) in the trachea and renal tissues of chickens.

    abstract：:Infectious bronchitis (IB) is a highly contagious respiratory disease of chickens, which is caused by the infectious bronchitis virus (IBV). The innate immune response is crucial for antiviral infections and revealing the pathogenic mechanisms of IBV. In this study, we presents an evaluation of interferon (I, II and I...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.01.008

    authors： Yang X,Li J,Liu H,Zhang P,Chen D,Men S,Li X,Wang H

    更新日期：2018-03-01 00:00:00

  • Alveolar microbiota profile in patients with human pulmonary tuberculosis and interstitial pneumonia.

    abstract：BACKGROUND:The presence of the human lung microbiota has been demonstrated in patients with different lung diseases, mainly in sputum samples. However, for study of the alveolar microbiota, a bronchoalveolar lavage (BAL) sample represents the lower respiratory tract (LRT) environment. It is currently unknown whether th...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103851

    authors： Vázquez-Pérez JA,Carrillo CO,Iñiguez-García MA,Romero-Espinoza I,Márquez-García JE,Falcón LI,Torres M,Herrera MT

    更新日期：2020-02-01 00:00:00

  • Location of adhesion sites for P-fimbriated and for 075X-positive Escherichia coli in the human kidney.

    abstract：:High-affinity binding sites for P-fimbriated and for 075X-positive Escherichia coli were located in the human kidney. Frozen sections of normal human kidney were double-stained first with fluorochrome-labelled bacteria and then with fluorochrome-labelled nephron site-specific lectins or antibodies. The P-fimbriate rec...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(86)90019-7

    authors： Nowicki B,Holthöfer H,Saraneva T,Rhen M,Väisänen-Rhen V,Korhonen TK

    更新日期：1986-04-01 00:00:00

  • Intracellular translocation and localization of Edwardsiella tarda type III secretion system effector EseG in host cells.

    abstract：:Edwardsiella tarda, an important fish pathogenic bacterium, could utilize type III secretion system (T3SS) to transfer multiple effector proteins into host cells during infection. EseG was identified to be an E. tarda T3SS effector, which could be injected by T3SS into non-phagocytic cells. Since E. tarda is a faculta...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.05.008

    authors： Fang S,Zhang L,Lou Y,Yang D,Wang Q,Zhang Y,Liu Q

    更新日期：2016-08-01 00:00:00

  • Glycobiology of the oral pathogen Porphyromonas gingivalis and related species.

    abstract：:Until recently, glycoproteins had only been described in eukaryotes. However, advances in detection methods and genome analyses have allowed the discovery of N-linked or O-linked glycoproteins, similar to those found in eukaryotes, in some bacterial species. These prokaryotic glycoproteins play roles in adhesion, solu...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2015.09.012

    authors： Shoji M,Nakayama K

    更新日期：2016-05-01 00:00:00

  • Looking in apes as a source of human pathogens.

    abstract：:Because of the close genetic relatedness between apes and humans, apes are susceptible to many human infectious agents and can serve as carriers of these pathogens. Consequently, they present a serious health hazard to humans. Moreover, many emerging infectious diseases originate in wildlife and continue to threaten h...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2014.09.003

    authors： Keita MB,Hamad I,Bittar F

    更新日期：2014-12-01 00:00:00

  • Development of inflammation and augmented chemotactic responsiveness of murine peritoneal macrophages following treatment with Entamoeba histolytica trophozoites.

    abstract：:The accumulation of inflammatory cells in the peritoneal cavity of C57BL/6 mice was examined following intraperitoneal injection of Entamoeba histolytica trophozoites. Two different strains of E. histolytica were used: a virulent strain (IP:0682:1) and a non-virulent strain (DKB). Injection of 10(6) trophozoites of ei...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(87)90097-0

    authors： Ghadirian E,Stevenson MM

    更新日期：1987-09-01 00:00:00

  • Nutritional interference for phenotypic biofilm quantification in Aeromonas spp. isolates containing the fla gene.

    abstract：:The Aeromonas genus has several virulence factors associated with the development of diseases in aquatic organisms, leading to losses in aquaculture. One of these factors is the flagella's formation which allows the biofilm's formation that provides the microorganisms a greater pathogenicity, greater protection to cer...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2018.11.044

    authors： Freire NB,Magalhães TC,Nunes Soares RA,da Costa MM,Gouveia GV

    更新日期：2019-02-01 00:00:00

  • Transcriptional analysis reveals the relativity of acid tolerance and antimicrobial peptide resistance of Salmonella.

    abstract：:The objective of this study was to comprehensively identify the target genes induced by acid stimulation in Salmonella, and to clarify the relativity of acid tolerance and antimicrobial peptide resistance. A clinical S. Typhimurium strain, S6, was selected and performed a transcriptome analysis under the acid toleranc...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.103701

    authors： Cao L,Wang J,Sun L,Kong Z,Wu Q,Wang Z

    更新日期：2019-11-01 00:00:00

  • DNA from virulent M. tuberculosis induces TNF-α production and autophagy in M1 polarized macrophages.

    abstract：:The macrophage innate immune response is outlined through recognition of the components of Mycobacterium tuberculosis. DNA of M. tuberculosis (MtbDNA) is recognized by macrophages, but the implications of this recognition are poorly characterized. Stimulation of murine macrophages with MtbDNA induces autophagy, a proc...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2019.04.041

    authors： Ruiz A,Guzmán-Beltrán S,Carreto-Binaghi LE,Gonzalez Y,Juárez E

    更新日期：2019-07-01 00:00:00

  • Rational selection of broadly cross-reactive family 2 PspA molecules for inclusion in chimeric pneumococcal vaccines.

    abstract：:Pneumococcal surface protein A (PspA) is a widely studied pneumococcal protein, exposed at the surface of all strains. It is an important virulence factor, preventing complement deposition as well as inhibiting the lytic effects of lactoferrin over pneumococci. Several studies have investigated the use of PspA as a ca...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.06.004

    authors： Converso TR,Goulart C,Rodriguez D,Darrieux M,Leite LCC

    更新日期：2017-08-01 00:00:00

  • Motility, biofilm formation, apoptotic effect and virulence gene expression of atypical Salmonella Typhimurium outside and inside Caco-2 cells.

    abstract：:Disease outbreaks related to waterborne pathogen contamination throughout the world as well as challenges that lie ahead for addressing persistent infection are of renewed interest. In this research, we studied the effects of prolonged exposure of Salmonella enterica serovar Typhimurium to the cues encountered in the ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.11.010

    authors： Chakroun I,Mahdhi A,Morcillo P,Cordero H,Cuesta A,Bakhrouf A,Mahdouani K,Esteban MÁ

    更新日期：2018-01-01 00:00:00

  • Aloe vera (Aloe barbadensis Miller) supplemented probiotic lassi prevents Shigella infiltration from epithelial barrier into systemic blood flow in mice model.

    abstract：:The aim of present work was to investigate preventive role of orally administered Aloe vera supplemented probiotic lassi (APL) on Shigella dysenteriae infection in mice. At the end of experimental period (2, 5 and 7 days of challenging), different organs such as spleen, liver, small intestine, large intestine, and per...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.11.023

    authors： Hussain SA,Patil GR,Reddi S,Yadav V,Pothuraju R,Singh RRB,Kapila S

    更新日期：2017-01-01 00:00:00

  • Cloning and molecular analysis of the Isi1 (rfaF) gene of Neisseria meningitidis which encodes a heptosyl-2-transferase involved in LPS biosynthesis: evaluation of surface exposed carbohydrates in LPS mediated toxicity for human endothelial cells.

    abstract：:Neisseria meningitidis, but not Haemophilus influenzae, damage cultured human endothelial cells. We have undertaken a study to generate genetically and structurally defined lipopolysaccharide (LPS) mutant strains of meningococci for functional studies to assess the role of surface exposed oligosaccharides in imparting...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.1995.0074

    authors： Jennings MP,Bisercic M,Dunn KL,Virji M,Martin A,Wilks KE,Richards JC,Moxon ER

    更新日期：1995-12-01 00:00:00

  • Differential expression of ompA, ompB, pyk, nlpD and Cpn0585 genes between normal and interferon-gamma treated cultures of Chlamydia pneumoniae.

    abstract：:A common feature of many chlamydial infections is that they are often asymptomatic and may persist for long periods of time if left untreated. In addition to the well recognized lytic stage of the chlamydial developmental cycle, evidence is now emerging to support a persistent phase in the cycle in which the reticulat...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1006/mpat.2000.0435

    authors： Mathews S,George C,Flegg C,Stenzel D,Timms P

    更新日期：2001-06-01 00:00:00

  • Phytochemical analysis and antibacterial activities extracts of mangrove leaf against the growth of some pathogenic bacteria.

    abstract：:In this study, the effects of water, ethanol, methanol and glycerin at five levels (0, 31.25, 83.33, 125 and 250 ml) were investigated on the efficiency of mangrove leaf extraction using mixture optimal design. The antimicrobial effect of the extracts on Streptococcus pneumoniae, Enterococcus faecium and Klebsiella pn...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.12.004

    authors： Alizadeh Behbahani B,Tabatabaei Yazdi F,Shahidi F,Noorbakhsh H,Vasiee A,Alghooneh A

    更新日期：2018-01-01 00:00:00

  • A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes.

    abstract：:Attenuated recombinant Listeria monocytogenes (Lm) strains are a promising class of vaccine vectors that trigger protective antigen-specific CD8 T cells. Listeriolysin O (LLO) is an important Lm virulence determinant allowing the bacterium to escape from the endocytic vacuole into the cell cytoplasm in phagocytic cell...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2007.08.002

    authors： Orgun NN,Way SS

    更新日期：2008-02-01 00:00:00

  • Genetic analysis of the plasmid region controlling virulence in Yersinia enterocolitica 0:9 by Mini-Mu insertions and lac gene fusions.

    abstract：:Enteropathogenic strains of Yersinia enterocolitica harbor a virulence plasmid (pYVe plasmid) of 70 kilobases (kb) which specifies, at 37 degrees C, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of outer membrane proteins (OMP). Some m...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(86)90067-7

    authors： Cornelis G,Sory MP,Laroche Y,Derclaye I

    更新日期：1986-08-01 00:00:00

  • Transcript analysis of nrrF, a Fur repressed sRNA of Neisseria gonorrhoeae.

    abstract：:Like most microorganisms, Neisseria gonorrhoeae alters gene expression in response to iron availability. The ferric uptake regulator Fur has been shown to be involved in controlling this response, but the extent of this involvement remains unknown. It is known that in addition to working directly to repress gene expre...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2008.12.003

    authors： Ducey TF,Jackson L,Orvis J,Dyer DW

    更新日期：2009-03-01 00:00:00

  • The 95ΔG mutation in the 5'untranslated region of the norA gene increases efflux activity in Staphylococcus epidermidis isolates.

    abstract：:In the Staphylococcus aureus ATCC25923 strain, the flqB mutation in the 5'untranslated region (5'UTR) of the norA gene causes increased norA mRNA expression and high efflux activity (HEA). The involvement of the norA gene 5'UTR in HEA has not been explored in S. epidermidis; therefore, we examined the function of this...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.12.021

    authors： García-Gómez E,Jaso-Vera ME,Juárez-Verdayes MA,Alcántar-Curiel MD,Zenteno JC,Betanzos-Cabrera G,Peralta H,Rodríguez-Martínez S,Cancino-Díaz ME,Jan-Roblero J,Cancino-Diaz JC

    更新日期：2017-02-01 00:00:00

  • Systematic expression profiling analysis mines dys-regulated modules in active tuberculosis based on re-weighted protein-protein interaction network and attract algorithm.

    abstract：:About 90% of tuberculosis (TB) patients latently infected with Mycobacterium tuberculosis (Mtb) show no symptoms, yet have a 10% chance in lifetime to progress active TB. Nevertheless, current diagnosis approaches need improvement in efficiency and sensitivity. The objective of this work was to detect potential signat...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.03.013

    authors： Sun Y,Weng Y,Zhang Y,Yan X,Guo L,Wang J,Song X,Yuan Y,Chang FY,Wang CL

    更新日期：2017-06-01 00:00:00

  • Differences in the carriage and the ability to utilize the serotype associated virulence plasmid in strains of Salmonella enterica serotype Typhimurium investigated by use of a self-transferable virulence plasmid, pOG669.

    abstract：:Most strains of Salmonella enterica subspecies enterica serotype typhimurium (S. typhimurium) naturally harbour a virulence plasmid which carries the salmonella plasmid virulence (spv) genes. However, isolates belonging to certain phage types are generally found without the plasmid. We have utilized a self-transferabl...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2004.02.005

    authors： Olsen JE,Brown DJ,Thomsen LE,Platt DJ,Chadfield MS

    更新日期：2004-06-01 00:00:00

  • Antibacterial mechanisms of cinnamon and its constituents: A review.

    abstract：BACKGROUND:In the current healthcare environment, an alarming rise in multi-drug resistant bacterial infections has led to a global health threat. The lack of new antibiotics has created a need for developing alternative strategies. OBJECTIVE:Understanding the antibacterial mechanisms of cinnamon and its constituents ...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2018.04.036

    authors： Vasconcelos NG,Croda J,Simionatto S

    更新日期：2018-07-01 00:00:00

  • Assessment of antigenic supplementation of bovine purified protein derivative for diagnosis of subclinical infection with Mycobacterium bovis in cattle.

    abstract：:Bovine tuberculosis (bTB) is usually diagnosed in vivo and ex vivo on the basis of delayed hypersensitivity reactions with a complex pool of antigens named bovine tuberculin (PPDB). The IFN-γ release assay (IGRA) for bTB is a blood-based assay that improves detection of infected cattle at early stages that escape skin...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2017.05.012

    authors： Alvarez AH,Gutiérrez-Ortega A,Gómez-Entzin V,Pérez-Mayorga G,Naranjo-Bastién J,González-Martínez V,Milián-Suazo F,Martínez-Velázquez M,Herrera-Rodríguez S,Hinojoza-Loza E

    更新日期：2017-07-01 00:00:00

  • The genus Aeromonas: A general approach.

    abstract：:The genus Aeromonas comprises more than thirty Gram-negative bacterial species which mostly act as opportunistic microorganisms. These bacteria are distributed naturally in diverse aquatic ecosystems, where they are easily isolated from animals such as fish and crustaceans. A capacity for adaptation also makes Aeromon...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章,评审

    doi：10.1016/j.micpath.2019.02.036

    authors： Gonçalves Pessoa RB,de Oliveira WF,Marques DSC,Dos Santos Correia MT,de Carvalho EVMM,Coelho LCBB

    更新日期：2019-05-01 00:00:00

  • Influence of experimental Anaplasma marginale infection and splenectomy on NTPDase and 5'nucleotidase activities in platelets of cattle.

    abstract：:The objective of this paper was to evaluate NTPDase and 5'-nucleotidase activities in platelets of bovine with and without spleen and infected by Anaplasma marginale. Our results demonstrate that infection along with splenectomy is able of inducing a profile of cellular protection, which showed an increase in the degr...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.02.019

    authors： Doyle RL,Oliveira CB,França RT,Doleski PH,Souza VC,Leal DBR,Martins JR,Lopes STA,Machado G,Da Silva AS,Andrade CM

    更新日期：2016-06-01 00:00:00

  • Increased monokines in cytomegalovirus infected myelomonocytic cell cultures.

    abstract：:In an investigation of the role of monokines in CMV associated immunosuppression we document modulation of both TNF and IL-1 beta in CMV infected THP-1 cells. CMV infected cultures released almost two-fold more IL-1 beta protein and contained significantly higher IL-1 beta mRNA levels than uninfected cultures for 72-9...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/0882-4010(89)90032-6

    authors： Turtinen LW,Assimacopoulos A,Haase AT

    更新日期：1989-08-01 00:00:00

  • Treponema denticola invasion into human gingival epithelial cells.

    abstract：:Host cell invasion is important for periodontal pathogens in evading host defenses and spreading into deeper areas of the periodontal tissue. Treponema denticola has been implicated in a number of potentially pathogenic processes, including periodontal tissue penetration. Here we tested the ability of T. denticola str...

    journal_title：Microbial pathogenesis

    pub_type： 杂志文章

    doi：10.1016/j.micpath.2016.01.010

    authors： Inagaki S,Kimizuka R,Kokubu E,Saito A,Ishihara K

    更新日期：2016-05-01 00:00:00